Blood Bank Board Exam Questions
and Answers | Latest Version |
2025/2026 | Correct & Verified
What is the primary purpose of ABO blood grouping in transfusion practice?
✔✔To ensure compatibility and prevent hemolytic transfusion reactions.
Which blood group antigen system is most clinically significant after ABO?
✔✔Rh (Rhesus) system.
What type of antibody is primarily involved in ABO reactions?
✔✔IgM antibodies.
What immunoglobulin class is most often responsible for hemolytic disease of the fetus and
newborn (HDFN)?
✔✔IgG antibodies.
What is the universal donor blood type for red blood cell transfusions?
✔✔Group O Rh-negative.
What is the universal recipient blood type for red blood cell transfusions?
✔✔Group AB Rh-positive.
1
,What laboratory test is used to detect unexpected antibodies in a patient’s serum?
✔✔Antibody screen.
What test confirms the specificity of an antibody detected in screening?
✔✔Antibody identification panel.
What is the purpose of a crossmatch test?
✔✔To ensure donor red cells are compatible with the recipient’s serum.
What does a positive direct antiglobulin test (DAT) indicate?
✔✔Antibodies or complement bound to red blood cells in vivo.
What does an indirect antiglobulin test (IAT) detect?
✔✔Free antibodies in patient serum.
What preservative solution extends the shelf life of stored red blood cells?
✔✔CPDA-1 (Citrate Phosphate Dextrose Adenine).
What is the standard storage temperature range for red blood cell units?
✔✔1°C to 6°C.
What blood component is most effective for treating thrombocytopenia?
2
,✔✔Platelets.
What is the typical storage temperature for platelet units?
✔✔20°C to 24°C with continuous agitation.
What blood component is used to treat coagulation factor deficiencies?
✔✔Fresh frozen plasma (FFP).
What is the main indication for cryoprecipitate transfusion?
✔✔Fibrinogen deficiency.
Which infectious disease is most strictly screened in blood donors worldwide?
✔✔HIV.
What pathogen is most commonly associated with bacterial contamination of platelets?
✔✔Staphylococcus species.
What is the maximum shelf life of frozen plasma?
✔✔Up to one year at −18°C or colder.
Which antigen is responsible for Rh incompatibility in pregnancy?
✔✔D antigen.
3
, What prophylactic treatment prevents Rh sensitization in Rh-negative mothers?
✔✔Rho(D) immune globulin.
What is the primary cause of febrile non-hemolytic transfusion reactions?
✔✔Cytokines or leukocyte antibodies.
What blood product modification reduces febrile reactions?
✔✔Leukoreduction.
What is transfusion-related acute lung injury (TRALI)?
✔✔Acute respiratory distress caused by donor antibodies.
What is transfusion-associated circulatory overload (TACO)?
✔✔Volume overload from rapid transfusion.
What is the most common cause of acute hemolytic transfusion reactions?
✔✔ABO incompatibility.
What is the primary function of the Kell blood group system?
✔✔Expression of antigens involved in red cell membrane structure.
4
and Answers | Latest Version |
2025/2026 | Correct & Verified
What is the primary purpose of ABO blood grouping in transfusion practice?
✔✔To ensure compatibility and prevent hemolytic transfusion reactions.
Which blood group antigen system is most clinically significant after ABO?
✔✔Rh (Rhesus) system.
What type of antibody is primarily involved in ABO reactions?
✔✔IgM antibodies.
What immunoglobulin class is most often responsible for hemolytic disease of the fetus and
newborn (HDFN)?
✔✔IgG antibodies.
What is the universal donor blood type for red blood cell transfusions?
✔✔Group O Rh-negative.
What is the universal recipient blood type for red blood cell transfusions?
✔✔Group AB Rh-positive.
1
,What laboratory test is used to detect unexpected antibodies in a patient’s serum?
✔✔Antibody screen.
What test confirms the specificity of an antibody detected in screening?
✔✔Antibody identification panel.
What is the purpose of a crossmatch test?
✔✔To ensure donor red cells are compatible with the recipient’s serum.
What does a positive direct antiglobulin test (DAT) indicate?
✔✔Antibodies or complement bound to red blood cells in vivo.
What does an indirect antiglobulin test (IAT) detect?
✔✔Free antibodies in patient serum.
What preservative solution extends the shelf life of stored red blood cells?
✔✔CPDA-1 (Citrate Phosphate Dextrose Adenine).
What is the standard storage temperature range for red blood cell units?
✔✔1°C to 6°C.
What blood component is most effective for treating thrombocytopenia?
2
,✔✔Platelets.
What is the typical storage temperature for platelet units?
✔✔20°C to 24°C with continuous agitation.
What blood component is used to treat coagulation factor deficiencies?
✔✔Fresh frozen plasma (FFP).
What is the main indication for cryoprecipitate transfusion?
✔✔Fibrinogen deficiency.
Which infectious disease is most strictly screened in blood donors worldwide?
✔✔HIV.
What pathogen is most commonly associated with bacterial contamination of platelets?
✔✔Staphylococcus species.
What is the maximum shelf life of frozen plasma?
✔✔Up to one year at −18°C or colder.
Which antigen is responsible for Rh incompatibility in pregnancy?
✔✔D antigen.
3
, What prophylactic treatment prevents Rh sensitization in Rh-negative mothers?
✔✔Rho(D) immune globulin.
What is the primary cause of febrile non-hemolytic transfusion reactions?
✔✔Cytokines or leukocyte antibodies.
What blood product modification reduces febrile reactions?
✔✔Leukoreduction.
What is transfusion-related acute lung injury (TRALI)?
✔✔Acute respiratory distress caused by donor antibodies.
What is transfusion-associated circulatory overload (TACO)?
✔✔Volume overload from rapid transfusion.
What is the most common cause of acute hemolytic transfusion reactions?
✔✔ABO incompatibility.
What is the primary function of the Kell blood group system?
✔✔Expression of antigens involved in red cell membrane structure.
4
