ROITT'S ESSENTIAL IMMUNOLOGY 12th
Edition (All MCQs With Answers)
Chapter 1
1 Which of the following does not protect body surfaces:
A Skin.
B Mucus.
C Gastric acid.
D Salivary amylase
E Gut microflora.
2 Pattern recognition receptors (PRR) include:
A LPS.
B PAMPs.
C Lipoteichoic acid.
D Lectin-like molecules.
E Unmethylated CpG sequences.
3 The mononuclear phagocyte system does not include:
A Monocytes.
B Kupffer cells.
C Kidney mesangial cells.
D Lymph node medullary macrophages.
E Endothelial cells.
4 A polymorphonuclear neutrophil (PMN):
A Is a bone marrow stem cell.
B Is closely similar to a mast cell.
C Contains microbicidal cytoplasmic granules.
D Is not a professional phagocytic cell.
E Has granules which stain with eosin.
,5 Which of the following is not produced following activation of the NADPH oxidase
microbicidal pathway
A O2 –
B O2
C H2O2
D NO
E OH
6 Neutrophil defensins are:
A Anti-toxins.
B Oxygen-dependent.
C Enzymes.
D Glycolipids.
E Peptide antibiotics.
7 The TLR9 pattern recognition receptor recognises:
A CpG motifs.
B Gram +ve peptidoglycan.
C Mycobacterial lipoarabinomannan.
D Gram –ve LPS.
E dsRNA.
8 Complement component C3 is cleaved by:
A C3b
B C3bBb
C Factor B
D Factor D
E Factor H
9 The membrane attack complex consists of:
A OH.
B Colicins
C C3b3b,Bb
D C5b,6,7,8,9
E Properdin
10 C3b:
, A Is chemotactic.
B Is an anaphylatoxin.
C Opsonizes bacteria.
D Directly injures bacteria.
E Is the inactive form of C3.
11 Acute inflammation characteristically involves:
A Constriction of arterioles.
B Capillary endothelial cell enlargement.
C Influx of macrophages.
D Influx of mast cells.
E Influx of neutrophils.
12 Lysozyme:
A Is a cytoplasmic organelle.
B Activates complement.
C Is a proteolytic enzyme.
D Splits peptidoglycan.
E Is released by mast cells.
13 Which of the following is not an acute phase protein:
A Serum amyloid P component.
B Chondroitin sulfate.
C C-reactive protein.
D Mannose binding lectin.
E Fibrinogen.
14 Interferons:
A Are found only in mammalian species.
B Are divided into 5 main families.
C Induce enzyme synthesis in the target cell.
D Only affect infected cells.
E Are specific for individual viruses.
15 Natural killer (NK) cells do not:
A Respond to interferon.
B Contain perforin.
, C Contain tumor necrosis factor (TNF).
D Kill only by damaging the target cell outer membrane.
E Contain serine proteases.
16 Eosinophils do not:
A Stain with basic dyes.
B Contain a major basic protein.
C Contain peroxidase.
D Give a respiratory burst on activation.
E Have C3b receptors.
17 Polymorphonuclear neutrophils attack bacteria:
A Exclusively by oxygen-dependent mechanisms.
B Exclusively by oxygen-independent mechanisms.
C By phagocytosis.
D By secreting complement.
E By secreting interferon.
18 A complement component which is strongly chemotactic for neutrophils is:
A C9
B C5a
C C3
D C3b
E C5b
19 Acute inflammation can be initiated by:
A Mast cell activation.
B Influx of neutrophils.
C An increase in vascular permeability.
D C3.
E Lysozyme.
Edition (All MCQs With Answers)
Chapter 1
1 Which of the following does not protect body surfaces:
A Skin.
B Mucus.
C Gastric acid.
D Salivary amylase
E Gut microflora.
2 Pattern recognition receptors (PRR) include:
A LPS.
B PAMPs.
C Lipoteichoic acid.
D Lectin-like molecules.
E Unmethylated CpG sequences.
3 The mononuclear phagocyte system does not include:
A Monocytes.
B Kupffer cells.
C Kidney mesangial cells.
D Lymph node medullary macrophages.
E Endothelial cells.
4 A polymorphonuclear neutrophil (PMN):
A Is a bone marrow stem cell.
B Is closely similar to a mast cell.
C Contains microbicidal cytoplasmic granules.
D Is not a professional phagocytic cell.
E Has granules which stain with eosin.
,5 Which of the following is not produced following activation of the NADPH oxidase
microbicidal pathway
A O2 –
B O2
C H2O2
D NO
E OH
6 Neutrophil defensins are:
A Anti-toxins.
B Oxygen-dependent.
C Enzymes.
D Glycolipids.
E Peptide antibiotics.
7 The TLR9 pattern recognition receptor recognises:
A CpG motifs.
B Gram +ve peptidoglycan.
C Mycobacterial lipoarabinomannan.
D Gram –ve LPS.
E dsRNA.
8 Complement component C3 is cleaved by:
A C3b
B C3bBb
C Factor B
D Factor D
E Factor H
9 The membrane attack complex consists of:
A OH.
B Colicins
C C3b3b,Bb
D C5b,6,7,8,9
E Properdin
10 C3b:
, A Is chemotactic.
B Is an anaphylatoxin.
C Opsonizes bacteria.
D Directly injures bacteria.
E Is the inactive form of C3.
11 Acute inflammation characteristically involves:
A Constriction of arterioles.
B Capillary endothelial cell enlargement.
C Influx of macrophages.
D Influx of mast cells.
E Influx of neutrophils.
12 Lysozyme:
A Is a cytoplasmic organelle.
B Activates complement.
C Is a proteolytic enzyme.
D Splits peptidoglycan.
E Is released by mast cells.
13 Which of the following is not an acute phase protein:
A Serum amyloid P component.
B Chondroitin sulfate.
C C-reactive protein.
D Mannose binding lectin.
E Fibrinogen.
14 Interferons:
A Are found only in mammalian species.
B Are divided into 5 main families.
C Induce enzyme synthesis in the target cell.
D Only affect infected cells.
E Are specific for individual viruses.
15 Natural killer (NK) cells do not:
A Respond to interferon.
B Contain perforin.
, C Contain tumor necrosis factor (TNF).
D Kill only by damaging the target cell outer membrane.
E Contain serine proteases.
16 Eosinophils do not:
A Stain with basic dyes.
B Contain a major basic protein.
C Contain peroxidase.
D Give a respiratory burst on activation.
E Have C3b receptors.
17 Polymorphonuclear neutrophils attack bacteria:
A Exclusively by oxygen-dependent mechanisms.
B Exclusively by oxygen-independent mechanisms.
C By phagocytosis.
D By secreting complement.
E By secreting interferon.
18 A complement component which is strongly chemotactic for neutrophils is:
A C9
B C5a
C C3
D C3b
E C5b
19 Acute inflammation can be initiated by:
A Mast cell activation.
B Influx of neutrophils.
C An increase in vascular permeability.
D C3.
E Lysozyme.
