ESTUDYR
NSG 552 – Exam 3
Psychopharmacology & Neurocognitive Disorders
Intensive NCLEX-Style Practice Exam (Questions 1–91)
1. Naloxone is administered to a patient with suspected opioid overdose. Which mechanism
best explains how naloxone reverses opioid toxicity?
A. Partial activation of opioid receptors
�B. Competitive antagonism at opioid receptors
C. Increasing endogenous endorphins
D. Inhibiting opioid metabolism
Rationale: Naloxone is a pure opioid antagonist that competitively displaces opioids from
receptor sites, reversing respiratory and CNS depression.
2. Which medications are FDA-approved for the treatment of opioid use disorder (OUD)?
A. Naltrexone only
B. Naloxone and methadone
�C. Methadone, buprenorphine, and buprenorphine/naloxone
D. Diazepam and clonidine
Rationale: MOUD includes methadone, buprenorphine, and buprenorphine combined with
naloxone.
3. Which medication is most appropriate for a patient with opioid use disorder who also has
chronic pain?
A. Naltrexone
B. Naloxone
�C. Buprenorphine/naloxone
D. Disulfiram
Rationale: Buprenorphine provides partial opioid agonism, allowing pain control while
reducing misuse risk.
,ESTUDYR
4. Inappropriate use of which substance may reflect poorly controlled chronic pain rather
than addiction alone?
A. Benzodiazepines
B. Alcohol
�C. Opioids
D. Stimulants
Rationale: Pseudoaddiction may occur when pain is undertreated, leading to opioid misuse
behaviors.
5. Which are approved delivery methods for naltrexone?
A. Oral only
B. Injectable only
�C. Tablet, injectable, and implant
D. Patch and inhalation
Rationale: Naltrexone is available in oral, long-acting injectable, and implant formulations.
6. Which form of naltrexone delivery is limited to inpatient or highly supervised settings?
A. Tablet
B. Injection
�C. Implant
D. Sublingual
Rationale: Implants require procedural placement and close monitoring.
7. Buprenorphine treats opioid withdrawal primarily through which mechanism?
A. Full opioid agonism
B. Opioid antagonism
�C. Partial mu-opioid receptor agonism
D. NMDA antagonism
Rationale: Partial agonism reduces withdrawal while limiting euphoria and respiratory
depression.
, ESTUDYR
8. Which medication can precipitate severe, rapid opioid withdrawal if taken too soon after
opioid use?
A. Naloxone
B. Methadone
�C. Buprenorphine
D. Naltrexone
Rationale: Buprenorphine displaces full agonists, causing precipitated withdrawal.
9. Which constellation of findings is MOST consistent with opioid intoxication?
A. Dilated pupils, hypertension, agitation
�B. Miosis, respiratory depression, sedation
C. Hyperthermia and tremors
D. Hallucinations and paranoia
Rationale: Pinpoint pupils and respiratory depression are classic opioid toxicity signs.
10. Which symptom profile best represents opioid withdrawal?
A. Constipation and miosis
B. Sedation and euphoria
�C. Diarrhea, lacrimation, rhinorrhea, dilated pupils
D. Bradycardia and hypothermia
Rationale: Withdrawal produces autonomic hyperactivity, opposite of intoxication.
11. Naloxone should be administered immediately when opioid intoxication causes:
A. Constipation
B. Euphoria
�C. Respiratory or cardiac depression
D. Anxiety
Rationale: Naloxone is life-saving in respiratory compromise.
NSG 552 – Exam 3
Psychopharmacology & Neurocognitive Disorders
Intensive NCLEX-Style Practice Exam (Questions 1–91)
1. Naloxone is administered to a patient with suspected opioid overdose. Which mechanism
best explains how naloxone reverses opioid toxicity?
A. Partial activation of opioid receptors
�B. Competitive antagonism at opioid receptors
C. Increasing endogenous endorphins
D. Inhibiting opioid metabolism
Rationale: Naloxone is a pure opioid antagonist that competitively displaces opioids from
receptor sites, reversing respiratory and CNS depression.
2. Which medications are FDA-approved for the treatment of opioid use disorder (OUD)?
A. Naltrexone only
B. Naloxone and methadone
�C. Methadone, buprenorphine, and buprenorphine/naloxone
D. Diazepam and clonidine
Rationale: MOUD includes methadone, buprenorphine, and buprenorphine combined with
naloxone.
3. Which medication is most appropriate for a patient with opioid use disorder who also has
chronic pain?
A. Naltrexone
B. Naloxone
�C. Buprenorphine/naloxone
D. Disulfiram
Rationale: Buprenorphine provides partial opioid agonism, allowing pain control while
reducing misuse risk.
,ESTUDYR
4. Inappropriate use of which substance may reflect poorly controlled chronic pain rather
than addiction alone?
A. Benzodiazepines
B. Alcohol
�C. Opioids
D. Stimulants
Rationale: Pseudoaddiction may occur when pain is undertreated, leading to opioid misuse
behaviors.
5. Which are approved delivery methods for naltrexone?
A. Oral only
B. Injectable only
�C. Tablet, injectable, and implant
D. Patch and inhalation
Rationale: Naltrexone is available in oral, long-acting injectable, and implant formulations.
6. Which form of naltrexone delivery is limited to inpatient or highly supervised settings?
A. Tablet
B. Injection
�C. Implant
D. Sublingual
Rationale: Implants require procedural placement and close monitoring.
7. Buprenorphine treats opioid withdrawal primarily through which mechanism?
A. Full opioid agonism
B. Opioid antagonism
�C. Partial mu-opioid receptor agonism
D. NMDA antagonism
Rationale: Partial agonism reduces withdrawal while limiting euphoria and respiratory
depression.
, ESTUDYR
8. Which medication can precipitate severe, rapid opioid withdrawal if taken too soon after
opioid use?
A. Naloxone
B. Methadone
�C. Buprenorphine
D. Naltrexone
Rationale: Buprenorphine displaces full agonists, causing precipitated withdrawal.
9. Which constellation of findings is MOST consistent with opioid intoxication?
A. Dilated pupils, hypertension, agitation
�B. Miosis, respiratory depression, sedation
C. Hyperthermia and tremors
D. Hallucinations and paranoia
Rationale: Pinpoint pupils and respiratory depression are classic opioid toxicity signs.
10. Which symptom profile best represents opioid withdrawal?
A. Constipation and miosis
B. Sedation and euphoria
�C. Diarrhea, lacrimation, rhinorrhea, dilated pupils
D. Bradycardia and hypothermia
Rationale: Withdrawal produces autonomic hyperactivity, opposite of intoxication.
11. Naloxone should be administered immediately when opioid intoxication causes:
A. Constipation
B. Euphoria
�C. Respiratory or cardiac depression
D. Anxiety
Rationale: Naloxone is life-saving in respiratory compromise.
