MSN 672 MODULE 4 EXAM 94 QUESTIONS WITH
VERIFIED ANSWERS 2025/2026
the D 2 antagonist actions predict efficacy for psychosis - CORRECT ANSWER When
D 2 blockers were approved for schizophrenia, it was not surprising that these
agents would work for psychotic symptoms associated with mania since what?
the recurrence of mania - CORRECT ANSWER it was somewhat surprising when
these dopamine/serotonin blockers proved effective for the core nonpsychotic
symptoms of mania and for maintenance treatment to prevent what?
MAO-B metabolizes serotonin (5HT) and norepinephrine (NE) only at high
concentrations - CORRECT ANSWER Selective inhibitors of MAO-B do not have
antidepressant efficacy. This is because of what?
MAO-A continues to destroy dopamine - CORRECT ANSWER Selective inhibition of
MAO-B has somewhat limited effects on dopamine concentrations because of
what?
Parkinson's disease - CORRECT ANSWER Inhibition of MAO-B does increase
dopamine to some extent which can be therapeutic in other disease states such as
what?
Dopamine - CORRECT ANSWER Combined inhibition of MAO-A and MAO-B may
have a robust antidepressant actions owing to increases not only in 5HT and
norepinephrine but what?
, D2 antagonism/partial agonism - CORRECT ANSWER Some of the
serotonin/dopamine antagonists/partial antagonists are effective for bipolar
depression likely due to what?
SSRIs/SNRIs when there is inadequate response - CORRECT ANSWER Some of the
serotonin/dopamine drugs have evidence of efficacy in unipolar depression as
augmenting what?
mixed features of mania - CORRECT ANSWER Some of the serotonin/dopamine
drugs have evidence of efficacy in unipolar and bipolar depression with what?
Antipsychotic effect in schizophrenia - CORRECT ANSWER Blocking the excessive
dopamine at D2 receptors should have as much of an antimanic effect in bipolar
as it does in what?
acute bipolar mania - CORRECT ANSWER Not all agents in the serotonin/dopamine
blocker class approved to treat schizophrenia are also approved to treat what?
bipolar maintenance - CORRECT ANSWER Not all agents in the
serotonin/dopamine blocker class approved to treat acute bipolar mania are also
approved to treat what?
lithium and valproate - CORRECT ANSWER To enhance antimanic response and to
[prevent relapse into another episode of mania, what agents are commonly used
in conjunction with dopamine serotonin blockers?
VERIFIED ANSWERS 2025/2026
the D 2 antagonist actions predict efficacy for psychosis - CORRECT ANSWER When
D 2 blockers were approved for schizophrenia, it was not surprising that these
agents would work for psychotic symptoms associated with mania since what?
the recurrence of mania - CORRECT ANSWER it was somewhat surprising when
these dopamine/serotonin blockers proved effective for the core nonpsychotic
symptoms of mania and for maintenance treatment to prevent what?
MAO-B metabolizes serotonin (5HT) and norepinephrine (NE) only at high
concentrations - CORRECT ANSWER Selective inhibitors of MAO-B do not have
antidepressant efficacy. This is because of what?
MAO-A continues to destroy dopamine - CORRECT ANSWER Selective inhibition of
MAO-B has somewhat limited effects on dopamine concentrations because of
what?
Parkinson's disease - CORRECT ANSWER Inhibition of MAO-B does increase
dopamine to some extent which can be therapeutic in other disease states such as
what?
Dopamine - CORRECT ANSWER Combined inhibition of MAO-A and MAO-B may
have a robust antidepressant actions owing to increases not only in 5HT and
norepinephrine but what?
, D2 antagonism/partial agonism - CORRECT ANSWER Some of the
serotonin/dopamine antagonists/partial antagonists are effective for bipolar
depression likely due to what?
SSRIs/SNRIs when there is inadequate response - CORRECT ANSWER Some of the
serotonin/dopamine drugs have evidence of efficacy in unipolar depression as
augmenting what?
mixed features of mania - CORRECT ANSWER Some of the serotonin/dopamine
drugs have evidence of efficacy in unipolar and bipolar depression with what?
Antipsychotic effect in schizophrenia - CORRECT ANSWER Blocking the excessive
dopamine at D2 receptors should have as much of an antimanic effect in bipolar
as it does in what?
acute bipolar mania - CORRECT ANSWER Not all agents in the serotonin/dopamine
blocker class approved to treat schizophrenia are also approved to treat what?
bipolar maintenance - CORRECT ANSWER Not all agents in the
serotonin/dopamine blocker class approved to treat acute bipolar mania are also
approved to treat what?
lithium and valproate - CORRECT ANSWER To enhance antimanic response and to
[prevent relapse into another episode of mania, what agents are commonly used
in conjunction with dopamine serotonin blockers?
