PCOL 825 Regan Exam 1 Questions and Answers (100% Correct Answers) Already Graded A+

1




PCOL 825 Regan Exam 1 Questions
and Answers (100% Correct
Answers) Already Graded A+


Biosynthesis of histamine Ans: Histidine--->histamine (via
decarboxylation of histidine)
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-synthesized in mast cells, basophils, eosinophils,
enterochromaffin-like cells (stomach), histaminergic neurons
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in CNS
Expert




-targets receptors H1-H4


H1 receptors Ans: CNS:


-promotes wakefulness, decreased appetite, motion sickness,
emesis


Periphery: (skin, vascular/bronchial smooth muscle,
endothelium)


-bronchoconstriction, vasodilation, increased vascular
permeability, edema, increased nociception, itch, urticaria


Pathophysiological effect of histamine Ans: -Acute
inflammatory response, itching/urticaria


- Immediate IgE-mediated hypersensitivity reaction

- Bronchospasm

, 2


- Tachycardia

- Angioedema


- Hypotension, anaphylaxis


- IgE-mediated reactions related to inhaled respiratory
allergens involved with asthma


- Seasonal allergies/allergic rhinitis
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- Non-immune hypersensitivity reaction
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- Increased gastric acid secretion


Ig-E mediated histamine release Ans: -food allergens


-drug allergens


venom


-foreign proteins (serum proteins, biologics)

-inhaled respiratory allergens (asthma)


T/B cells generate IGE release and attach to surface of mast
cells=> mast cells degranulate releasing allergic mediators


non-immune mediated histamine release Ans: - I.V. morphine
and other opiates


- Aspirin and some NSAIDs