Pathophysiology Actual Week 8 Final
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Asthma -CORRECTANSWER Chronic disease due to bronchoconstriction and an
excessive inflammatory response in the bronchioles
What are 5 s/s of asthma -CORRECTANSWER coughing
wheezing
shortness of breath
rapid breathing
chest tightness
Pathophysiology of asthma (5) -CORRECTANSWER -airway inflammation, bronchial
hyper-reactivity and smooth muscle spasm
-excess mucus production and accumulation
-hypertrophy of bronchial smooth muscle
-airflow obstruction
-decreased alveolar ventilation
,Bronchioles -CORRECTANSWER smaller passageways that originate from the bronchi
that become the alveoli
3 layers of the bronchioles -CORRECTANSWER innermost layer
middle layer - lamina propria
outermost layer
lamina propria -CORRECTANSWER the middle layer of the bronchioles
structure of the lamina propria -CORRECTANSWER embedded with connective tissue
cells and immune cells
purpose of the lamina propria -CORRECTANSWER white blood cells are present to
help protect the airways
How does the lamina propria effect the lungs in regards to asthma -
CORRECTANSWER the WBCs protective feature goes into overdrive causing an
inflammatory response that damages host tissue
What does the innermost layer of the bronchioles contain -CORRECTANSWER
columnar epithelial ells and mucus producing goblet cells
,What does the outermost layer of the bronchioles contain -CORRECTANSWER smooth
muscle cells
what does the outermost layer of the bronchioles do -CORRECTANSWER control the
airways ability to constrict and dilate
alveolar hyperinflation -CORRECTANSWER When air is unable to move out of the
alveolar like it should due to bronchial walls collapsing around possible mucus plug thus
trapping air inside
how does hyperinflation occur? -CORRECTANSWER the ongoing inflammatory
process of asthma produces mucus and pus plug that the bronchial walls collapse
around
Effect of hyperinflation of the alveolar -CORRECTANSWER -expanded thorax and
hypercapnia (retention of CO2)
- respiratory acidosis
What are two anticholinergic drugs used for asthma -CORRECTANSWER tiotropium
and ipratropium
What do anticholinergics do in the lungs? -CORRECTANSWER These drugs block the
effects of the parasympathetic nervous system
, - increasing bronchodilation
MOA of anticholinergic drugs for asthma -CORRECTANSWER the parasympathetic
system is stimulated by the vagal nerve to release acetylcholine which binds to the
cholinergic receptors of the respiratory tract to cause bronchial constriction = decreased
airflow
- blocking the cholinergic receptors prevents acetylcholine binding preventing the
bronchial constriction
bronchitis -CORRECTANSWER inflammation of the bronchial tubes
3 characteristics of bronchitis -CORRECTANSWER bronchial inflammation
hypersecretion of mucus
chronic productive cough for at least 3 consecutive months for at least 2 successive
years
Perfusion -CORRECTANSWER The supply of oxygen to and removal of wastes from
the cells and tissues of the body as a result of the flow of blood through the capillaries.
results of chronic bronchitis/ low perfusion -CORRECTANSWER cyanosis
right to left shunting
chronic hypoxemia