PHM 350 Exam 2 Questions With Correct
Answers
AS |a |non-steroidal |anti-inflammatory |drug, |aspirin:
A |- |inhibits |actions |of |both |cyclooxygenase |& |lipoxygenase
B |- |increases |phagocytic |macrophage |migration |into |tissue |at |sites |of |inflammation
C |- |used |to |treat |headache |& |fever
D |- |used |as |prophylactic |medication |to |prevent |development |of |arthritis
E |- |none |of |the |above |- |CORRECT |ANSWER✔✔-C |- |used |to |treat |headache |& |fever
As |a |non-steroidal |anti-inflammatory |drug, |aspirin:
A |- |increases |activity |& |effects |cyclooxygenase |but |not |of |lipoxygenase
B |- |decreases |phagocytic |macrophage |migration |into |tissue |at |sites |of |inflammation
C |- |used |to |treat |headache |& |fever |because |it |doesn't |cause |irritation |of |the |GI |tract
D |- |used |to |prevent |osteoporosis
E |- |A |& |C |- |CORRECT |ANSWER✔✔-B |- |decreases |phagocytic |macrophage |migration |into |tissue |
at |sites |of |inflammation
Glucocorticoids |such |as |predisnone |(DELTASONE):
A |- |induce |hyperglycemia
B |- |useful |to |treat |Type |II |diabetes
C |- |used |to |treat |conditions |characterized |by |chronic |inflammation
D |- |treat |Type |I |diabetes |because |these |drugs |induce |insulin |release |from |pancreas
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
,Which |of |the |following |statements |about |anti-inflammatory |drugs |is |correct?
A |- |one |of |the |more |frequent |adverse |side |effects |of |indomethacin |(INDOCIN) |is |metabolic |
acidosis
B |- |one |of |the |more |frequent |adverse |side |effects |of |aspirin |is |bone |marrow |suppressant
C |- |one |of |the |more |frequent |adverse |side |effects |of |prednisone |(DELTASONE) |is |development |
of |osteoporosis
D |- |one |of |the |more |frequent |adverse |side |effects |of |low |dose |aspirin |is |suppression |of |blood |
clotting |processes
E- |A |& |C |- |CORRECT |ANSWER✔✔-C |- |one |of |the |more |frequent |adverse |side |effects |of |
prednisone |(DELTASONE) |is |development |of |osteoporosis
Which |of |the |following |drugs |causes |hepatotoxicity |in |overdose?
A |- |Celecoxib |(CELEBREX)
B |- |Prednisone |(DELTASONE)
C |- |Acetaminophen |(TYLENON)
D |- |Ibuprofen |(MOTRIN)
E |- |A |& |C |- |CORRECT |ANSWER✔✔-C |- |Acetaminophen |(TYLENON)
The |advantage |of |using |celecoxib |(CELEBREX) |for |treatment |of |arthritis |pain |(compared |to |use |
of |aspirin) |is |that:
A |- |Celecoxib |produces |GI |irritation |at |lower |incidence |than |aspirin |does
B |- |Celecoxib |is |a |lipoxygenase |inhibitor |& |aspirin |isn't
C |- |Celecoxib |inhibits |COX-2 |but |not |COX-1 |but |aspirin |only |inhibits |COX-1
D |- |Celecoxib |increases |blood |flow |to |inflamed |joints
E |- |A |& |C |- |CORRECT |ANSWER✔✔-A |- |Celecoxib |produces |GI |irritation |at |lower |incidence |than |
aspirin |does
,Indomethacin |(INDOCIN) |is |used |to |treat:
A |- |gout
B |- |infertility
C |- |rheumatoid |arthritis
D |- |congestive |heart |failure
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
Acetaminophen |(TYLENOL):
A |- |like |aspirin |is |a |useful |anti-pyretic |drug |BECAUSE |it |inhibits |central |cyclooxygenases
B |- |blocks |pain |pathways |in |CNS
C |- |is |a |weak |anti-inflammatory |drug |BECAUSE |it's |bound/inhibited |by |peroxide |compounds |
formed |at |sites |of |inflammation
D |- |alters |cellular |respiration |& |upsets |blood |acid-base |balance
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
COX |Inhibitors:
A |- |interfere |with |neuronal |opiate |receptor |pain |pathways
B |- |are |anti-inflammatory |drugs |BECAUSE |they |reduce |leukotriene |production
