Neuro Pharmacology- Exam 4 With
Correct Answers
What is the goal of spasticity management? - Ans--Improve gait and ability
to perform ADLs
What are two scales to measure spasticity? - Ans--Ashworth or Tardieu
What is a scale to measure spasms? - Ans--Penn scale
Must be cautious when using medications to resolve excessive muscle tone
because spasticity may mask underlying ___________ and spasticity may
be required for the patient to remain __________. - Ans--Weakness;
Upright
Spasticity management medications are well-studied in multiple sclerosis
(MS), spinal cord injury (SCI) and stroke, but what two pathologies have
less data/research? - Ans--Traumatic brain injury (TBI) and cerebral palsy
(CP)
Usefulness is limited by ________ __________, so start with a low dose,
slowly increase, and use lowest possible effective dose. - Ans--Adverse
effects
This medication binds and activates GABA receptors and is indicated for
spasticity associated with MS, SCI, SP and stroke. - Ans--Diazepam
(Valium)
A patient presents to your clinic with a PMH of MS. She reports drowsiness,
fatigue, ataxia, and getting ill acutely when forgetting to take her medication
(indicative of physical dependency). What anti-spasticity agent is your
patient most likely taking? - Ans--Diazepam (Valium)
, This anti-spasticity medication inhibits calcium influx causing interference
with the excitation-contraction coupling process, thus resulting in skeletal
muscle relaxation. It is useful in patients with stroke, CP, SCI and MS. -
Ans--Dantrolene (Dantrium)
This anti-spasticity medication takes about 4-7 days to see a response and
is contraindicated in patients who require spasticity for balance, walking
and posture. - Ans--Dantrolene (Dantrium)
Dantrolene (Dantrium) has minimal cognitive adverse effects, diarrhea, and
the usually transient ADEs of drowsiness dizziness, weakness, malaise
and fatigue. However, rarely what more serious ADEs are sometimes
associated with this medication? Thus should be avoided in what patient
population? - Ans--Hepatotoxiicty, cardiac or respiratory failure. Avoid in
patients with severe underlying disease of liver, lungs or heart.
Dantrolene may be combined with diazepam, but should be discontinued if
what occur? - Ans--Increased spasticity
This drug's MOA includes binding and activating GABA receptors? - Ans--
Diazepam (Valium)
This drug's MOA includes inhibiting calcium influx, thus interfering with
excitation-contraction coupling process resulting in skeletal muscle
relaxation? - Ans--Dantrolene (Dantrium)
This drug's MOA binds toe GABA(b) receptors which is similar to another
drug that treats spasticity? - Ans--Oral Baclofen (Lioresal)
Your 46 year-old patient just abruptly stopped taking this medication for
spasticity and presents complaining of hallucinations, fever and just had a
recent seizure. What medication was your patient taking? - Ans--Oral
baclofen (Lioresal)
This method of dosing anti-spasticity medication is indicated for spinal cord
spasticity patients who are unresponsive to or with intolerable adverse
effects with oral treatment? - Ans--Intrathecal baclofen pump
Correct Answers
What is the goal of spasticity management? - Ans--Improve gait and ability
to perform ADLs
What are two scales to measure spasticity? - Ans--Ashworth or Tardieu
What is a scale to measure spasms? - Ans--Penn scale
Must be cautious when using medications to resolve excessive muscle tone
because spasticity may mask underlying ___________ and spasticity may
be required for the patient to remain __________. - Ans--Weakness;
Upright
Spasticity management medications are well-studied in multiple sclerosis
(MS), spinal cord injury (SCI) and stroke, but what two pathologies have
less data/research? - Ans--Traumatic brain injury (TBI) and cerebral palsy
(CP)
Usefulness is limited by ________ __________, so start with a low dose,
slowly increase, and use lowest possible effective dose. - Ans--Adverse
effects
This medication binds and activates GABA receptors and is indicated for
spasticity associated with MS, SCI, SP and stroke. - Ans--Diazepam
(Valium)
A patient presents to your clinic with a PMH of MS. She reports drowsiness,
fatigue, ataxia, and getting ill acutely when forgetting to take her medication
(indicative of physical dependency). What anti-spasticity agent is your
patient most likely taking? - Ans--Diazepam (Valium)
, This anti-spasticity medication inhibits calcium influx causing interference
with the excitation-contraction coupling process, thus resulting in skeletal
muscle relaxation. It is useful in patients with stroke, CP, SCI and MS. -
Ans--Dantrolene (Dantrium)
This anti-spasticity medication takes about 4-7 days to see a response and
is contraindicated in patients who require spasticity for balance, walking
and posture. - Ans--Dantrolene (Dantrium)
Dantrolene (Dantrium) has minimal cognitive adverse effects, diarrhea, and
the usually transient ADEs of drowsiness dizziness, weakness, malaise
and fatigue. However, rarely what more serious ADEs are sometimes
associated with this medication? Thus should be avoided in what patient
population? - Ans--Hepatotoxiicty, cardiac or respiratory failure. Avoid in
patients with severe underlying disease of liver, lungs or heart.
Dantrolene may be combined with diazepam, but should be discontinued if
what occur? - Ans--Increased spasticity
This drug's MOA includes binding and activating GABA receptors? - Ans--
Diazepam (Valium)
This drug's MOA includes inhibiting calcium influx, thus interfering with
excitation-contraction coupling process resulting in skeletal muscle
relaxation? - Ans--Dantrolene (Dantrium)
This drug's MOA binds toe GABA(b) receptors which is similar to another
drug that treats spasticity? - Ans--Oral Baclofen (Lioresal)
Your 46 year-old patient just abruptly stopped taking this medication for
spasticity and presents complaining of hallucinations, fever and just had a
recent seizure. What medication was your patient taking? - Ans--Oral
baclofen (Lioresal)
This method of dosing anti-spasticity medication is indicated for spinal cord
spasticity patients who are unresponsive to or with intolerable adverse
effects with oral treatment? - Ans--Intrathecal baclofen pump
