PHM 350 Exam 3 Drugs Questions With
Correct Answers
Cyclophosphamide |(Cytoxan) |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Must |be |metabolized |by |liver
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Mechlorethamine |(Mustargen) |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Shortest |duration |(metabolized |quickly)
Only |used |IV
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
,Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Chlorambucil |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Least |Toxic
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Least |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Carmutine |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Lipid |Soluble |- |Cross |BBB |for |brain |tumor
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
,Renal |Toxicity
Lomustine |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Lipid |Soluble |- |Cross |BBB |for |brain |tumor
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Cisplatin |- |CORRECT |ANSWER✔✔-Cross |Links |DNA
Similar |to |Alkylating |Agent
Inhibit |DNA |Synthesis
Inhibit |Protein |Synthesis
Renal |toxicity |limits |the |dose. |Need |to |stay |hydrated
Mitomycin |- |CORRECT |ANSWER✔✔-Antibiotic |Used |for |Chemotherapy
Alkylates |DNA
6-Mercaptopurine |- |CORRECT |ANSWER✔✔-Antimetabolite |- |Purine |(Adenine) |Analog
Produce |abnormal |DNA
, Failure |of |cell |replication
Failure |of |Protein |production
cell |death
Targets |rapidly |dividing |cells |(GI, |skin |and |bone |marrow |issues)
Nausea
Hair |Loss
Bone |Marrow |suppression
Thioguanine |- |CORRECT |ANSWER✔✔-Antimetabolite |- |Purine |(Guanine) |Analog
Produce |abnormal |DNA
Failure |of |cell |replication
Failure |of |Protein |production
cell |death
Used |as |immunosuppressant |in |crohns
Targets |rapidly |dividing |cells |(GI, |skin |and |bone |marrow |issues)
Nausea
Hair |Loss
Bone |Marrow |suppression
5-Fluorouracil |- |CORRECT |ANSWER✔✔-Antimetabolite |- |Pyrimidine |(Uracil) |Analog
Substitutes |for |uracil |which |is |the |precursor |to |Thymidine
Doesn't |work |and |thymidine |isn't |produced
Correct Answers
Cyclophosphamide |(Cytoxan) |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Must |be |metabolized |by |liver
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Mechlorethamine |(Mustargen) |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Shortest |duration |(metabolized |quickly)
Only |used |IV
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
,Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Chlorambucil |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Least |Toxic
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Least |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Carmutine |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Lipid |Soluble |- |Cross |BBB |for |brain |tumor
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
,Renal |Toxicity
Lomustine |- |CORRECT |ANSWER✔✔-DNA |Alkylating |Agent
Lipid |Soluble |- |Cross |BBB |for |brain |tumor
Inhibits |DNA |replication
Slows |cell |replication |and |reduces |protein |production
Very |Toxic
Nausea
Hair |Loss
Bone |Marrows |suppression
Renal |Toxicity
Cisplatin |- |CORRECT |ANSWER✔✔-Cross |Links |DNA
Similar |to |Alkylating |Agent
Inhibit |DNA |Synthesis
Inhibit |Protein |Synthesis
Renal |toxicity |limits |the |dose. |Need |to |stay |hydrated
Mitomycin |- |CORRECT |ANSWER✔✔-Antibiotic |Used |for |Chemotherapy
Alkylates |DNA
6-Mercaptopurine |- |CORRECT |ANSWER✔✔-Antimetabolite |- |Purine |(Adenine) |Analog
Produce |abnormal |DNA
, Failure |of |cell |replication
Failure |of |Protein |production
cell |death
Targets |rapidly |dividing |cells |(GI, |skin |and |bone |marrow |issues)
Nausea
Hair |Loss
Bone |Marrow |suppression
Thioguanine |- |CORRECT |ANSWER✔✔-Antimetabolite |- |Purine |(Guanine) |Analog
Produce |abnormal |DNA
Failure |of |cell |replication
Failure |of |Protein |production
cell |death
Used |as |immunosuppressant |in |crohns
Targets |rapidly |dividing |cells |(GI, |skin |and |bone |marrow |issues)
Nausea
Hair |Loss
Bone |Marrow |suppression
5-Fluorouracil |- |CORRECT |ANSWER✔✔-Antimetabolite |- |Pyrimidine |(Uracil) |Analog
Substitutes |for |uracil |which |is |the |precursor |to |Thymidine
Doesn't |work |and |thymidine |isn't |produced
