ESTUDYR
PSYCHOPHARMACOLOGY: ANTIPSYCHOTIC MEDICATIONS
1. Antipsychotic medications (neuroleptics) are classified into which two major categories?
A. Benzodiazepines and Mood Stabilizers
B. First-Generation (Typical) and Second-Generation (Atypical) Antipsychotics
C. SSRIs and SNRIs
D. MAOIs and TCAs
Answer: B
Rationale:
B is correct: Antipsychotics are divided into First-Generation (FGAs/Typical) and
Second-Generation (SGAs/Atypical).
A, C, and D are antidepressant or anxiolytic classes, not antipsychotics.
2. Which of the following are examples of FIRST-generation (Typical) antipsychotics? (Select
all that apply)
A. Haloperidol
B. Fluphenazine
C. Risperidone
D. Clozapine
E. Chlorpromazine
Answers: A, B, E
Rationale:
Haloperidol & Fluphenazine = high-potency FGAs
Chlorpromazine = low-potency FGA
Risperidone and Clozapine are SGAs.
3. Which conditions are approved indications for antipsychotic medications? (Select all that
apply)
A. Schizophrenia
B. Acute mania in bipolar disorder
, ESTUDYR
C. Generalized anxiety disorder
D. Adjunct treatment for major depressive disorder
E. Severe agitation and hyperactivity
Answers: A, B, D, E
Rationale:
Antipsychotics treat schizophrenia and bipolar disorder (mania/mixed states).
Some SGAs are approved as adjuncts in MDD.
Severe agitation is another indication.
GAD is primarily treated with SSRIs/SNRIs/benzodiazepines.
4. What is the primary mechanism of action (MOA) of FIRST-generation antipsychotics?
A. 5HT3 receptor antagonism
B. D2 dopamine receptor antagonism
C. GABA agonism
D. Norepinephrine reuptake inhibition
Answer: B
Rationale:
FGAs strongly block D2 receptors, especially in the mesolimbic pathway, reducing positive
symptoms of schizophrenia (hallucinations, delusions).
5. High-potency first-generation antipsychotics differ from low-potency agents because they:
A. Cause more sedation
B. Cause more anticholinergic effects
C. Have stronger D2 receptor antagonism and fewer effects at other receptors
D. Cause less extrapyramidal symptoms
Answer: C
Rationale:
High-potency = strong D2 blockade → ↑ EPS
Low-potency = more antihistaminic, antimuscarinic, and alpha-1 effects → sedation,
orthostasis, anticholinergic effects.
PSYCHOPHARMACOLOGY: ANTIPSYCHOTIC MEDICATIONS
1. Antipsychotic medications (neuroleptics) are classified into which two major categories?
A. Benzodiazepines and Mood Stabilizers
B. First-Generation (Typical) and Second-Generation (Atypical) Antipsychotics
C. SSRIs and SNRIs
D. MAOIs and TCAs
Answer: B
Rationale:
B is correct: Antipsychotics are divided into First-Generation (FGAs/Typical) and
Second-Generation (SGAs/Atypical).
A, C, and D are antidepressant or anxiolytic classes, not antipsychotics.
2. Which of the following are examples of FIRST-generation (Typical) antipsychotics? (Select
all that apply)
A. Haloperidol
B. Fluphenazine
C. Risperidone
D. Clozapine
E. Chlorpromazine
Answers: A, B, E
Rationale:
Haloperidol & Fluphenazine = high-potency FGAs
Chlorpromazine = low-potency FGA
Risperidone and Clozapine are SGAs.
3. Which conditions are approved indications for antipsychotic medications? (Select all that
apply)
A. Schizophrenia
B. Acute mania in bipolar disorder
, ESTUDYR
C. Generalized anxiety disorder
D. Adjunct treatment for major depressive disorder
E. Severe agitation and hyperactivity
Answers: A, B, D, E
Rationale:
Antipsychotics treat schizophrenia and bipolar disorder (mania/mixed states).
Some SGAs are approved as adjuncts in MDD.
Severe agitation is another indication.
GAD is primarily treated with SSRIs/SNRIs/benzodiazepines.
4. What is the primary mechanism of action (MOA) of FIRST-generation antipsychotics?
A. 5HT3 receptor antagonism
B. D2 dopamine receptor antagonism
C. GABA agonism
D. Norepinephrine reuptake inhibition
Answer: B
Rationale:
FGAs strongly block D2 receptors, especially in the mesolimbic pathway, reducing positive
symptoms of schizophrenia (hallucinations, delusions).
5. High-potency first-generation antipsychotics differ from low-potency agents because they:
A. Cause more sedation
B. Cause more anticholinergic effects
C. Have stronger D2 receptor antagonism and fewer effects at other receptors
D. Cause less extrapyramidal symptoms
Answer: C
Rationale:
High-potency = strong D2 blockade → ↑ EPS
Low-potency = more antihistaminic, antimuscarinic, and alpha-1 effects → sedation,
orthostasis, anticholinergic effects.
