L11 Picornavirus
List enteroviruses serotypes
- Polio virus = 3
- Coxsackie virus A & B
A = 21 serotypes
B = 6 serotypes
- Echovirus = 34
- Parechovirus =2
What are the features of rhinoviruses?
They are transmitted by respiratory route, and they are known to cause common cold
They are spherical in shape and have icosahedral symmetry.
Capsid is composed of 60 subunits
ss +ive sense RNA
what is the incubation period of coxsackieviruses?
2-9 days
What are the clinical manifestations of coxsackieviruses?
- Aseptic meningitis: caused by all of B and A7 & A9
- Herpangina: febrile vesicular pharyngitis, caused by A2-6, A8, A10
viral infection of the mouth, characterized by ulcers at the back of the throat or the roof of
the mouth.
- Hand-Foot-Mouth disease: ulcers in the mouth, and rashes on hand and feet. Associated with
A16
- Pleurodynia: pain in the chest and abdomen, caused by group B
also known as Bornholm disease or epidemic myalgia
- Cardiac: myocarditis and pericarditis caused by B1-5
- Respiratory: groups A & B are usually associated with common cold.
pneumonia is caused by B4 & B5
- Acute hemorrhagic conjunctivitis: caused by A24 and enterovirus 70
It has a 1-day incubation period, and takes 8-10 days for complete recovery
- Generalized disease of infants: involves multiple organs, and is caused by group B viruses.
- Pancreatitis: leads to juvenile diabetes mellitus
caused by B1
How is coxsackie virus diagnosed?
Specimen collection
Virus isolation: intracerebral inoculation into suckling mice
List enteroviruses serotypes
- Polio virus = 3
- Coxsackie virus A & B
A = 21 serotypes
B = 6 serotypes
- Echovirus = 34
- Parechovirus =2
What are the features of rhinoviruses?
They are transmitted by respiratory route, and they are known to cause common cold
They are spherical in shape and have icosahedral symmetry.
Capsid is composed of 60 subunits
ss +ive sense RNA
what is the incubation period of coxsackieviruses?
2-9 days
What are the clinical manifestations of coxsackieviruses?
- Aseptic meningitis: caused by all of B and A7 & A9
- Herpangina: febrile vesicular pharyngitis, caused by A2-6, A8, A10
viral infection of the mouth, characterized by ulcers at the back of the throat or the roof of
the mouth.
- Hand-Foot-Mouth disease: ulcers in the mouth, and rashes on hand and feet. Associated with
A16
- Pleurodynia: pain in the chest and abdomen, caused by group B
also known as Bornholm disease or epidemic myalgia
- Cardiac: myocarditis and pericarditis caused by B1-5
- Respiratory: groups A & B are usually associated with common cold.
pneumonia is caused by B4 & B5
- Acute hemorrhagic conjunctivitis: caused by A24 and enterovirus 70
It has a 1-day incubation period, and takes 8-10 days for complete recovery
- Generalized disease of infants: involves multiple organs, and is caused by group B viruses.
- Pancreatitis: leads to juvenile diabetes mellitus
caused by B1
How is coxsackie virus diagnosed?
Specimen collection
Virus isolation: intracerebral inoculation into suckling mice
