TEST BANK
GB
Cellular and Molecular Immunology
GB GB GB
Abul Abbas, Andrew Lichtman, and Shiv Pillai
GB GB GB GB GB GB
10th Edition
GB
,Table of Contents
GB GB
ChapterGB01GBPropertiesGBandGBOverviewGBofGBImmuneGBResponses 1
ChapterGB02GBCellsGBandGBTissuesGBofGBtheGBImmuneGBSystem 3
ChapterGB03GBLeukocyteGBCirculationGBandGBMigrationGBIntoGBTissues 6
ChapterGB04GBInnateGBImmunity 10
ChapterGB05GBAntibodiesGBandGBAntigens 17
ChapterGB06GBAntigenGBPresentationGBtoGBTGBLymphocytesGBandGBtheGBFunctionsGBofGBMajor
HistocompatibilityGBComplexGBMolecules 20
ChapterGB07GBImmuneGBReceptorsGBandGBSignalGBTransduction 27
ChapterGB08GBLymphocyteGBDevelopmentGBandGBAntigenGBReceptorGBGeneGBRearrangement 30
ChapterGB09GBActivationGBofGBTGBLymphocytes 34
ChapterGB10GBDifferentiationGBandGBFunctionsGBofGBCD4+GBEffectorGBTGBCells 38
ChapterGB11GBDifferentiationGBandGBFunctionsGBofGBCD8+GBEffectorGBTGBCells 42
ChapterGB12GBBGBCellGBActivationGBandGBAntibodyGBProduction 46
ChapterGB13GBEffectorGBMechanismsGBofGBHumoralGBImmunity 52
ChapterGB14GBSpecializedGBImmunityGBatGBEpithelialGBBarriersGBandGBinGBImmuneGBPrivilegedGBTissues 56
ChapterGB15GBImmunologicGBToleranceGBandGBAutoimmunity 62
ChapterGB16GBImmunityGBtoGBMicrobes 67
ChapterGB17GBTransplantationGBImmunology 72
ChapterGB18GBTumorGBImmunology 77
ChapterGB19GBHypersensitivityGBDisorders 81
ChapterGB20GBAllergy 86
ChapterGB21GBPrimaryGBandGBAcquiredGB Immunodeficiencies 89
,Chapter 01: Properties and Overview of Immune Responses
GB GB GB GB GB GB GB
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
GB GB GB GB GB GB GB GB GB
MULTIPLEGBCHOICE
1. TheGBprincipalGBfunctionGBofGBtheGBimmuneGBsystemGBis:
a. DefenseGBagainstGBcancer
b. RepairGBofGBinjuredGBtissues
c. DefenseGBagainstGBmicrobialGBinfections
d. PreventionGBofGBinflammatoryGBdiseases
e. ProtectionGBagainstGBenvironmentalGBtoxins
ANS:G B C
TheGBimmuneGBsystemGBhasGBevolvedGBinGBtheGBsettingGBofGBselectiveGBpressuresGBimposedGBbyGB
microbialGBinfections.GBAlthoughGBimmuneGBresponsesGBtoGBcancerGBmayGBoccur,GBtheGBconcept
GBthatGB“immunosurveillance”GBagainstGBcancerGBisGBaGBprincipalGBfunctionGBofGBtheGBimmuneGBs
ystemGBisGBcontroversial.GBRepairGBofGBinjuredGBtissuesGBmayGBbeGBaGBsecondaryGBconsequenceG
BofGBtheGBimmuneGBresponsesGBandGBinflammation.GBAlthoughGBtheGBimmuneGBsystemGBhasGBreg
ulatoryGBfeaturesGBthatGBareGBneededGBtoGBpreventGBexcessiveGBinflammation,GBpreventionGBofGBi
nflammatoryGBdiseasesGBisGBnotGBaGBprimaryGBfunction.GBTheGBimmuneGBsystemGBcanGBprotectGBa
gainstGBmicrobialGBtoxins,GBbutGBitGBgenerallyGBdoesGBnotGBofferGBprotectionGBagainstGBtoxinsGBof
GBnonbiologicGBorigin.
