PHM 431 EXAM QUESTIONS WITH
COMPLETE SOLUTIONS
Alcohol |is |a |drug |with |properties |that |differentiate |it |from |other |abused |drugs. |These |unique |
properties |include: |- |CORRECT |ANSWER✔✔-elimination |occurs |via |zero |order |kinetics
Genetic |variations |lead |to |increases |or |decreases |in |the |risk |for |drug |addiction. |A |loss |of |
function |mutation |(a |mutation |that |leads |to |decreased |enzyme |activity) |in |the |gene |that |
encodes |which |of |the |following |enzymes |would |lead |to |a |decreased |risk |for |alcohol |addiction |-
|CORRECT |ANSWER✔✔-aldehyde |dehydrogenase
Which |of |the |following |does |not |contribute |to |alcohol |induced |liver |cirrhosis?
A)
Leak |of |endotoxin |from |the |gastrointestinal |tract
B)
Increased |NADH/NAD+ |ratio
C)
CYP450 |generation |of |reactive |oxygen |species
D)
Inactivation |of |alcohol |dehydrogenase |- |CORRECT |ANSWER✔✔-D
You |are |using |the |novelty |suppressed |feeding |assay |(the |open |field |test) |to |test |new |drugs. |
You |are |studying |the |interaction |between |two |drugs |in |this |assay |and |the |results |are |shown |in
|the |figure |on |the |right. |Which |of |the |following |Drug1/Drug |2 |pairs |is |most |likely |to |explain |
these |results? |- |CORRECT |ANSWER✔✔-diazepame/picrotoxin
, A |laboratory |rat |is |tested |before |and |after |alprazolam |treatment |in |the |novelty |suppressed |
feeding |test |(open |field |test) |and |the |alprazolam |induced |change |in |feeding |latency |is |
recorded. |The |same |rat |is |then |treated |with |alcohol |for |1 |week |and |retested |with |alprazolam |
in |the |novelty |suppressed |feeding |test. |What |would |the |anticipated |results |(and |underlying |
mechanism) |be |during |the |alprazolam |retest? |- |CORRECT |ANSWER✔✔-an |increase |in |feeding |
latency |because |of |a |pharmacodynamic |cross |tolerance |between |ethanol |and |alprazolam
A |drug |which |blocks |which |of |the |following |receptors |would |likely |increase |anxiety |because |it |
would |inhibit |NPY |release |from |neurons |in |the |amygdala? |- |CORRECT |ANSWER✔✔-CRF |
receptors
The |brain |has |an |endogenous |anxiolytic |feedback |system |that |inhibits |the |neural |circuits |
responsible |for |anxiety. |The |molecular |pathway |responsible |for |this |anti-anxiety |effect |is: |- |
CORRECT |ANSWER✔✔-Corticotrophin |releasing |factor-adenylate |cyclase |protein |kinase |A-CREB
Which |of |the |following |drugs |would |likely |produce |cross |tolerance |with |alcohol?
A)
Clonazepam
B)
Flunitrazepam
C)
Alprazolam
D)
All |of |the |above |- |CORRECT |ANSWER✔✔-All |of |the |above
Alcohol |and |benzodiazepines |both |act |on |which |brain |area |to |reduce |anxiety |- |CORRECT |
ANSWER✔✔-amygdala
The |attached |figure |shows |the |results |of |an |open |field |drug |study. |The |Y |axis |shows |the |
latency |for |a |mice |to |move |from |the |edge |to |the |center |of |the |open |field |chamber. |The |data |
COMPLETE SOLUTIONS
Alcohol |is |a |drug |with |properties |that |differentiate |it |from |other |abused |drugs. |These |unique |
properties |include: |- |CORRECT |ANSWER✔✔-elimination |occurs |via |zero |order |kinetics
Genetic |variations |lead |to |increases |or |decreases |in |the |risk |for |drug |addiction. |A |loss |of |
function |mutation |(a |mutation |that |leads |to |decreased |enzyme |activity) |in |the |gene |that |
encodes |which |of |the |following |enzymes |would |lead |to |a |decreased |risk |for |alcohol |addiction |-
|CORRECT |ANSWER✔✔-aldehyde |dehydrogenase
Which |of |the |following |does |not |contribute |to |alcohol |induced |liver |cirrhosis?
A)
Leak |of |endotoxin |from |the |gastrointestinal |tract
B)
Increased |NADH/NAD+ |ratio
C)
CYP450 |generation |of |reactive |oxygen |species
D)
Inactivation |of |alcohol |dehydrogenase |- |CORRECT |ANSWER✔✔-D
You |are |using |the |novelty |suppressed |feeding |assay |(the |open |field |test) |to |test |new |drugs. |
You |are |studying |the |interaction |between |two |drugs |in |this |assay |and |the |results |are |shown |in
|the |figure |on |the |right. |Which |of |the |following |Drug1/Drug |2 |pairs |is |most |likely |to |explain |
these |results? |- |CORRECT |ANSWER✔✔-diazepame/picrotoxin
, A |laboratory |rat |is |tested |before |and |after |alprazolam |treatment |in |the |novelty |suppressed |
feeding |test |(open |field |test) |and |the |alprazolam |induced |change |in |feeding |latency |is |
recorded. |The |same |rat |is |then |treated |with |alcohol |for |1 |week |and |retested |with |alprazolam |
in |the |novelty |suppressed |feeding |test. |What |would |the |anticipated |results |(and |underlying |
mechanism) |be |during |the |alprazolam |retest? |- |CORRECT |ANSWER✔✔-an |increase |in |feeding |
latency |because |of |a |pharmacodynamic |cross |tolerance |between |ethanol |and |alprazolam
A |drug |which |blocks |which |of |the |following |receptors |would |likely |increase |anxiety |because |it |
would |inhibit |NPY |release |from |neurons |in |the |amygdala? |- |CORRECT |ANSWER✔✔-CRF |
receptors
The |brain |has |an |endogenous |anxiolytic |feedback |system |that |inhibits |the |neural |circuits |
responsible |for |anxiety. |The |molecular |pathway |responsible |for |this |anti-anxiety |effect |is: |- |
CORRECT |ANSWER✔✔-Corticotrophin |releasing |factor-adenylate |cyclase |protein |kinase |A-CREB
Which |of |the |following |drugs |would |likely |produce |cross |tolerance |with |alcohol?
A)
Clonazepam
B)
Flunitrazepam
C)
Alprazolam
D)
All |of |the |above |- |CORRECT |ANSWER✔✔-All |of |the |above
Alcohol |and |benzodiazepines |both |act |on |which |brain |area |to |reduce |anxiety |- |CORRECT |
ANSWER✔✔-amygdala
The |attached |figure |shows |the |results |of |an |open |field |drug |study. |The |Y |axis |shows |the |
latency |for |a |mice |to |move |from |the |edge |to |the |center |of |the |open |field |chamber. |The |data |
