GMS 6504 TEST PAPER 2026 EXAM QUESTIONS AND
ANSWERS SCORED A+
✔✔what amino acid most commonly serves as the gatekeeper residue in a kinase?
•threonine
•methionine
•lysine
•phenylalanine
•valine - ✔✔methionine
✔✔type 1 kinase inhibitors specifically target...
•serine/threonine kinases
•tyrosine kinases
•Bcr-AbI
•active kinases
•kinases with a valine as the gatekeeper residue - ✔✔active kinases
✔✔which would be expected to have the greatest selectivity towards the target
enzyme?
•ATP competitive kinase inhibitor
•allosteric kinase inhibitor - ✔✔allosteric kinase inhibitor
✔✔which resistance mechanism would reduce the apparent affinity of herceptin to the
HER2 receptor?
•epitope masking
•PTEN loss
•increased EGFR signaling
•reduced T cell activity - ✔✔epitope masking
✔✔where would you go to download the crystal structure of a protein you want to use
for molecular docking?
•PyMol
•chimera
•zinc
•cygwin
•PDB - ✔✔PDB
✔✔what is the purpose of the spheres that we made in the docking process?
•they represent the molecule that we're docking
, •they prevent a molecule from docking to wherever the spheres are located
•they tell the computer where we want molecules to dock to
•they represent water molecules that bind to the protein
•they define the electrostatic environment to use for energy calculations - ✔✔they tell
the computer where we want molecules to dock to
✔✔what is the purpose of the grid that we made in the docking process?
•they represent the molecule that we're docking
•they prevent a molecule from docking to wherever the spheres are located
•they tell the computer where we want molecules to dock to
•they represent water molecules that bind to the protein
•they define the electrostatic environment to use for energy calculations - ✔✔it defines
the electrostatic environment to use for energy calculations
✔✔would you expect to achieve more accurate docking using rigid ligands or flexible
ligands?
•rigid
•flexible - ✔✔flexible
✔✔how is a grid score calculated?
•it is the electrostatic score minus the van der waals score
•it is the van der waals score minus the electrostatic score
•it is the sum of the electrostatic score and the van der waals score - ✔✔it is the sum of
the electrostatic score and the van der waals score
✔✔which grid score would predict the best binding to a protein?
•-50
•-25
•0
•25
•50 - ✔✔-50
✔✔which type of immune cells are most directly responsible for the killing of cancer
cells during immunotherapy?
•antigen presenting cells
•cytotoxic T lymphocytes
•endothelial cells
•dendritic cells - ✔✔cytotoxic T lymphocytes
✔✔which type of antibody has a greater proportion of human sequence?
ANSWERS SCORED A+
✔✔what amino acid most commonly serves as the gatekeeper residue in a kinase?
•threonine
•methionine
•lysine
•phenylalanine
•valine - ✔✔methionine
✔✔type 1 kinase inhibitors specifically target...
•serine/threonine kinases
•tyrosine kinases
•Bcr-AbI
•active kinases
•kinases with a valine as the gatekeeper residue - ✔✔active kinases
✔✔which would be expected to have the greatest selectivity towards the target
enzyme?
•ATP competitive kinase inhibitor
•allosteric kinase inhibitor - ✔✔allosteric kinase inhibitor
✔✔which resistance mechanism would reduce the apparent affinity of herceptin to the
HER2 receptor?
•epitope masking
•PTEN loss
•increased EGFR signaling
•reduced T cell activity - ✔✔epitope masking
✔✔where would you go to download the crystal structure of a protein you want to use
for molecular docking?
•PyMol
•chimera
•zinc
•cygwin
•PDB - ✔✔PDB
✔✔what is the purpose of the spheres that we made in the docking process?
•they represent the molecule that we're docking
, •they prevent a molecule from docking to wherever the spheres are located
•they tell the computer where we want molecules to dock to
•they represent water molecules that bind to the protein
•they define the electrostatic environment to use for energy calculations - ✔✔they tell
the computer where we want molecules to dock to
✔✔what is the purpose of the grid that we made in the docking process?
•they represent the molecule that we're docking
•they prevent a molecule from docking to wherever the spheres are located
•they tell the computer where we want molecules to dock to
•they represent water molecules that bind to the protein
•they define the electrostatic environment to use for energy calculations - ✔✔it defines
the electrostatic environment to use for energy calculations
✔✔would you expect to achieve more accurate docking using rigid ligands or flexible
ligands?
•rigid
•flexible - ✔✔flexible
✔✔how is a grid score calculated?
•it is the electrostatic score minus the van der waals score
•it is the van der waals score minus the electrostatic score
•it is the sum of the electrostatic score and the van der waals score - ✔✔it is the sum of
the electrostatic score and the van der waals score
✔✔which grid score would predict the best binding to a protein?
•-50
•-25
•0
•25
•50 - ✔✔-50
✔✔which type of immune cells are most directly responsible for the killing of cancer
cells during immunotherapy?
•antigen presenting cells
•cytotoxic T lymphocytes
•endothelial cells
•dendritic cells - ✔✔cytotoxic T lymphocytes
✔✔which type of antibody has a greater proportion of human sequence?
