PHM 431 Exam 2 Questions With Correct Answers

PHM 431 Exam 2 Questions With Correct
Answers

A |loss |of |function |mutation |in |the |gene |that |encodes |the |enzyme |glucuronyl |transferase |will |
likely |cause



A) |An |increase |in |the |risk |of |a |morphine |overdose |in |patients |having |the |mutation |if |they |were
|to |receive |morphine |for |pain |relief



B) |Accelerated |deacetylation |of |heroin |in |the |brain |leading |to |higher |morphine |concentrations |
and |an |increased |risk |for |overdose

C) |Less |efficient |alcohol |metabolism |and |higher |blood |alcohol |levels

D) |"Bioactivation" |of |heroin |to |morphine |and |increased |risk |for |morphine |overdose |- |CORRECT
|ANSWER✔✔-A) |An |increase |in |the |risk |of |a |morphine |overdose |in |patients |having |the |


mutation |if |they |were |to |receive |morphine |for |pain |relief



Genetic |variations |lead |to |increases |or |decreases |in |the |risk |for |drug |addiction. |A |loss |of |
function |mutation |(a |mutation |that |leads |to |decreased |enzyme |activitity) |in |the |gene |that |
encodes |which |of |the |following |enzymes |would |lead |to |a |decreased |risk |for |alcohol |
addicition?



A) |Alcohol |dehydrogenase

B) |CYP2E1

C) |Aldehyde |dehydrogenase

D) |Glucuronyl |transferase |- |CORRECT |ANSWER✔✔-C) |aldehyde |dehydrogenase



Smoking |marijuana |to |deliver |delta-9-THC |to |the |brain |is |more |efficient |than |orally |
administered |delta-9-THC |because:

,A) |Combustion |(smoking) |is |required |to |produce |delta-9-THC |from |cannabis |leaves

B) |No |first |pass |effect |after |smoking

C) |Delta-9-THC |is |degraded |in |the |acidic |environment |of |the |stomach

D) |Delta-9-THC |is |poorly |absorbed |from |the |small |intestine |- |CORRECT |ANSWER✔✔-B) |no |first
|pass |effect |after |smoking




Which |brain |region |is |important |for |morphine |induced |analgesia?



A) |amygdala

B) |prefrontal |cortex

C) |ventral |tegmental |area

D) |periaqueductal |gray |- |CORRECT |ANSWER✔✔-periaqueductal |gray



Increases |in |nerve |terminal |calcium |signals |which |be |associated |with |deletion |fo |which |of |the |
following |genes?



A) |Kappa |opiate |receptor |gene

B) |Alpha |subunit |of |the |GABAA |receptor

C) |Adenylate |cyclase |gene

D) |NMDA |receptor |gene |- |CORRECT |ANSWER✔✔-A) |kappa |opiate |receptor |gene



which |of |the |following |drugs |is |a |partial |agonist?



A) |morphine

B) |fentanyl

C) |methadone

, D) |meperidine |- |CORRECT |ANSWER✔✔-methadone



Alcohol |is |a |drug |with |properties |that |differentiate |it |from |other |abused |drugs. |These |unique |
properties |include:



A)Elimination |occurs |via |first |order |kinetics

B) |It |is |a |high |potency |drug

C) |Elimination |occurs |via |zero |order |kinetics

D) |Tolerance |develops |very |slowly |- |CORRECT |ANSWER✔✔-C) |elimination |occurs |via |zero |
order |kinetics



The |mechanism |by |which |endocannabinoids |suppress |neurotransmitter |release |involves:



A) |binding |to |CB1 |receptors |on |presynaptic |neurons

B) |binding |to |CB2 |receptors |on |presynaptic |neurons

C) |binding |to |CB2 |receptors |on |postsynaptic |neurons

D) |binding |to |CB2 |receptors |on |lymphocytes |- |CORRECT |ANSWER✔✔-A) |binding |to |CB1 |
receptors |on |presynaptic |neurons



Suboxone |is |a |newly |approved |drug |that |can |be |used |to |treat |morphine |or |heroin |addiction. |
Suboxone |is |useful |for |its' |intended |purpose |because |it |contains:




A) |methadone, |a |partial |opioid |receptor |agonist |that |is |orally |active |and |suppresses |
withdrawal |symptom

B) |fentanyl, |a |highly |potent |opioid |receptor |agonist |and |naltrexone, |an |opioid |receptor |
antagonist |that |is |orally |active