2. WhichGBofGBtheGBfollowingGBinfectiousGBdiseasesGBwasGBpreventedGBbyGBtheGBfirstGBsu
ccessfulGBvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:G B C
InGB1798,GBEdwardGBJennerGBreportedGBtheGBfirstGBintentionalGBsuccessfulGBvaccination,GBwhich
GBwasGBagainstGBsmallpoxGBinGBaGBboy,GBusingGBmaterialGBfromGBtheGBcowpoxGBpustulesGBofGBaGBmi
lkmaid.GBInGB1980,GBsmallpoxGBwasGBreportedGBtoGBbeGBeradicatedGBworldwideGBbyGBaGBvaccinat
ionGBprogram.GBEffectiveGBvaccinesGBagainstGBtetanusGBtoxin,GBrubellaGBvirus,GBandGBpoliovirusG
BwereGBdevelopedGBinGBtheGB20thGBcenturyGBandGBareGBwidelyGBused.GBThereGBisGBnoGBeffectiveGB
vaccineGBagainstGBMycobacteriumGBtuberculosis.
3. WhichGBofGBtheGBfollowingGBisGBaGBuniqueGBpropertyGBofGBtheGBadaptiveGBimmuneGBsystem?
a. HighlyGBdiverseGBrepertoireGBofGBspecificitiesGBforGBantigens
b. Self-nonselfGBdiscrimination
c. RecognitionGBofGBmicrobialGBstructuresGBbyGBbothGBcell-associatedGBandGBsolubleGBreceptors
d. ProtectionGBagainstGBviralGBinfections
e. ResponsesGBthatGBhaveGBtheGBsameGBkineticsGBandGBmagnitudeGBonGBrepeatedGBexposur
eGBtoGBtheGBsameGBmicrobe
ANS:G B A
, HighlyGBdiverseGBrepertoiresGBofGBspecificitiesGBforGBantigensGBareGBfoundGBonlyGBinGBTGBandGBB
GBlymphocytes,GBwhichGBareGBtheGBcentralGBcellularGBcomponentsGBofGBtheGBadaptiveGBimmuneGB
system.GBBothGBtheGBinnateGBandGBtheGBadaptiveGBimmuneGBsystemsGBuseGBcell-
associatedGBandGBsolubleGBreceptorsGBtoGBrecognizeGBmicrobes,GBdisplayGBsomeGBdegreeGBofGBsel
f-
nonselfGBdiscrimination,GBandGBprotectGBagainstGBviruses.GBOnGBrepeatedGBexposureGBtoGBtheGBsa
meGBmicrobe,GBtheGBadaptiveGBimmuneGBresponseGBbecomesGBmoreGBrapidGBandGBofGBgreaterGBm
agnitude;GBthisGBisGBtheGBmanifestationGBofGBmemory.
4. AntibodiesGBandGBTGBlymphocytesGBareGBtheGBrespectiveGBmediatorsGBofGBwhichGBtwoGB
typesGBofGBimmunity?
a. InnateGBandGBadaptive
b. PassiveGBandGBactive
c. SpecificGBandGBnonspecific
d. HumoralGBandGBcell-mediated
e. AdultGBandGBneonatal
ANS:G B D
BothGBBGBandGBTGBlymphocytesGBareGBprincipalGBcomponentsGBofGBadaptiveGBimmunity.GBBGBlym
phocytesGBproduceGBantibodies,GBwhichGBareGBtheGBrecognitionGBandGBeffectorGBmoleculesGBofGBh
umoralGBimmuneGBresponsesGBtoGBextracellularGBpathogens.GBTGBcellsGBrecognizeGBandGBpromote
GBeradicationGBofGBintracellularGBpathogensGBinGBcell-
mediatedGBimmunity.GBPassiveGBandGBactiveGBimmunityGBbothGBcanGBbeGBmediatedGBbyGBeitherGBBG
BorGBTGBlymphocytes.GBSpecificGBimmunityGBisGBanotherGBtermGBforGBadaptiveGBimmunity.GBBothGB
BGBandGBTGBlymphocytesGBparticipateGBinGBadultGBadaptiveGBimmunityGBbutGBareGBstillGBdevelopin
gGBinGBtheGBneonatalGBperiod.
