Evolve Pharmacology hesi practice questions
and answers 2025\2026 A+ Grade
A client who has been taking phenazopyridine (Pyridium) for symptoms of urethritis and cystitis comes
to the clinic because her urine is reddish-orange. Which question should the practical nurse ask to
determine if the medication has been effective?
A) How much water have you been drinking each day?
B) Does the urine color stain your toilet bowl or undergarments?
C) Have you had any relief from urinary pain, burning, or urgency?
D) Did your urine appear cloudy or have a foul odor on voiding?
- correct answer C) Have you had any relief from urinary pain, burning, or urgency?
Feedback:
Phenazopyridine, an over-the-counter urinary analgesic, acts on the mucosa of the urinary tract to
relieve urinary pain, burning, itching, or urgency (C) associated with urethritis and cystitis. Although
determining if the client is forcing fluids (A), experiencing staining from Pyridium's side effect (B), or
having signs of a urinary infection (D) are worthwhile assessments, the therapeutic response of Pyridium
is related to urinary discomforts only.
A male client who has been receiving an antineoplastic drug has developed thrombocytopenia. What
instructions should the practical nurse (PN) reinforce?
A) Use suppository form of drugs.
B) Avoid large public gatherings.
C) Rise slowly when standing up.
D) Shave with an electric razor.
- correct answer D) Shave with an electric razor.
Feedback:
Thrombocytopenia is a common side effect of bone marrow depression caused by several antineoplastic
agents. The client is experiencing a low platelet count and should use an electric razor (D) to reduce his
risk of bleeding. (A, B, and C) are not indicated for a client who needs to implement thrombocytopenia
precautions.
,The practical nurse (PN) is caring for a client who has been taking prednisone (Deltasone) daily for a
year. Which adverse effect should the PN document in the client's record?
A) Photosensitvity.
B) Weight gain.
C) Loss of hair.
D) Pale skin color.
- correct answer B) Weight gain.
Feedback:
Long term use of prednisone causes fluid retention and redistribution of fat deposition. Weight gain (B)
and moon face reflect adverse effects of long-term prednisone use and should be documented. (A, C,
and D) do not occur with treatment using prednisone.
A female client with recurring headaches tells the practical nurse (PN) that she has been taking at least 4
grams of acetaminophen a day. Which laboratory studies should the PN review for this client?
A) Creatinine clearance.
B) Hepatic enzymes.
C) Coagulation values.
D) Arterial blood gases.
- correct answer B) Hepatic enzymes.
Feedback:
Liver toxicity can occur when doses of acetaminophen exceed 4 grams a day, resulting in an elevation in
hepatic enzyme values (B). (A, C, and D) do not reveal findings related to acetaminophen toxicity.
A client receives a prescription for an oral opioid analgesic for post-operative pain. Which adverse effect
should the practical nurse (PN) monitor for with the client?
A) Constipation.
B) Photosensitivity.
C) Decreased heart rate.
D) Frequent urination.
- correct answer A) Constipation.
Feedback:
, Opioid analgesics slow peristalsis, which leads to constipation (A), a common side effect of opiates. (B, C,
and D) are not associated with opioid analgesics.
Which action should the practical nurse implement when administering a buccal medication?
A) Encourage the client to swallow.
B) Administer water with medication.
C) Ensure the medication is positioned under the tongue.
D) Place the medication between the upper molar teeth and cheek.
- correct answer D) Place the medication between the upper molar teeth and cheek.
Feedback:
Buccal medications are placed between the upper molar teeth and the cheek (D) for absorption by the
capillaries of the oral mucosa. The client should be cautioned against swallowing, not (A). Buccal
medications are not administered with water (B). (C) describes sublingual administration.
What assessment is most important for the practical nurse (PN) to obtain prior to initiating medication
therapy with phenelzine (Nardil) for a client with depression?
A) Activity level.
B) Mood and affect.
C) Understanding of diet modification.
D) The client's support system.
- correct answer C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hypertensive crisis, a tyramine-free diet should be maintained during
antidepressant therapy with Nardil, a monoamine oxidase inhibitor (MAOI). It is most important to
determine if the client understands diet modification (C) before Nardil is initiated to prevent
consumption of foods that interact with Nardil. Although a client's activity level (A) and mood and affect
(B) should be monitored during antidepressant therapy, it is most important that the client understand
diet modifications. The client's support system (D) and network of family and friends is important, but
the client should understand the responsibility of dietary compliance with the medication regimen.
The practical nurse (PN) is unable to arouse a client who is receiving meperidine (Demerol) for
postoperative pain. The client is stuporous, has constricted pupils, and a respiratory rate of 8
breaths/minute. Which PRN prescription should the PN give the client?
