PCOL 825 Exam 1 Vaillancourt
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Glucocorticoids Ans: cortisol (most common)
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-increases availability of glucose & plasma glucose levels
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Secretion regulated by:
Expert
1. stress
2. circadian rhythm
3. meals
4. hyperthyroidism
Mineralcorticoids Ans: Aldosterone
-increase Na reabsorption
-secretion regulated by angiotensin II
-Na and H2O retention in kidney (eNAC)
-increase excretion of K+ and H+
Adrenal Androgens Ans: Androstenedione
, 2
Pubic and axillary hair development
Bone maturation
Cholesterol ester --> cholesterol via (esterase ACTH)
Adrenaocortical hormone actions Ans: regulate gene
transcription
[mineralocorticoid receptor + aldosterone]
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Stress-like responses:
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1. Metabolism: Increase serum glucose, decrease glucose and
adipose/muscle ?
-increase lipolysis and fat redistribution (cushing's moon
face/potbelly/buffalo hump)
-increase protein breakdown (catabolism) of function as
precursor of glucose.
2. CNS: excitation and euphoria (opposes sleep)
3. Growth
-catabolic (bone breakdown)
-antagonizes vit D dependent Ca uptake in intestine
4. respiratory:
-increase lung maturation
, 3
-produce pulmonary surfactant for breathing
5. Cardiovascular
-decrease capillary permeability
-increase platelets and RBC
6. Immunity:
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-suppress inflammation
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-decreased eosinophils, basophils, monocytes, and
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lymphocytes (T and B cells)
-reduce antibody production
-suppress immunity against H. pylori=>peptic ulcers
Cushing's syndrome Ans: 1. hypersecretion of ACTH by
pituitary adenoma
2. hypersecretion of glucocorticoids by adrenal
adenomas/carcinomas
3. admin of high dose of glucocorticoids used to treat
asthma/arthritis (caused by treatment due to activation of
negative feedback loop)
Addison's Disease Ans: adrenal insufficiency
-occurs from sudden withdrawal of corticosteroid (steroid
production suppressed by chronic corticosteroid use)