Pathophysiology Actual Week 1-4 Midterm Exam Complete 1-
100 Exam Questions Proctored Via Examplify Chamberlain
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1. Which cellular change is considered a reversible injury?
A. Nuclear pyknosis
B. Mitochondrial rupture
C. Cellular swelling
D. Lysosomal membrane rupture
2. Apoptosis differs from necrosis because apoptosis:
A. Triggers inflammation
B. Is always pathologic
C. Results from ATP depletion
D. Is a regulated, energy-dependent process
3. An increase in the size of skeletal muscle fibers due to weight training is called:
A. Hyperplasia
B. Hypertrophy
C. Metaplasia
D. Dysplasia
4. Metaplasia is best described as:
A. Reversible cell swelling
B. Replacement of one differentiated cell type with another
C. Uncontrolled cell growth
D. Programmed cell death
5. Which condition most commonly leads to ischemic cellular injury?
A. Hypoglycemia
B. Hypoxia
C. Hyperkalemia
D. Hypercapnia
6. ATP depletion in cells primarily impairs which function first?
A. Protein synthesis
B. Cell membrane integrity
C. Sodium-potassium pump
D. DNA replication
,7. Which organ is most sensitive to hypoxic injury?
A. Liver
B. Kidney
C. Brain
D. Skeletal muscle
8. Caseous necrosis is classically associated with:
A. Myocardial infarction
B. Tuberculosis
C. Pancreatitis
D. Ischemic stroke
9. Which intracellular accumulation is associated with chronic alcohol use?
A. Lipofuscin
B. Hemosiderin
C. Glycogen
D. Triglycerides
10. Free radical damage primarily affects which cellular component?
A. Ribosomes
B. DNA and membranes
C. Lysosomes
D. Golgi apparatus
Questions 11–20: Inflammation & Immunity
11. Acute inflammation is characterized by:
A. Lymphocyte predominance
B. Fibrosis
C. Neutrophil migration
D. Granuloma formation
12. Which mediator causes vasodilation and increased vascular permeability?
A. Histamine
B. Platelet-activating factor
C. Bradykinin
D. Leukotrienes
13. Chronic inflammation differs from acute inflammation by the presence of:
A. Edema
B. Neutrophils
C. Macrophages and lymphocytes
D. Vasodilation
, 14. Which hypersensitivity reaction is IgE-mediated?
A. Type I
B. Type II
C. Type III
D. Type IV
15. An example of a Type II hypersensitivity reaction is:
A. Allergic rhinitis
B. Systemic lupus erythematosus
C. Graves disease
D. Contact dermatitis
16. Type IV hypersensitivity is mediated by:
A. IgG antibodies
B. Immune complexes
C. T lymphocytes
D. Mast cells
17. Which cytokine is most associated with fever?
A. IL-4
B. IL-10
C. TNF-α
D. IFN-γ
18. Granuloma formation is most closely related to:
A. Acute inflammation
B. Chronic inflammation
C. Type I hypersensitivity
D. Complement activation
19. Which component of innate immunity acts as the first physical barrier?
A. B lymphocytes
B. Complement proteins
C. Skin
D. Antibodies
20. Autoimmune diseases primarily result from failure of:
A. Innate immunity
B. Self-tolerance
C. Antigen presentation
D. Complement activation
Questions 21–30: Genetics & Neoplasia