PHM 350 FINAL EXAM QUESTIONS WITH CORRECT ANSWERS

PHM 350 FINAL EXAM QUESTIONS WITH
CORRECT ANSWERS

Cyclophosphamide |(CYTOXAN) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

* |Nitrogen |Mustard



- |alkylates |DNA

- |inhibits |DNA |replication

- |slows |cell |replication

- |reduces |protein |production

- |very |toxic



* |must |be |metabolically |activated |in |the |liver



Mechlorethamine |(MUSTARGEN) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

* |Nitrogen |Mustard



- |alkylates |DNA

- |inhibits |DNA |replication

- |slows |cell |replication

- |reduces |protein |production

- |very |toxic



* |shortest |duration |of |action |with |respect |to |potential |to |alkylate |DNA |(rapid |elimination)

* |only |used |by |IV |injection

,Chlorambucil |(LEUKERAN) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

* |Nitrogen |Mustard



- |alkylates |DNA

- |inhibits |DNA |replication

- |slows |cell |replication

- |reduces |protein |production

- |very |toxic



* |least |toxic |agent |of |"nitrogen |mustard" |group



Carmustine |(BCNU)

Lomustine |(CCNU) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

* |Nitrogen |Mustard



- |alkylates |DNA

- |inhibits |DNA |replication

- |slows |cell |replication

- |reduces |protein |production

- |very |toxic



* |alkylate |RNA

* |lipid-soluble |--> |crosses |BBB |--> |effects |on |brain |tumors



Mitomycin |(MUTAMYCIN) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

,* |antibiotic |used |primarily |as |cancer |chemotherapy |drug



- |alkylates |DNA |(not |alkyl |donor)

- |causes |DNA |strand |breakage

- |inhibits |DNA |synthesis

- |inhibits |protein |synthesis

- |inhibits |cell |replication



Doxorubicin |(ADRIAMYCIN)

Idarubicin |(IDAMYCIN) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

* |Anthracyclines



- |do |not |technically |alkylate |DNA

- |crosslinks |DNA |strands

- |inhibits |DNA |replication

- |slows |cell |replication

- |reduces |protein |production



Cisplatin |(PLATINOL)

Carboplatin |(PARAPLATIN) |- |CORRECT |ANSWER✔✔-* |Alkylating |cancer |drug

* |Platins



- |do |not |technically |alkylate |DNA

- |bind |to |& |cross |links |DNA |strands

- |inhibits |DNA |synthesis

- |inhibits |protein |synthesis

, - |inhibits |cell |replication



* |Cisplatin |Major |SE: |renal |toxicity |(dose |limiting, |can |be |reduced |by |proper |hydration)



Uses |of |Alkylating |Agents |- |CORRECT |ANSWER✔✔-- |Hodgkin's |disease

- |lymphoma

- |leukemia

- |ovarian, |breast |& |testicular |cancer

- |head, |neck |& |lung |cancer

- |neuroblastomas

- |brain |tumors



Side |Effects |of |Alkylating |Agents |- |CORRECT |ANSWER✔✔-* |largely |result |of |inhibition |of |cell |
replication

- |nausea

- |hair |loss

- |bone |marrow |suppression

- |tiredness

- |increased |bleeding |time

- |increase |susceptibility |to |infection

- |renal |toxicity

- |hemorrhagic |cystitis



6-Mercaptopurine |(PURINETHOL, |6-MP)

Thioguanine |(TABLOID) |- |CORRECT |ANSWER✔✔-* |Antimetabolites

* |Purine |Analogs |- |"Purine |Antagonists"