TEST BANK For Kuby Immunology With Covid-19 & Digital
Update,EXAM
The germinal centers found in the cortical region of lymph nodes and the peripheral region of splenic
periarteriolar lymphatic tissue: - answercontains large populations of B lymphocytes and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections. Thus, in
case of Mycobacterium leprae infection: - answertuberculoid leprosy will occur in patients with a
prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands on APCs.
The MHC molecule located around the peptide-binding cleft is recognized by the: - answerCD4 or CD8
molecules
The edema occurring in the inflammatory process is the result of all the following factors EXCEPT: -
answerneural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - answerrecognize pathogen-associated molecular patterns (PAMPs) on
selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands on APCs.
The T cell receptor transduction molecule(s) is(are) conducted by: - answerCD3 and ζ molecules
Which of the following is considered a primary lymphoid organ? - answerthymus
Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - answerMHC class II molecules
Immunologic memory refers to: - answerchanges in adaptive immune responses with subsequent
encounters with antigen
,Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells express which
adhesion molecule to mediate their migration into lymph nodes through specialized vessels called high
endothelial venues (HEVs)? - answerL-selectin
The main consequences of complement activation are all of the following EXCEPT: - answerproducing
2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - answerdendritic cells located mainly in
the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte zone)
EXCEPT: - answershort-lived plasma cells
The antigen recognition on the T cells is mediated by: - answerthe Variable (v) regions of α and β chains
The T-cell receptor: - answerrecognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? - answerClones of
lymphocytes specific for antigens develop prior to exposure to the antigens
Which of the following best describes the T-dependent antibody response? - answerIT is the response of
follicular B lymphocytes to a protein antigen and characterized by isotope-switched, high affinity
antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - answerOne α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the following
EXCEPT: - answerantigen presentation to the T cells in the follicles of the lymph nodes
The phases and order of the specific or acquired immune responses are: - answerrecognition phase;
activation phase; effector phase; homeostasis phase; memory phase
, A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit and
activate different cell types. The IFN-γ is produced mainly by: - answerCD4+ T cell TH1 subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage and B
lymphocytes by: - answerCD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J gene
segments in different clones of lymphocytes is the result of: - answerboth combinatorial diversity and
junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: - answerrecognizes
antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was infected
with rabies virus, is administration of human immunoglobulin preparations containing anti-rabies virus
antibodies. Which type of immunity would be established by this treatment? - answerpassive humoral
immunity
The steps in the activation of T lymphocytes against a specific antigen takes place int he following order:
- answerantigen recognition, activation, clonal expansion, differentiation into effector cells & memory
cells
Antigen recognition by T cells induces signal transduction through biochemical intermediates which will
activate enzymes responsible for activation of Transcriptional Factors. This activation may be blocked
by: - answercyclosporine
The CD8+ cytolytic T lymphocyte (CTL) uses different mechanisms to kill the target cell. Caspase-
activating proteins of the CTL granules are called: - answergranzyme B
Regarding the recognition of microbes by innate immune system, all of the following are true EXCEPT: -
answerthe innate system responds more efficiently to each successive encounter with a microbe
Update,EXAM
The germinal centers found in the cortical region of lymph nodes and the peripheral region of splenic
periarteriolar lymphatic tissue: - answercontains large populations of B lymphocytes and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections. Thus, in
case of Mycobacterium leprae infection: - answertuberculoid leprosy will occur in patients with a
prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands on APCs.
The MHC molecule located around the peptide-binding cleft is recognized by the: - answerCD4 or CD8
molecules
The edema occurring in the inflammatory process is the result of all the following factors EXCEPT: -
answerneural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - answerrecognize pathogen-associated molecular patterns (PAMPs) on
selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands on APCs.
The T cell receptor transduction molecule(s) is(are) conducted by: - answerCD3 and ζ molecules
Which of the following is considered a primary lymphoid organ? - answerthymus
Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - answerMHC class II molecules
Immunologic memory refers to: - answerchanges in adaptive immune responses with subsequent
encounters with antigen
,Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells express which
adhesion molecule to mediate their migration into lymph nodes through specialized vessels called high
endothelial venues (HEVs)? - answerL-selectin
The main consequences of complement activation are all of the following EXCEPT: - answerproducing
2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - answerdendritic cells located mainly in
the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte zone)
EXCEPT: - answershort-lived plasma cells
The antigen recognition on the T cells is mediated by: - answerthe Variable (v) regions of α and β chains
The T-cell receptor: - answerrecognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? - answerClones of
lymphocytes specific for antigens develop prior to exposure to the antigens
Which of the following best describes the T-dependent antibody response? - answerIT is the response of
follicular B lymphocytes to a protein antigen and characterized by isotope-switched, high affinity
antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - answerOne α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the following
EXCEPT: - answerantigen presentation to the T cells in the follicles of the lymph nodes
The phases and order of the specific or acquired immune responses are: - answerrecognition phase;
activation phase; effector phase; homeostasis phase; memory phase
, A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit and
activate different cell types. The IFN-γ is produced mainly by: - answerCD4+ T cell TH1 subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage and B
lymphocytes by: - answerCD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J gene
segments in different clones of lymphocytes is the result of: - answerboth combinatorial diversity and
junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: - answerrecognizes
antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was infected
with rabies virus, is administration of human immunoglobulin preparations containing anti-rabies virus
antibodies. Which type of immunity would be established by this treatment? - answerpassive humoral
immunity
The steps in the activation of T lymphocytes against a specific antigen takes place int he following order:
- answerantigen recognition, activation, clonal expansion, differentiation into effector cells & memory
cells
Antigen recognition by T cells induces signal transduction through biochemical intermediates which will
activate enzymes responsible for activation of Transcriptional Factors. This activation may be blocked
by: - answercyclosporine
The CD8+ cytolytic T lymphocyte (CTL) uses different mechanisms to kill the target cell. Caspase-
activating proteins of the CTL granules are called: - answergranzyme B
Regarding the recognition of microbes by innate immune system, all of the following are true EXCEPT: -
answerthe innate system responds more efficiently to each successive encounter with a microbe
