LEHNE'S PHARMACOLOGY FOR NURSING
CARE 11TH EDITION 2026 COMPLETE EXAM
SCRIPT QUESTIONS AND VERIFIED SOLUTIONS
◉ Drugs that cause diabetes insipidus Answer: Lithium,
demeclocycline
◉ Drugs that cause fanconi syndrome Answer: Expired tetracycline
◉ Drugs that cause hemorrhagic cystitis Answer:
Cyclophosphamide, ifosfamide
◉ Drugs that cause interstitial nephritis Answer: Methicillin,
NSAIDs, furosemide
◉ Drugs that cause SIADH Answer: Carbamazepine,
Cyclophosphamide, SSRIs
◉ Drugs that cause dry cough Answer: ACE inhibitors
◉ Drugs that cause pulmonary fibrosis Answer: Bleomycin,
amiodarone, methotrexate, busulfan
,◉ Drugs that cause antimuscarinic reaction Answer: Atropine, TCAs,
H1-blockers, antipsychotics
◉ Drugs that cause disulfiram-like reaction Answer: Metronidazole,
certain cephalosporins, griseofulvin, procarbazine, 1st-generation
sulfonylureas
◉ Drugs that cause nephrotoxicity/ototoxicity Answer:
Aminoglycosides, vancomycin, loop diuretics, cisplatin. Cisplatin
toxicity may respond to amifostine.
◉ Cytochrome P-450 inducers Answer: Chronic alcohol use, St.
John's wort, Phenytoin Phenobarbital, Nevirapine, Rifampin,
Griseofulvin, Carbamazepine
◉ Cytochrome P-450 substrates Answer: Anti-epileptics,
Theophylline, Warfarin OCPs
◉ Cytochrome P-450 inhibitors Answer: Acute alcohol abuse,
Ritonavir, Amiodarone, Cimetidine, Ketoconazole, Sulfonamides,
Isoniazid (INH), Grapefruit juice, Quinidine, Macrolides, (except
azithromycin)
,◉ Sulfa drugs Answer: Probenecid, Furosemide, Acetazolamide,
Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine,
Sulfonylureas.
Patients with sulfa allergies may develop
fever, urinary tract infection, Stevens-
Johnson syndrome, hemolytic anemia, thrombocytopenia,
agranulocytosis, and urticaria (hives). Symptoms range from mild to
life threatening.
◉ -azole Answer: Ergosterol synthesis inhibitor
◉ -bendazole Answer: Antiparasitic/antihelmintic
◉ -cillin Answer: Peptidoglycan synthesis inhibitor
◉ -cycline Answer: Protein synthesis inhibitor
◉ -ivir Answer: Neuraminidase inhibitor
◉ -navir Answer: Protease inhibitor
◉ -ovir Answer: DNA polymerase inhibitor
, ◉ -thromycin Answer: Macrolide antibiotic
◉ -ane Answer: Inhalational general anesthetic
◉ -azine Answer: Typical antipsychotic
◉ -barbital Answer: Barbiturate
◉ -caine Answer: Local anesthetic
◉ -etine Answer: SSRI
◉ -ipramine, -triptyline Answer: TCA
◉ -triptan Answer: 5-HT1B/1D agonists
◉ -zepam, -zolam Answer: Benzodiazepine
◉ -chol Answer: Cholinergic agonist
◉ -curium, -curonium Answer: Nondepolarizing paralytic
CARE 11TH EDITION 2026 COMPLETE EXAM
SCRIPT QUESTIONS AND VERIFIED SOLUTIONS
◉ Drugs that cause diabetes insipidus Answer: Lithium,
demeclocycline
◉ Drugs that cause fanconi syndrome Answer: Expired tetracycline
◉ Drugs that cause hemorrhagic cystitis Answer:
Cyclophosphamide, ifosfamide
◉ Drugs that cause interstitial nephritis Answer: Methicillin,
NSAIDs, furosemide
◉ Drugs that cause SIADH Answer: Carbamazepine,
Cyclophosphamide, SSRIs
◉ Drugs that cause dry cough Answer: ACE inhibitors
◉ Drugs that cause pulmonary fibrosis Answer: Bleomycin,
amiodarone, methotrexate, busulfan
,◉ Drugs that cause antimuscarinic reaction Answer: Atropine, TCAs,
H1-blockers, antipsychotics
◉ Drugs that cause disulfiram-like reaction Answer: Metronidazole,
certain cephalosporins, griseofulvin, procarbazine, 1st-generation
sulfonylureas
◉ Drugs that cause nephrotoxicity/ototoxicity Answer:
Aminoglycosides, vancomycin, loop diuretics, cisplatin. Cisplatin
toxicity may respond to amifostine.
◉ Cytochrome P-450 inducers Answer: Chronic alcohol use, St.
John's wort, Phenytoin Phenobarbital, Nevirapine, Rifampin,
Griseofulvin, Carbamazepine
◉ Cytochrome P-450 substrates Answer: Anti-epileptics,
Theophylline, Warfarin OCPs
◉ Cytochrome P-450 inhibitors Answer: Acute alcohol abuse,
Ritonavir, Amiodarone, Cimetidine, Ketoconazole, Sulfonamides,
Isoniazid (INH), Grapefruit juice, Quinidine, Macrolides, (except
azithromycin)
,◉ Sulfa drugs Answer: Probenecid, Furosemide, Acetazolamide,
Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine,
Sulfonylureas.
Patients with sulfa allergies may develop
fever, urinary tract infection, Stevens-
Johnson syndrome, hemolytic anemia, thrombocytopenia,
agranulocytosis, and urticaria (hives). Symptoms range from mild to
life threatening.
◉ -azole Answer: Ergosterol synthesis inhibitor
◉ -bendazole Answer: Antiparasitic/antihelmintic
◉ -cillin Answer: Peptidoglycan synthesis inhibitor
◉ -cycline Answer: Protein synthesis inhibitor
◉ -ivir Answer: Neuraminidase inhibitor
◉ -navir Answer: Protease inhibitor
◉ -ovir Answer: DNA polymerase inhibitor
, ◉ -thromycin Answer: Macrolide antibiotic
◉ -ane Answer: Inhalational general anesthetic
◉ -azine Answer: Typical antipsychotic
◉ -barbital Answer: Barbiturate
◉ -caine Answer: Local anesthetic
◉ -etine Answer: SSRI
◉ -ipramine, -triptyline Answer: TCA
◉ -triptan Answer: 5-HT1B/1D agonists
◉ -zepam, -zolam Answer: Benzodiazepine
◉ -chol Answer: Cholinergic agonist
◉ -curium, -curonium Answer: Nondepolarizing paralytic