C |- |cause |altered |metabolism |of |carbohydrate, |fat |& |protein
D |- |reduce |pain |sensitivity |at |sties |throughout |the |body |(not |just |at |sites |of |inflammation)
E |- |none |of |the |above |- |CORRECT |ANSWER✔✔-E |- |none |of |the |above
A |drug |which |has |anti-inflammatory |effects |BECAUSE |it |increases |lipocortin |in |so |called
|"inflammatory |cells:"
A |- |Prednisone |(DELTASONIE)
B |- |Montelukast |(SINGULAIR)
C |- |Aspirin
, D |- |Zileuton |(ZYFLO)
E |- |A |& |C |- |CORRECT |ANSWER✔✔-A |- |Prednisone |(DELTASONIE)
Dexamethaxone |(MAXIDEX) |is |used |to |treat:
A |- |headache
B |- |rheumatoid |arthritis
C |- |hypertension
D |- |arrhythmias |resulting |from |inappropriate |ventricular |automaticity
E |- |A |& |C |- |CORRECT |ANSWER✔✔-B |- |rheumatoid |arthritis
Steroid |hormone |receptors:
A |- |are |cytosolic |(i.e. |located |in |cytoplasm)
B |- |are |embedded |in |plasma |membrane
C |- |when |activated, |alter |protein |synthesis
D |- |mediate |responses |which |terminate |rapidly |when |steroid |agonist |concentration |is |
decreased
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
Which |of |the |following |anti-inflammatory |drugs |is |used |therapeutically |to |decrease |formation |
of |blood |clots:
A |- |ibuprofen |(MOTRIN, |ADVIL)
B |- |acetaminophen |(TYLENOL)
C |- |montelukast |(SINGULAIR)
D |- |zileuton |(ZYFLO)
E |- |aspirin |- |CORRECT |ANSWER✔✔-E |- |aspirin
As |an |anti-inflammatory |agent, |prednisone |(DELTASONE):
Answers
AS |a |non-steroidal |anti-inflammatory |drug, |aspirin:
A |- |inhibits |actions |of |both |cyclooxygenase |& |lipoxygenase
B |- |increases |phagocytic |macrophage |migration |into |tissue |at |sites |of |inflammation
C |- |used |to |treat |headache |& |fever
D |- |used |as |prophylactic |medication |to |prevent |development |of |arthritis
E |- |none |of |the |above |- |CORRECT |ANSWER✔✔-C |- |used |to |treat |headache |& |fever
As |a |non-steroidal |anti-inflammatory |drug, |aspirin:
A |- |increases |activity |& |effects |cyclooxygenase |but |not |of |lipoxygenase
B |- |decreases |phagocytic |macrophage |migration |into |tissue |at |sites |of |inflammation
C |- |used |to |treat |headache |& |fever |because |it |doesn't |cause |irritation |of |the |GI |tract
D |- |used |to |prevent |osteoporosis
E |- |A |& |C |- |CORRECT |ANSWER✔✔-B |- |decreases |phagocytic |macrophage |migration |into |tissue |
at |sites |of |inflammation
Glucocorticoids |such |as |predisnone |(DELTASONE):
A |- |induce |hyperglycemia
B |- |useful |to |treat |Type |II |diabetes
C |- |used |to |treat |conditions |characterized |by |chronic |inflammation
D |- |treat |Type |I |diabetes |because |these |drugs |induce |insulin |release |from |pancreas
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
,Which |of |the |following |statements |about |anti-inflammatory |drugs |is |correct?
A |- |one |of |the |more |frequent |adverse |side |effects |of |indomethacin |(INDOCIN) |is |metabolic |
acidosis
B |- |one |of |the |more |frequent |adverse |side |effects |of |aspirin |is |bone |marrow |suppressant
C |- |one |of |the |more |frequent |adverse |side |effects |of |prednisone |(DELTASONE) |is |development |
of |osteoporosis
D |- |one |of |the |more |frequent |adverse |side |effects |of |low |dose |aspirin |is |suppression |of |blood |
clotting |processes
E- |A |& |C |- |CORRECT |ANSWER✔✔-C |- |one |of |the |more |frequent |adverse |side |effects |of |
prednisone |(DELTASONE) |is |development |of |osteoporosis
Which |of |the |following |drugs |causes |hepatotoxicity |in |overdose?
