Advanced Pharmacology –
Antimicrobial Review & Recall (TB,
HIV Coinfection, Malaria & Drug
Interactions)|Complete Verified
Questions Provided with A+ Graded
Rationales Latest Updated 2026
What is multidrug resistant TB?
A. Resistant to both Isoniazid (INH) and fluoroquinolones
B. Resistant to both rifampin and fluoroquinolones
C. Resistant to Pyrazinamide and ethambutol
D. Resistant to both Isoniazid (INH) and Rifampin
D. Resistant to both Isoniazid (INH) and Rifampin
What is extremely resistant TB resistant to?
A. One of the second line injectable second line drugs and all fluoroquinolones
B. All Fluoroquinolones ; Isoniazid [INH] and rifampin; and at least one of the injectable
second line drugs.
C. One of the second line injectable second line drugs and rifampin and INH
D. INH and rifampin, and all fluroroquinolones
B. All Fluoroquinolones ; Isoniazid [INH] and rifampin; and at least one of the injectable
second line drugs.
Which medications create problematic interactions with other HIV antiviral drugs?
A. Rifampin and Rifabutin
B. Rifampin and Amantadine
C. Rifampin and Isoniazid [INH]
D. Rifampin and Pyrazinamide (PZA)
A. Rifampin and Rifabutin
,Treating one infection interferes with treatment of the other in patients with both TB and HIV.
True or False
True
John has HIV and has just been diagnosed with TB. What is the minimum amount of time he
will need therapy?
A. 3 months
B. 6 months
C. 9 months
D. 1 year
B. 6 months
Which information should the nurse include when teaching a patient about INH therapy?
A. Tubercle bacilli cannot develop resistance to isoniazid during treatment.
B. Isoniazid is administered intravenously.
C. An adverse effect of isoniazid therapy is peripheral neuropathy, which can be reversed with
pyridoxine.
D. The dose of INH should be lowered if the patient is also taking phenytoin
C. An adverse effect of isoniazid therapy is peripheral neuropathy, which can be reversed with
pyridoxine.
A group of college students are traveling to a chloroquine-resistant malaria area for a mission
trip. Which of the following medications can be used for both prevention and treatment of
malaria in these students?
A. Pyrimethamine
B. Artemisinin
C. Atoraquone-proguanil
D. Melarsoprol
C. Atoraquone-proguanil
Which information should be included when teaching about rifampin?
A. Rifampin is safe to use in patients who have hepatic disease.
, B. Rifampin can change the color of body fluids to reddish orange.
C. Rifampin cannot be given IV.
D. Oral contraceptives are safe to use with rifampin therapy
B. Rifampin can change the color of body fluids to reddish orange.
Which TB medication can cause decrease in vision?
A. Ethambutol
B. Rifampin
C. Isoniazid (INH)
D. Pyrazinamide
A. Ethambutol
How do penicillins and cephalosporins work?
A. By inhibition of protein synthesis
B. By inhibiting bacterial protein synthesis
C. By weakening the cell wall and promoting lysis and death
D. By increasing permeability of cell membranes, increasing leakage of intracellular materials
C. By weakening the cell wall and promoting lysis and death
Bactericidal drugs:
A. are directly lethal to bacteria at achievable concentrations
B. are nonlethal to bacteria at achievable concentrations
C. can slow bacterial growth but do not cause death
D. are directly lethal to bacteria if minimum amount is given
A. are directly lethal to bacteria at achievable concentrations
Why are narrow spectrum antibiotics preferred over broad spectrum antibiotics?
A. Narrow spectrum antibiotics are more powerful
B. Broad spectrum antibiotics are weaker
C. Narrow spectrum antibiotics cover all gram negative bacteria
D. Broad spectrum antibiotics do the most to facilitate emergence of resistance
D. Broad spectrum antibiotics do the most to facilitate emergence of resistance
How does bacterial resistance develop with penicillins? Check all that apply.