5. TheGBtwoGBmajorGBfunctionalGBclassesGBofGBeffectorGBTGBlymphocytesGBare:
a. HelperGBTGBlymphocytesGBandGBcytotoxicGBTGBlymphocytes
b. NaturalGBkillerGBcellsGBandGBcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryGBTGBcellsGBandGBeffectorGBTGBcells
d. HelperGBcellsGBandGBantigen-presentingGBcells
e. CytotoxicGBTGBlymphocytesGBandGBtargetGBcells
ANS:G B A
TGBcellsGBcanGBbeGBclassifiedGBintoGBeffectorGBsubsetsGBthatGBperformGBdifferentGBeffectorGBfunctio
ns.GBMostGBeffectorGBTGBcellsGBareGBeitherGBhelperGBTGBlymphocytes,GBwhichGBenhanceGBtheGBres
ponsesGBofGBotherGBimmuneGBcells,GBincludingGBphagocytesGBandGBBGBcells,GBtoGBinfections,GBorG
BcytotoxicGBTGBlymphocytes,GBwhichGBdirectlyGBkillGBinfectedGBcells.GBNaturalGBkillerGBcellsGBare
GBnotGBTGBlymphocytes.
Antigen-
presentingGBcellsGBusuallyGBareGBnotGBTGBcells.GBMemoryGBTGBcellsGBareGBnotGBeffectorGBTGBcells.
6. WhichGBofGBtheGBfollowingGBcellGBtypesGBisGBrequiredGBforGBallGBadaptiveGBhumoralGBimmuneGBresponse
s?
a. NaturalGBkillerGBcells
b. DendriticGBcells
c. CytolyticGBTGBlymphocytes
d. BGBlymphocytes
e. HelperGBTGBlymphocytes
ANS:G B D
HumoralGBimmuneGBresponsesGBareGBantibody-
mediatedGBimmuneGBresponses,GBandGBallGBantibodiesGBareGBmadeGBbyGBBGBlymphocytesGBandG
GB
Cellular and Molecular Immunology
GB GB GB
Abul Abbas, Andrew Lichtman, and Shiv Pillai
GB GB GB GB GB GB
10th Edition
GB
,Table of Contents
GB GB
ChapterGB01GBPropertiesGBandGBOverviewGBofGBImmuneGBResponses 1
ChapterGB02GBCellsGBandGBTissuesGBofGBtheGBImmuneGBSystem 3
ChapterGB03GBLeukocyteGBCirculationGBandGBMigrationGBIntoGBTissues 6
ChapterGB04GBInnateGBImmunity 10
ChapterGB05GBAntibodiesGBandGBAntigens 17
ChapterGB06GBAntigenGBPresentationGBtoGBTGBLymphocytesGBandGBtheGBFunctionsGBofGBMajor
HistocompatibilityGBComplexGBMolecules 20
ChapterGB07GBImmuneGBReceptorsGBandGBSignalGBTransduction 27
ChapterGB08GBLymphocyteGBDevelopmentGBandGBAntigenGBReceptorGBGeneGBRearrangement 30
ChapterGB09GBActivationGBofGBTGBLymphocytes 34
ChapterGB10GBDifferentiationGBandGBFunctionsGBofGBCD4+GBEffectorGBTGBCells 38
ChapterGB11GBDifferentiationGBandGBFunctionsGBofGBCD8+GBEffectorGBTGBCells 42
ChapterGB12GBBGBCellGBActivationGBandGBAntibodyGBProduction 46
ChapterGB13GBEffectorGBMechanismsGBofGBHumoralGBImmunity 52
ChapterGB14GBSpecializedGBImmunityGBatGBEpithelialGBBarriersGBandGBinGBImmuneGBPrivilegedGBTissues 56
ChapterGB15GBImmunologicGBToleranceGBandGBAutoimmunity 62
ChapterGB16GBImmunityGBtoGBMicrobes 67
ChapterGB17GBTransplantationGBImmunology 72
ChapterGB18GBTumorGBImmunology 77
ChapterGB19GBHypersensitivityGBDisorders 81
ChapterGB20GBAllergy 86
ChapterGB21GBPrimaryGBandGBAcquiredGB Immunodeficiencies 89
,Chapter 01: Properties and Overview of Immune Responses
GB GB GB GB GB GB GB
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
