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MRO Practice Exam – Medical Review Officer Exam Updated 2026/2027 | Actual Questions, Verified Answers, and Complete Solutions | Instant PDF Download

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This comprehensive MRO Practice Exam guide provides the latest updated 2026/2027 actual questions and verified answers for the Medical Review Officer certification. The document includes in-depth coverage of MRO responsibilities, DOT drug and alcohol testing regulations, 49 CFR Part 40 compliance, specimen collection procedures, verification of laboratory results, handling positive and negative drug tests, legitimate medical explanations, and interview protocols. Each question includes detailed rationales to reinforce understanding and prepare candidates for a guaranteed pass in the MRO exam. This guide is essential for healthcare professionals, MRO candidates, and compliance officers seeking thorough exam preparation.

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MRO PRACTICE EXAM - MEDICAL REVIEW
OFFICER EXAM ACTUAL QUESTIONS AND
ANSWERS - LATEST AND COMPLETE UPDATE
WITH VERIFIED SOLUTIONS – ASSURED PASS
WITH INSTANT DOWNLOAD PDF.
1. A Medical Review Officer’s primary responsibility in the drug testing
process is to:
A. Collect biological specimens
B. Administer employer drug policies
C. Verify laboratory drug test results and ensure medical legitimacy
D. Discipline employees based on results
*Rationale: The MRO acts as an independent medical authority who reviews
lab results, interviews donors, and determines whether a legitimate medical
explanation exists.
2. Under DOT regulations, an MRO must be:
A. Any licensed healthcare worker
B. A licensed physician (MD or DO) with specific MRO training
C. A certified laboratory scientist
D. An occupational health nurse
*Rationale: DOT requires MROs to be licensed physicians with documented
MRO qualification training and testing.
3. Which regulation primarily governs DOT drug and alcohol testing?
A. HIPAA
B. OSHA 1910
C. 49 CFR Part 40
D. CLIA

, *Rationale: 49 CFR Part 40 establishes procedures for DOT workplace
drug and alcohol testing.
4. A donor tests positive for morphine. During the interview, the donor reports
a recent prescription for codeine. The MRO should:
A. Cancel the test
B. Report a positive result
C. Verify the result as negative if prescription is legitimate
D. Require a repeat collection
*Rationale: Codeine metabolizes to morphine; a valid prescription provides
a legitimate medical explanation.
5. Which substance is included in the DOT 5-panel drug test?
A. Benzodiazepines
B. Barbiturates
C. Marijuana (THC)
D. Synthetic cannabinoids
*Rationale: The DOT panel includes marijuana, cocaine, opiates,
amphetamines, and PCP.
6. A “refusal to test” determination is ultimately made by:
A. The collector
B. The employer
C. The MRO (for drug tests)
D. The laboratory
*Rationale: For drug testing, the MRO determines refusal outcomes based
on regulatory criteria.
7. When must an MRO contact a donor after receiving a laboratory positive
result?
A. Within 72 hours

, B. Before notifying the employer
C. Before verifying the result
D. Only if the donor requests it
*Rationale: The MRO must attempt to contact the donor to discuss results
prior to verification.
8. If a donor cannot be reached after reasonable efforts, the MRO should:
A. Cancel the test immediately
B. Verify the result as positive after documenting contact attempts
C. Refer the donor for SAP evaluation
D. Order a recollection
*Rationale: Regulations allow verification after documented unsuccessful
contact attempts.
9. Which scenario requires a shy bladder procedure?
A. Temperature out of range
B. Insufficient urine volume
C. Positive adulterant
D. Split specimen failure
*Rationale: A shy bladder occurs when a donor cannot provide sufficient
urine.
10.An MRO may disclose drug test results to:
A. Any healthcare provider
B. Law enforcement
C. The employer’s designated representative (DER)
D. The donor’s coworkers
*Rationale: Disclosure is limited to authorized parties such as the DER.
11.A substituted specimen is best described as:
A. Urine containing an adulterant

, B. Urine inconsistent with human physiology
C. Dilute urine
D. Urine with low creatinine only
*Rationale: Substitution indicates urine that is not consistent with normal
human urine.
12.Which action is appropriate if a laboratory reports an invalid result?
A. Verify as negative
B. Verify as positive
C. Cancel the test and order recollection when required
D. Report refusal
*Rationale: Invalid results cannot be verified and often require recollection.
13.An MRO must retain records for at least:
A. 1 year
B. 3 years
C. 5 years
D. 10 years
*Rationale: DOT regulations mandate a minimum five-year record
retention.
14.Which substance requires a Medical Marijuana card consideration?
A. Cocaine
B. None under DOT testing
C. PCP
D. Methamphetamine
*Rationale: DOT does not recognize medical marijuana as a legitimate
explanation.
15.A donor requests that results be sent to a personal attorney. The MRO
should:

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