A) Naloxone (Narcan).
and answers 2025\2026 A+ Grade
A client who has been taking phenazopyridine (Pyridium) for symptoms of urethritis and cystitis comes
to the clinic because her urine is reddish-orange. Which question should the practical nurse ask to
determine if the medication has been effective?
A) How much water have you been drinking each day?
B) Does the urine color stain your toilet bowl or undergarments?
C) Have you had any relief from urinary pain, burning, or urgency?
D) Did your urine appear cloudy or have a foul odor on voiding?
- correct answer C) Have you had any relief from urinary pain, burning, or urgency?
Feedback:
Phenazopyridine, an over-the-counter urinary analgesic, acts on the mucosa of the urinary tract to
relieve urinary pain, burning, itching, or urgency (C) associated with urethritis and cystitis. Although
determining if the client is forcing fluids (A), experiencing staining from Pyridium's side effect (B), or
having signs of a urinary infection (D) are worthwhile assessments, the therapeutic response of Pyridium
is related to urinary discomforts only.
A male client who has been receiving an antineoplastic drug has developed thrombocytopenia. What
instructions should the practical nurse (PN) reinforce?
A) Use suppository form of drugs.
B) Avoid large public gatherings.
C) Rise slowly when standing up.
D) Shave with an electric razor.
- correct answer D) Shave with an electric razor.
Feedback:
Thrombocytopenia is a common side effect of bone marrow depression caused by several antineoplastic
agents. The client is experiencing a low platelet count and should use an electric razor (D) to reduce his
risk of bleeding. (A, B, and C) are not indicated for a client who needs to implement thrombocytopenia
precautions.
,The practical nurse (PN) is caring for a client who has been taking prednisone (Deltasone) daily for a
year. Which adverse effect should the PN document in the client's record?
A) Photosensitvity.
B) Weight gain.
C) Loss of hair.
D) Pale skin color.
- correct answer B) Weight gain.
Feedback:
Long term use of prednisone causes fluid retention and redistribution of fat deposition. Weight gain (B)
and moon face reflect adverse effects of long-term prednisone use and should be documented. (A, C,
and D) do not occur with treatment using prednisone.
A female client with recurring headaches tells the practical nurse (PN) that she has been taking at least 4
grams of acetaminophen a day. Which laboratory studies should the PN review for this client?
A) Creatinine clearance.
B) Hepatic enzymes.
C) Coagulation values.
D) Arterial blood gases.
- correct answer B) Hepatic enzymes.
Feedback:
Liver toxicity can occur when doses of acetaminophen exceed 4 grams a day, resulting in an elevation in
hepatic enzyme values (B). (A, C, and D) do not reveal findings related to acetaminophen toxicity.
A client receives a prescription for an oral opioid analgesic for post-operative pain. Which adverse effect
should the practical nurse (PN) monitor for with the client?
A) Constipation.
B) Photosensitivity.
C) Decreased heart rate.
D) Frequent urination.
- correct answer A) Constipation.
Feedback:
, Opioid analgesics slow peristalsis, which leads to constipation (A), a common side effect of opiates. (B, C,
and D) are not associated with opioid analgesics.
Which action should the practical nurse implement when administering a buccal medication?
A) Encourage the client to swallow.
B) Administer water with medication.
C) Ensure the medication is positioned under the tongue.
D) Place the medication between the upper molar teeth and cheek.
- correct answer D) Place the medication between the upper molar teeth and cheek.
Feedback:
Buccal medications are placed between the upper molar teeth and the cheek (D) for absorption by the
capillaries of the oral mucosa. The client should be cautioned against swallowing, not (A). Buccal
medications are not administered with water (B). (C) describes sublingual administration.
What assessment is most important for the practical nurse (PN) to obtain prior to initiating medication
therapy with phenelzine (Nardil) for a client with depression?
A) Activity level.
B) Mood and affect.
C) Understanding of diet modification.
D) The client's support system.
- correct answer C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hypertensive crisis, a tyramine-free diet should be maintained during
antidepressant therapy with Nardil, a monoamine oxidase inhibitor (MAOI). It is most important to
determine if the client understands diet modification (C) before Nardil is initiated to prevent
consumption of foods that interact with Nardil. Although a client's activity level (A) and mood and affect
(B) should be monitored during antidepressant therapy, it is most important that the client understand
diet modifications. The client's support system (D) and network of family and friends is important, but
the client should understand the responsibility of dietary compliance with the medication regimen.
The practical nurse (PN) is unable to arouse a client who is receiving meperidine (Demerol) for
postoperative pain. The client is stuporous, has constricted pupils, and a respiratory rate of 8
breaths/minute. Which PRN prescription should the PN give the client?
A) Naloxone (Narcan).