GB GB GB GB GB GB GB GB GB
MULTIPLEGBCHOICE
1. TheGBprincipalGBfunctionGBofGBtheGBimmuneGBsystemGBis:
a. DefenseGBagainstGBcancer
b. RepairGBofGBinjuredGBtissues
c. DefenseGBagainstGBmicrobialGBinfections
d. PreventionGBofGBinflammatoryGBdiseases
e. ProtectionGBagainstGBenvironmentalGBtoxins
ANS:G B C
TheGBimmuneGBsystemGBhasGBevolvedGBinGBtheGBsettingGBofGBselectiveGBpressuresGBimposedGBbyGB
microbialGBinfections.GBAlthoughGBimmuneGBresponsesGBtoGBcancerGBmayGBoccur,GBtheGBconcept
GBthatGB“immunosurveillance”GBagainstGBcancerGBisGBaGBprincipalGBfunctionGBofGBtheGBimmuneGBs
ystemGBisGBcontroversial.GBRepairGBofGBinjuredGBtissuesGBmayGBbeGBaGBsecondaryGBconsequenceG
BofGBtheGBimmuneGBresponsesGBandGBinflammation.GBAlthoughGBtheGBimmuneGBsystemGBhasGBreg
ulatoryGBfeaturesGBthatGBareGBneededGBtoGBpreventGBexcessiveGBinflammation,GBpreventionGBofGBi
nflammatoryGBdiseasesGBisGBnotGBaGBprimaryGBfunction.GBTheGBimmuneGBsystemGBcanGBprotectGBa
gainstGBmicrobialGBtoxins,GBbutGBitGBgenerallyGBdoesGBnotGBofferGBprotectionGBagainstGBtoxinsGBof
GBnonbiologicGBorigin.
2. WhichGBofGBtheGBfollowingGBinfectiousGBdiseasesGBwasGBpreventedGBbyGBtheGBfirstGBsu
ccessfulGBvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:G B C
InGB1798,GBEdwardGBJennerGBreportedGBtheGBfirstGBintentionalGBsuccessfulGBvaccination,GBwhich
GBwasGBagainstGBsmallpoxGBinGBaGBboy,GBusingGBmaterialGBfromGBtheGBcowpoxGBpustulesGBofGBaGBmi
lkmaid.GBInGB1980,GBsmallpoxGBwasGBreportedGBtoGBbeGBeradicatedGBworldwideGBbyGBaGBvaccinat
ionGBprogram.GBEffectiveGBvaccinesGBagainstGBtetanusGBtoxin,GBrubellaGBvirus,GBandGBpoliovirusG
BwereGBdevelopedGBinGBtheGB20thGBcenturyGBandGBareGBwidelyGBused.GBThereGBisGBnoGBeffectiveGB
vaccineGBagainstGBMycobacteriumGBtuberculosis.
3. WhichGBofGBtheGBfollowingGBisGBaGBuniqueGBpropertyGBofGBtheGBadaptiveGBimmuneGBsystem?
a. HighlyGBdiverseGBrepertoireGBofGBspecificitiesGBforGBantigens
b. Self-nonselfGBdiscrimination
c. RecognitionGBofGBmicrobialGBstructuresGBbyGBbothGBcell-associatedGBandGBsolubleGBreceptors
d. ProtectionGBagainstGBviralGBinfections
e. ResponsesGBthatGBhaveGBtheGBsameGBkineticsGBandGBmagnitudeGBonGBrepeatedGBexposur
eGBtoGBtheGBsameGBmicrobe
ANS:G B A
, HighlyGBdiverseGBrepertoiresGBofGBspecificitiesGBforGBantigensGBareGBfoundGBonlyGBinGBTGBandGBB
GBlymphocytes,GBwhichGBareGBtheGBcentralGBcellularGBcomponentsGBofGBtheGBadaptiveGBimmuneGB
system.GBBothGBtheGBinnateGBandGBtheGBadaptiveGBimmuneGBsystemsGBuseGBcell-
associatedGBandGBsolubleGBreceptorsGBtoGBrecognizeGBmicrobes,GBdisplayGBsomeGBdegreeGBofGBsel
f-
nonselfGBdiscrimination,GBandGBprotectGBagainstGBviruses.GBOnGBrepeatedGBexposureGBtoGBtheGBsa
meGBmicrobe,GBtheGBadaptiveGBimmuneGBresponseGBbecomesGBmoreGBrapidGBandGBofGBgreaterGBm
agnitude;GBthisGBisGBtheGBmanifestationGBofGBmemory.
