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Pharmacology HESI NR-293 | 100 Exam Questions | Pain Meds, GI Drugs, Endocrine, Cardio | Chamberlain University

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This document offers 100 HESI-style pharmacology exam questions and answers, created as a focused practice tool for students enrolled in NR-293 Pharmacology for Nursing Practice at Chamberlain University. It closely aligns with the HESI Pharmacology Specialty Exam structure, testing clinical decision-making, patient safety, and evidence-based nursing interventions. The practice questions span a wide range of high-yield topics, including opioid administration and titration, glucocorticoids, cardiac medications (ACE inhibitors, digoxin, beta-blockers), gastrointestinal drugs (PPIs, antacids, H2 blockers), antibiotics (cephalosporins, tetracycline, aminoglycosides), and endocrine pharmacology (insulin types, thyroid implications, diabetes meds). Critical nursing actions are also tested, such as assessing for adverse effects, recognizing drug interactions, and managing medications with narrow therapeutic indices. Each question is paired with the correct answer and rationale to deepen understanding. The material in this document is compatible with the widely used textbook: Pharmacology: A Patient-Centered Nursing Process Approach by Kee, Hayes, and McCuistion, making it an excellent companion for lecture, review, or pre-exam reinforcement. Who should use this resource: Pre-licensure ADN or BSN nursing students RN-to-BSN bridge students preparing for pharmacology exams Students in NCLEX-RN prep programs focusing on medication safety Learners in LPN/LVN to RN transitions Any student preparing for the HESI Pharmacology Specialty Exam This document is structured to improve both recall and critical thinking—ideal for timed practice and mastery of exam-level pharmacology. Keywords: hesi pharmacology 2026, nr-293, pharmacology practice questions, opioids nursing, gi drugs, cardiac meds, insulin therapy, nursing pharmacology, hesi practice test, chamberlain university, nclex pharmacology, endocrine drugs, medication interactions

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Pharmacology Hesi Practice 2
2026 Exam Questions and
Answers | A+ Score Assured


A client receives a prescription for esomeprazole (Nexium) for heartburn.

Which finding in the client's history should the nurse report to the

healthcare provider before administering the prescription?




Eats spicy food three times a week.

History of deep vein thrombosis.

Drinks 2 alcoholic beverages on weekends.

,Family history of diabetes mellitus. - 🧠 ANSWER ✔✔History of deep vein

thrombosis.

A male client who is in the terminal stage of cancer is cared for at home by

his family and receives a prescription for morphine at a rate to control

intractable pain. When the hospice nurse visits, the client awakens, moans

in severe pain, and asks for an increase in the morphine dosage. After

determining the client's respirations are 10 per minute, what is the best

action for the nurse to implement?




Titrate the morphine dose upward until the client has adequate pain relief.

Suggest to the family that they can also give the client ibuprofen, a non-

narcotic analgesic.

Hold additional morphine until the client's respirations are at least 16 per

minute.

Inform the client that an increased dose of morphine increases side effects

without additional pain control. - 🧠 ANSWER ✔✔Titrate the morphine dose

upward until the client has adequate pain relief.

,A client with Paget's disease is started on calcitonin (Calcimar) 500 mcg

subcutaneously daily. During the initial treatment, what is the priority

nursing action?




Assess the injection site for inflammation.

Evaluate the client's level of pain.

Monitor the client's alkaline phosphatase levels.


Observe the client for signs of hypersensitivity. - 🧠 ANSWER ✔✔Observe

the client for signs of hypersensitivity.

A client is taking cyclosporine for renal allograft rejection prevention. After 9

months of drug therapy, the nurse reviews laboratory data and notes that

the blood urea nitrogen level is 36 mg/dl. What additional finding should the

nurse identify?




Hypotension.

White blood cell count 10,000.

Creatinine 28 mg/dl.



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, Anaphylactic reaction. - 🧠 ANSWER ✔✔Creatinine 28 mg/dl.


The nurse receives a unit of blood from the blood bank for a postoperative

client who is currently in the X-ray department. What action should the

nurse implement?




Return the blood to the blood bank for refrigeration within 30 minutes.

Hang the blood transfusion as soon as the client returns to the unit.

Store the blood bag in the nursing unit's refrigerator until the client returns.

Take the unit of blood to the X-ray department to initiate the transfusion. - 🧠

ANSWER ✔✔Return the blood to the blood bank for refrigeration within 30

minutes.

Which side effects should the nurse monitor for a client who is receiving

dexamethasone (Decadron) following neurosurgery? (Select all that apply.)




Select all that apply

Mood swings.

Decreased appetite.

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