LEHNE PHARMACOLOGY STRUCTURED
REVIEW SET FOR CHAPTERS 1 TO 110
FEATURING STUDY QUESTIONS AND
RATIONALE SUPPORT
©Pharmacology - The study of drugs and their interactions with living
systems
©Clinical Pharmacology - The study of drugs in humans
©Therapeutics - AKA "Pharmacotherapeutics"; The use of drugs to
diagnose, prevent or treat disease or to prevent pregnancy
©The BIG Three Characteristics any drug can have - 1) Effectiveness
2) Safety
3) Selectivity
©Effectiveness - Effective Drug= One that elicits responses for which
it's given
*Most important property for a drug to have
,©Safety - Safe Drug= One that can't produce harmful effects even
administered in very high doses for a long time.
*All drugs have the ability to cause injury, especially with high doses
and prolonged use
©Selectivity - Selective Drug= one that elicits only the response for
which it's given
There's no such thing as a wholly selective drug because all drugs cause
side effects
©Additional Properties of an 'Ideal Drug' - 1) Reversible Action
2) Predictability
3) Ease of Administration
4) Freedom from Drug Interactions
5) Low Cost
6) Chemical Stability
7) Possession of Simple Generic Names
©Factors that Determine the Intensity of Drug Responses -
ADMINISTRATION
-Med Errors
, - Patient Adherence
PHARMACOKINETICS
- Absorption
- Distribution
- Metabolism
- Excretion
*SOURCES OF INDIVIDUAL VARIATION
-Physiologic Variables
-Pathologic Variables
-Genetic Variables
PHARMACODYNAMICS
- Drug-receptor interactions
-Patients functional state
-Placebo effect
©Pharmacokinetics - The impact of the BODY on the drugs
Four Processes
1) Drug Absorption
2) Drug Distribution
3) Drug Metabolism
4) Drug Excretion
REVIEW SET FOR CHAPTERS 1 TO 110
FEATURING STUDY QUESTIONS AND
RATIONALE SUPPORT
©Pharmacology - The study of drugs and their interactions with living
systems
©Clinical Pharmacology - The study of drugs in humans
©Therapeutics - AKA "Pharmacotherapeutics"; The use of drugs to
diagnose, prevent or treat disease or to prevent pregnancy
©The BIG Three Characteristics any drug can have - 1) Effectiveness
2) Safety
3) Selectivity
©Effectiveness - Effective Drug= One that elicits responses for which
it's given
*Most important property for a drug to have
,©Safety - Safe Drug= One that can't produce harmful effects even
administered in very high doses for a long time.
*All drugs have the ability to cause injury, especially with high doses
and prolonged use
©Selectivity - Selective Drug= one that elicits only the response for
which it's given
There's no such thing as a wholly selective drug because all drugs cause
side effects
©Additional Properties of an 'Ideal Drug' - 1) Reversible Action
2) Predictability
3) Ease of Administration
4) Freedom from Drug Interactions
5) Low Cost
6) Chemical Stability
7) Possession of Simple Generic Names
©Factors that Determine the Intensity of Drug Responses -
ADMINISTRATION
-Med Errors
, - Patient Adherence
PHARMACOKINETICS
- Absorption
- Distribution
- Metabolism
- Excretion
*SOURCES OF INDIVIDUAL VARIATION
-Physiologic Variables
-Pathologic Variables
-Genetic Variables
PHARMACODYNAMICS
- Drug-receptor interactions
-Patients functional state
-Placebo effect
©Pharmacokinetics - The impact of the BODY on the drugs
Four Processes
1) Drug Absorption
2) Drug Distribution
3) Drug Metabolism
4) Drug Excretion
