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MI - CORRECT ANSWERS Death of myocardium from sudden blockage of coronary artery
blood flow
What causes cell death in MI? - CORRECT ANSWERS unstable plaque breaks off, triggering
platelet aggregation, coagulation cascade and thrombus formation. continued no blood flow in 10
seconds ischemia, 20 minutes cell die
What consequence of cell death leads to CP? - CORRECT ANSWERS hypoxia as cannot meet
cell demand for oxygen
How is MI diagnosed - CORRECT ANSWERS EKG (STEMI) or elevated Troponin (non-STEMI)
What might you find in blood consistent with MI? - CORRECT ANSWERS elevated CK MB,
Troponin
Where does CK MB and Troponin come from? - CORRECT ANSWERS Release of lysosomal
enzymes; CK MB detected after myocardial necrosis, Troponin released from damaged heart muscle
3 mechanism of cell injury related to reperfussion injury - CORRECT ANSWERS ischemia,
necrosis, reperfussion l/t RAS
define reperfussion injury - CORRECT ANSWERS injury that occurs after oxygen is
reintroduced to tissue perfusion
, how does inflammatory process contribute to reperfussion injury? - CORRECT ANSWERS as
oxygen is reintroduced it comes in contact with damaged proteins triggering inflammatory response
how does oxidative process contribute to RI? - CORRECT ANSWERS RAS causes impairment
of cell membrane and pro-apotptoic cells release. making cell unstable
what is primary Hypertension? - CORRECT ANSWERS Essential or idiopathic, elevated BP
without an identified cause, accounts for 90 - 95% of all cases of hypertension?
what is secondary hypertension? - CORRECT ANSWERS Elevated BP, labile BP; related to
conditions ie kidney dz; resistant to BP meds
what is significance of Ventricular hypertrophy and HTN? - CORRECT ANSWERS persistent
hypertension leads to ventricular hypertrophy; decrease CO
what comorbidities/conditions does HTN cause? - CORRECT ANSWERS stroke, ischemia,
heart failure, aneurysm, hemorrhage
what is preload? - CORRECT ANSWERS volume of blood in ventricles at end of diastole
what is afterload? - CORRECT ANSWERS peripheral resistance against which the left
ventricle must pump
hoe does HTN l/t CHF? - CORRECT ANSWERS overwork left ventricle due to increase
pressure; decreased pumping ability of heart and decreases CO.
identify pathological process of gangrene? - CORRECT ANSWERS form of coagulative
necrosis; interruption of blood flow l/t denaturing cells enzymes and bacterial invasion