MRCP PRACTICE EXAM PREPARATION
MRCP PRACTICE EXAM PREPARATION FOR 2025/2026 WITH
COMPLETE QUESTIONS AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) |BRAND NEW VERSION!!
A 45-year-old woman presented with right flank pain. She had a 4-year history of
hypertension and progressive cognitive impairment.
On examination, she had livedo reticularis and tenderness in the right flank. Her
BP was 185/105 mmHg. Urinalysis showed blood 3+, protein 1+.
Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-400)
serum creatinine 106 µmol/L (60-110)
What antibody test is most likely to be positive?
A: anticardiolipin
B: anticentromere
C: anti-glomerular basement membrane
D: antimitochondrial
E: anti-neutrophil cytoplasmic
E: anti-neutrophil cytoplasmic
A
A 37-year-old woman presented with a history of intermittent lightheadedness.
Examination was normal.ECG normal
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, MRCP PRACTICE EXAM PREPARATION
24-hour ambulatory ECG tracing
atrial and ventricular premature beats; nocturnal bradycardia and Mobitz type 1
atrioventricular block, and supraventricular tachycardia
Which abnormality on the 24-hour ambulatory ECG is clinically most important?
A: atrial premature beats
B: profound sleep-associated bradycardia
C: supraventricular tachycardia
D: transient Mobitz type 1 atrioventricular block
E: ventricular premature beats
E: ventricular premature beats
C
A 28-year-old man presented with a 1-month history of weight loss, abdominal
distension, flatulence and foul-smelling diarrhoea following a visit to India.
anti-tissue transglutaminase antibodies negative
stool cultures and microscopy negative
What is the most likely diagnosis?
A: acute HIV seroconversion illness
B: coeliac disease
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, MRCP PRACTICE EXAM PREPARATION
C: giardiasis
D: hookworm infection (ancylostomiasis)
E: viral gastroenteritis
C
A 30-year-old woman presented with a 6-month history of tremor and difficulty in
speaking.
On examination, she was found to have increased muscle tone in all four limbs,
bradykinesia and 4-cm hepatomegaly.
What laboratory finding would best support a diagnosis of Wilson's disease?
A: increased incorporation of radioactive copper into caeruloplasmin
B: low hepatic copper content
C: low serum caeruloplasmin concentration
D: low serum free copper concentration
E: low urine copper concentration
C
Question 10
What dietary substrate is broken down into glucose and galactose by the action of
intestinal enzymes?
A: fructose
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, MRCP PRACTICE EXAM PREPARATION
B: lactose
C: maltose
D: mannose
E: sucrose
B
A 16-year-old girl presented with non-scaly, discrete areas of hair loss on the
scalp. She had a past history of atopic eczema and had a number of depigmented
areas on her hands and around her eyes.
What is the most likely diagnosis?
A: alopecia areata
B: hypothyroidism
C: lupus erythematosus
D: seborrhoeic dermatitis
E: trichotillomania
A
A 65-year-old woman presented with a 12-hour history of the sudden onset of gait
unsteadiness, vomiting and headache, followed by increasing drowsiness.
What is the most likely diagnosis?
A: acute cerebellar haemorrhage
4|Page
MRCP PRACTICE EXAM PREPARATION FOR 2025/2026 WITH
COMPLETE QUESTIONS AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) |BRAND NEW VERSION!!
A 45-year-old woman presented with right flank pain. She had a 4-year history of
hypertension and progressive cognitive impairment.
On examination, she had livedo reticularis and tenderness in the right flank. Her
BP was 185/105 mmHg. Urinalysis showed blood 3+, protein 1+.
Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-400)
serum creatinine 106 µmol/L (60-110)
What antibody test is most likely to be positive?
A: anticardiolipin
B: anticentromere
C: anti-glomerular basement membrane
D: antimitochondrial
E: anti-neutrophil cytoplasmic
E: anti-neutrophil cytoplasmic
A
A 37-year-old woman presented with a history of intermittent lightheadedness.
Examination was normal.ECG normal
1|Page
, MRCP PRACTICE EXAM PREPARATION
24-hour ambulatory ECG tracing
atrial and ventricular premature beats; nocturnal bradycardia and Mobitz type 1
atrioventricular block, and supraventricular tachycardia
Which abnormality on the 24-hour ambulatory ECG is clinically most important?
A: atrial premature beats
B: profound sleep-associated bradycardia
C: supraventricular tachycardia
D: transient Mobitz type 1 atrioventricular block
E: ventricular premature beats
E: ventricular premature beats
C
A 28-year-old man presented with a 1-month history of weight loss, abdominal
distension, flatulence and foul-smelling diarrhoea following a visit to India.
anti-tissue transglutaminase antibodies negative
stool cultures and microscopy negative
What is the most likely diagnosis?
A: acute HIV seroconversion illness
B: coeliac disease
2|Page
, MRCP PRACTICE EXAM PREPARATION
C: giardiasis
D: hookworm infection (ancylostomiasis)
E: viral gastroenteritis
C
A 30-year-old woman presented with a 6-month history of tremor and difficulty in
speaking.
On examination, she was found to have increased muscle tone in all four limbs,
bradykinesia and 4-cm hepatomegaly.
What laboratory finding would best support a diagnosis of Wilson's disease?
A: increased incorporation of radioactive copper into caeruloplasmin
B: low hepatic copper content
C: low serum caeruloplasmin concentration
D: low serum free copper concentration
E: low urine copper concentration
C
Question 10
What dietary substrate is broken down into glucose and galactose by the action of
intestinal enzymes?
A: fructose
3|Page
, MRCP PRACTICE EXAM PREPARATION
B: lactose
C: maltose
D: mannose
E: sucrose
B
A 16-year-old girl presented with non-scaly, discrete areas of hair loss on the
scalp. She had a past history of atopic eczema and had a number of depigmented
areas on her hands and around her eyes.
What is the most likely diagnosis?
A: alopecia areata
B: hypothyroidism
C: lupus erythematosus
D: seborrhoeic dermatitis
E: trichotillomania
A
A 65-year-old woman presented with a 12-hour history of the sudden onset of gait
unsteadiness, vomiting and headache, followed by increasing drowsiness.
What is the most likely diagnosis?
A: acute cerebellar haemorrhage
4|Page
