PCOL 473 Quiz 1 Questions and
Answers (100% Correct Answers)
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Drug Ans: a xenobiotic administered with the intent of a
biologic effect
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pharmacogenomics Ans: a research area that studies how an
individuals unique composition of inherited and acquired gene
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variation impacts their response to medication
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pharamaco Ans: related to drugs
gene Ans: functional unit of heredity, DNA
-omics Ans: jargon for a comprehensive analysis of a
biologic/chemical analyte (genes)
Karyotype Ans: the characterization of chromosomal
complement of an individual
SNP Ans: single nucleotide polymorphism
-DNA variants that occur naturally across the human genome
VDR Ans: variable drug response
different effect on different people
, 2
-long term goal is to minimize toxicity, maximize efficacy,
accurately predict theraputic response to an intervention
"the most common drug adverse is the failure of the drug to do
what you want it to do"
cellular molecules that have been successfully targeted by
therapeutic agents (5) Ans: 1. cell plasma membrane
receptors
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2. nuclear receptors
3. DNA/RNA
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4. ion channels
5. enzymes (intra/extracellular)
6. Carrier proteins
Central Dogma of Molecular Biology Ans: DNA -> RNA ->
Protein
(Replication-> Transcription-> Translation)
Purines Ans: Adenine and Guanine
double ring structure
Pyrimidines Ans: Cytosine and Thymine
single ring
The sugar in DNA is: Ans: deoxyribose