Advanced Pharmacology – Module
8 Peptic Ulcer Disease (PUD)
Study Guide & Exam Review
Verified Questions Complete with
A+ Graded Rationales Latest
Updated 2026
What are the defense factors for PUD?
Mucus
- Forms a barrier to protect underlying cells from acid and pepsin.
Bicarbonate
- Neutralize hydrogen ions that penetrate the mucus.
Blood Flow
- Poor blood flow can lead to ischemia, cell injury, and vulnerability to attack.
Prostaglandins
- promote vasodilation
- Stimulate the secretion of mucus and bicarbonate
- Suppress the secretion of gastric acid.
What are the 3 causes of PUD?
1. Helicobacter pylori -positive ulcers
2. NSAID-induced ulcers
3. Stress ulcers.
What are the 3 ways antiulcer drugs work?
1. Eradicate h. pylori (antibiotics)
2. Reduce gastric acidity (antisecretory agents, misoprostol)
3. Enhance mucosa defenses (sucralfate , misoprostol)
, What are the classes of Antiulcer Drugs?
Antibiotics
Antisecretory agents
Mucosal protectants
Antisecretory agents that enhance mucosal defenses
Antacids
What are differenced in treatment H. pylori induced and NSAID induced ulcers?
PUD Ulcers: 14-day, quadruple therapy
PPI + Bismuth + Metronidazole + Tetracycline
PPI + Amoxicillin + Metronidazole + Clarithromycin
NSAID Ulcers
- Identify an alternative for pain management or provide prophylaxis strategies
- Enteric-coated NSAIDs
- Take with meals
- Add misoprostol, or switching to a selective COX-2 inhibitor.
How is healing of ulcers monitored?
-Monitor for relief of pain.
-Radiologic or endoscopic examination of the ulcer site.
What level does gastric PH need to be to decrease Pepsin activity?
pH > 5
What are the 3 types of H. pylori testing?
Breath test
Serologic test
Stool test
What is the minimum number of antibiotics to treat PUD?
2
What are the drugs used to treat PUD?
Antibiotics
8 Peptic Ulcer Disease (PUD)
Study Guide & Exam Review
Verified Questions Complete with
A+ Graded Rationales Latest
Updated 2026
What are the defense factors for PUD?
Mucus
- Forms a barrier to protect underlying cells from acid and pepsin.
Bicarbonate
- Neutralize hydrogen ions that penetrate the mucus.
Blood Flow
- Poor blood flow can lead to ischemia, cell injury, and vulnerability to attack.
Prostaglandins
- promote vasodilation
- Stimulate the secretion of mucus and bicarbonate
- Suppress the secretion of gastric acid.
What are the 3 causes of PUD?
1. Helicobacter pylori -positive ulcers
2. NSAID-induced ulcers
3. Stress ulcers.
What are the 3 ways antiulcer drugs work?
1. Eradicate h. pylori (antibiotics)
2. Reduce gastric acidity (antisecretory agents, misoprostol)
3. Enhance mucosa defenses (sucralfate , misoprostol)
, What are the classes of Antiulcer Drugs?
Antibiotics
Antisecretory agents
Mucosal protectants
Antisecretory agents that enhance mucosal defenses
Antacids
What are differenced in treatment H. pylori induced and NSAID induced ulcers?
PUD Ulcers: 14-day, quadruple therapy
PPI + Bismuth + Metronidazole + Tetracycline
PPI + Amoxicillin + Metronidazole + Clarithromycin
NSAID Ulcers
- Identify an alternative for pain management or provide prophylaxis strategies
- Enteric-coated NSAIDs
- Take with meals
- Add misoprostol, or switching to a selective COX-2 inhibitor.
How is healing of ulcers monitored?
-Monitor for relief of pain.
-Radiologic or endoscopic examination of the ulcer site.
What level does gastric PH need to be to decrease Pepsin activity?
pH > 5
What are the 3 types of H. pylori testing?
Breath test
Serologic test
Stool test
What is the minimum number of antibiotics to treat PUD?
2
What are the drugs used to treat PUD?
Antibiotics