A |- |Celecoxib |(CELEBREX)
B |- |Prednisone |(DELTASONE)
C |- |Acetaminophen |(TYLENON)
D |- |Ibuprofen |(MOTRIN)
E |- |A |& |C |- |CORRECT |ANSWER✔✔-C |- |Acetaminophen |(TYLENON)
The |advantage |of |using |celecoxib |(CELEBREX) |for |treatment |of |arthritis |pain |(compared |to |use |
of |aspirin) |is |that:
A |- |Celecoxib |produces |GI |irritation |at |lower |incidence |than |aspirin |does
B |- |Celecoxib |is |a |lipoxygenase |inhibitor |& |aspirin |isn't
C |- |Celecoxib |inhibits |COX-2 |but |not |COX-1 |but |aspirin |only |inhibits |COX-1
D |- |Celecoxib |increases |blood |flow |to |inflamed |joints
E |- |A |& |C |- |CORRECT |ANSWER✔✔-A |- |Celecoxib |produces |GI |irritation |at |lower |incidence |than |
aspirin |does
,Indomethacin |(INDOCIN) |is |used |to |treat:
A |- |gout
B |- |infertility
C |- |rheumatoid |arthritis
D |- |congestive |heart |failure
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
Acetaminophen |(TYLENOL):
A |- |like |aspirin |is |a |useful |anti-pyretic |drug |BECAUSE |it |inhibits |central |cyclooxygenases
B |- |blocks |pain |pathways |in |CNS
C |- |is |a |weak |anti-inflammatory |drug |BECAUSE |it's |bound/inhibited |by |peroxide |compounds |
formed |at |sites |of |inflammation
D |- |alters |cellular |respiration |& |upsets |blood |acid-base |balance
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
COX |Inhibitors:
A |- |interfere |with |neuronal |opiate |receptor |pain |pathways
B |- |are |anti-inflammatory |drugs |BECAUSE |they |reduce |leukotriene |production
C |- |cause |altered |metabolism |of |carbohydrate, |fat |& |protein
D |- |reduce |pain |sensitivity |at |sties |throughout |the |body |(not |just |at |sites |of |inflammation)
E |- |none |of |the |above |- |CORRECT |ANSWER✔✔-E |- |none |of |the |above
A |drug |which |has |anti-inflammatory |effects |BECAUSE |it |increases |lipocortin |in |so |called
|"inflammatory |cells:"
A |- |Prednisone |(DELTASONIE)
B |- |Montelukast |(SINGULAIR)
C |- |Aspirin
, D |- |Zileuton |(ZYFLO)
E |- |A |& |C |- |CORRECT |ANSWER✔✔-A |- |Prednisone |(DELTASONIE)
Dexamethaxone |(MAXIDEX) |is |used |to |treat:
A |- |headache
B |- |rheumatoid |arthritis
C |- |hypertension
D |- |arrhythmias |resulting |from |inappropriate |ventricular |automaticity
E |- |A |& |C |- |CORRECT |ANSWER✔✔-B |- |rheumatoid |arthritis
Steroid |hormone |receptors:
A |- |are |cytosolic |(i.e. |located |in |cytoplasm)
B |- |are |embedded |in |plasma |membrane
C |- |when |activated, |alter |protein |synthesis
D |- |mediate |responses |which |terminate |rapidly |when |steroid |agonist |concentration |is |
decreased
E |- |A |& |C |- |CORRECT |ANSWER✔✔-E |- |A |& |C
Which |of |the |following |anti-inflammatory |drugs |is |used |therapeutically |to |decrease |formation |
of |blood |clots:
A |- |ibuprofen |(MOTRIN, |ADVIL)
B |- |acetaminophen |(TYLENOL)
C |- |montelukast |(SINGULAIR)
D |- |zileuton |(ZYFLO)
E |- |aspirin |- |CORRECT |ANSWER✔✔-E |- |aspirin
As |an |anti-inflammatory |agent, |prednisone |(DELTASONE):
