L13 Parainfluenza Virus
What are paramyxoviruses?
Viruses causing respiratory infections in infants and young children
What are the important viruses that belong to Paramyxoviridae family?
- Respiratory Syncytial Virus
- Parainfluenza Virus
- Measles
- Mumps
- Nipah Virus
What are the most common reasons for the death of children?
- Acute respiratory infections and pneumonia
Describe the morphology of paramyxoviruses.
They resemble orthomyxoviruses, but they are larger and more pleomorphic.
They have a helical nucleocapsid, which contains a ss negative sense RNA
They are antigenically stable because they don’t undergo any genetic reassortment.
What do the structural proteins of paramyxoviruses form?
- Capsid
- Polymerase
- Matrix proteins
- Envelope glycoproteins
What is the envelope?
A host derived lipid envelope that contains coded glycoproteins (peplomers) and surrounds the
nucleocapsid.
Name the glycoproteins of paramyxoviruses:
- F-glycoproteins
Present in all paramyxoviruses and they mediate membrane fusion
They have hemolysin activity
- Larger glycoproteins
They help in the attachment to host cells
HN: have Hemagglutinin and Neuraminidase activity
H: only Hemagglutinin
G: Glycoproteins that help in attachment
What are paramyxoviruses?
Viruses causing respiratory infections in infants and young children
What are the important viruses that belong to Paramyxoviridae family?
- Respiratory Syncytial Virus
- Parainfluenza Virus
- Measles
- Mumps
- Nipah Virus
What are the most common reasons for the death of children?
- Acute respiratory infections and pneumonia
Describe the morphology of paramyxoviruses.
They resemble orthomyxoviruses, but they are larger and more pleomorphic.
They have a helical nucleocapsid, which contains a ss negative sense RNA
They are antigenically stable because they don’t undergo any genetic reassortment.
What do the structural proteins of paramyxoviruses form?
- Capsid
- Polymerase
- Matrix proteins
- Envelope glycoproteins
What is the envelope?
A host derived lipid envelope that contains coded glycoproteins (peplomers) and surrounds the
nucleocapsid.
Name the glycoproteins of paramyxoviruses:
- F-glycoproteins
Present in all paramyxoviruses and they mediate membrane fusion
They have hemolysin activity
- Larger glycoproteins
They help in the attachment to host cells
HN: have Hemagglutinin and Neuraminidase activity
H: only Hemagglutinin
G: Glycoproteins that help in attachment