4. AntibodiesGBandGBTGBlymphocytesGBareGBtheGBrespectiveGBmediatorsGBofGBwhichGBtwoGB
typesGBofGBimmunity?
a. InnateGBandGBadaptive
b. PassiveGBandGBactive
c. SpecificGBandGBnonspecific
d. HumoralGBandGBcell-mediated
e. AdultGBandGBneonatal
ANS:G B D
BothGBBGBandGBTGBlymphocytesGBareGBprincipalGBcomponentsGBofGBadaptiveGBimmunity.GBBGBlym
phocytesGBproduceGBantibodies,GBwhichGBareGBtheGBrecognitionGBandGBeffectorGBmoleculesGBofGBh
umoralGBimmuneGBresponsesGBtoGBextracellularGBpathogens.GBTGBcellsGBrecognizeGBandGBpromote
GBeradicationGBofGBintracellularGBpathogensGBinGBcell-
mediatedGBimmunity.GBPassiveGBandGBactiveGBimmunityGBbothGBcanGBbeGBmediatedGBbyGBeitherGBBG
BorGBTGBlymphocytes.GBSpecificGBimmunityGBisGBanotherGBtermGBforGBadaptiveGBimmunity.GBBothGB
BGBandGBTGBlymphocytesGBparticipateGBinGBadultGBadaptiveGBimmunityGBbutGBareGBstillGBdevelopin
gGBinGBtheGBneonatalGBperiod.
5. TheGBtwoGBmajorGBfunctionalGBclassesGBofGBeffectorGBTGBlymphocytesGBare:
a. HelperGBTGBlymphocytesGBandGBcytotoxicGBTGBlymphocytes
b. NaturalGBkillerGBcellsGBandGBcytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
c. MemoryGBTGBcellsGBandGBeffectorGBTGBcells
d. HelperGBcellsGBandGBantigen-presentingGBcells
e. CytotoxicGBTGBlymphocytesGBandGBtargetGBcells
ANS:G B A
TGBcellsGBcanGBbeGBclassifiedGBintoGBeffectorGBsubsetsGBthatGBperformGBdifferentGBeffectorGBfunctio
ns.GBMostGBeffectorGBTGBcellsGBareGBeitherGBhelperGBTGBlymphocytes,GBwhichGBenhanceGBtheGBres
ponsesGBofGBotherGBimmuneGBcells,GBincludingGBphagocytesGBandGBBGBcells,GBtoGBinfections,GBorG
BcytotoxicGBTGBlymphocytes,GBwhichGBdirectlyGBkillGBinfectedGBcells.GBNaturalGBkillerGBcellsGBare
GBnotGBTGBlymphocytes.
Antigen-
presentingGBcellsGBusuallyGBareGBnotGBTGBcells.GBMemoryGBTGBcellsGBareGBnotGBeffectorGBTGBcells.
6. WhichGBofGBtheGBfollowingGBcellGBtypesGBisGBrequiredGBforGBallGBadaptiveGBhumoralGBimmuneGBresponse
s?
a. NaturalGBkillerGBcells
b. DendriticGBcells
c. CytolyticGBTGBlymphocytes
d. BGBlymphocytes
e. HelperGBTGBlymphocytes
ANS:G B D
HumoralGBimmuneGBresponsesGBareGBantibody-
mediatedGBimmuneGBresponses,GBandGBallGBantibodiesGBareGBmadeGBbyGBBGBlymphocytesGBandG
