Methotrexate for Osteoporosis and Rheumatoid
Arthritis – Therapeutic Uses, Administration, and
Nursing Management
Bisphosphonates
Alendronate
THERAPEUTIC USE of Alendronate
Prevention and treatment of postmenopausal osteoporosis, glucocorticoid-related
osteoporosis, and age-related osteoporosis in clients who are assigned male at birth.
ADVERSE DRUG REACTIONS of Alendronate
Esophagitis, gastrointestinal disturbances (nausea and vomiting, abdominal pain), muscle and
joint pain, eye pain and vision changes.
INTERVENTIONS for Alendronate
Give medication with 6 to 8 oz of water; have clients remain in upright position for 30 min
after taking medication; avoid eating or drinking anything other than water; avoid giving
calcium supplement or antacid; give analgesic for muscle and joint pain; monitor clients for
changes in vision.
ADMINISTRATION of Alendronate
Give medication 30 min before breakfast with a full glass of water; have client sit or stand for
30 min after administration; avoid giving calcium-containing medications/supplements within
30 min of administration.
CLIENT INSTRUCTIONS for Alendronate
Instruct clients to take medication with full glass of water; sit or stand up for 30 min after
taking medication; avoid eating or drinking anything other than water; avoid taking calcium
supplement or antacid; advise clients to take analgesic for muscle and joint pain and report
pain that persists; instruct clients to report changes in swallowing or vision to provider.
CONTRAINDICATIONS for Alendronate
Esophageal strictures/disorders or difficulty swallowing, clients unable to sit up for 30 min
after administration, renal insufficiency, hypocalcemia.