Antimicrobial Review & Recall (TB,
HIV Coinfection, Malaria & Drug
Interactions)|Complete Verified
Questions Provided with A+ Graded
Rationales Latest Updated 2026
What is multidrug resistant TB?
A. Resistant to both Isoniazid (INH) and fluoroquinolones
B. Resistant to both rifampin and fluoroquinolones
C. Resistant to Pyrazinamide and ethambutol
D. Resistant to both Isoniazid (INH) and Rifampin
D. Resistant to both Isoniazid (INH) and Rifampin
What is extremely resistant TB resistant to?
A. One of the second line injectable second line drugs and all fluoroquinolones
B. All Fluoroquinolones ; Isoniazid [INH] and rifampin; and at least one of the injectable
second line drugs.
C. One of the second line injectable second line drugs and rifampin and INH
D. INH and rifampin, and all fluroroquinolones
B. All Fluoroquinolones ; Isoniazid [INH] and rifampin; and at least one of the injectable
second line drugs.
Which medications create problematic interactions with other HIV antiviral drugs?
A. Rifampin and Rifabutin
B. Rifampin and Amantadine
C. Rifampin and Isoniazid [INH]
D. Rifampin and Pyrazinamide (PZA)
A. Rifampin and Rifabutin
,Treating one infection interferes with treatment of the other in patients with both TB and HIV.
True or False
True
John has HIV and has just been diagnosed with TB. What is the minimum amount of time he
will need therapy?
A. 3 months
B. 6 months
C. 9 months
D. 1 year
B. 6 months
Which information should the nurse include when teaching a patient about INH therapy?
A. Tubercle bacilli cannot develop resistance to isoniazid during treatment.
B. Isoniazid is administered intravenously.
C. An adverse effect of isoniazid therapy is peripheral neuropathy, which can be reversed with
pyridoxine.
D. The dose of INH should be lowered if the patient is also taking phenytoin
C. An adverse effect of isoniazid therapy is peripheral neuropathy, which can be reversed with
pyridoxine.
A group of college students are traveling to a chloroquine-resistant malaria area for a mission
trip. Which of the following medications can be used for both prevention and treatment of
malaria in these students?
A. Pyrimethamine
B. Artemisinin
C. Atoraquone-proguanil
D. Melarsoprol
C. Atoraquone-proguanil
Which information should be included when teaching about rifampin?
A. Rifampin is safe to use in patients who have hepatic disease.
, B. Rifampin can change the color of body fluids to reddish orange.
C. Rifampin cannot be given IV.
D. Oral contraceptives are safe to use with rifampin therapy
B. Rifampin can change the color of body fluids to reddish orange.
Which TB medication can cause decrease in vision?
A. Ethambutol
B. Rifampin
C. Isoniazid (INH)
D. Pyrazinamide
A. Ethambutol
How do penicillins and cephalosporins work?
A. By inhibition of protein synthesis
B. By inhibiting bacterial protein synthesis
C. By weakening the cell wall and promoting lysis and death
D. By increasing permeability of cell membranes, increasing leakage of intracellular materials
C. By weakening the cell wall and promoting lysis and death
Bactericidal drugs:
A. are directly lethal to bacteria at achievable concentrations
B. are nonlethal to bacteria at achievable concentrations
C. can slow bacterial growth but do not cause death
D. are directly lethal to bacteria if minimum amount is given
A. are directly lethal to bacteria at achievable concentrations
Why are narrow spectrum antibiotics preferred over broad spectrum antibiotics?
A. Narrow spectrum antibiotics are more powerful
B. Broad spectrum antibiotics are weaker
C. Narrow spectrum antibiotics cover all gram negative bacteria
D. Broad spectrum antibiotics do the most to facilitate emergence of resistance
D. Broad spectrum antibiotics do the most to facilitate emergence of resistance
How does bacterial resistance develop with penicillins? Check all that apply.
