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Describe the possible effect of genetic disorders: Ans✓✓✓can damage
and mutate DNA, resulting in the initiation of events that can cause cell
injury. Damaged DNA is transcribed as defective RNA, which transmits
flawed instructions to the ribosomes. At the ribosomees, the defective
RNA causes synthesis of abnormal cellular proteins, which can initiate
disease.
Describe the impact that cellular injury often has: Ans✓✓✓injury to
DNA can cause mutations which change in cell structure and function.
Commonly changes in the cell's DNA will initiate changes that bring
about genetically programmed cell degeneration, also called the
apoptosis.
Gene mutations Ans✓✓✓occur when a gene is DAMAGED or
CHANGED in such a way that it alters the genetic code carried by the
gene.
change of nucleotides (deletions or insertion)
causes of gene mutations: Ans✓✓✓can be INHERITED from parents
or can occur spontaneously because of ENVIRONMENTAL influences.
,Describe the consequence of mutations to gamete genes:
Ans✓✓✓known as germ cell mutations, can be passed down to future
offspring.
four diseases that are the result of multifactorial genetic influences:
Ans✓✓✓Hypertension, heart disease, diabetes mellitus (DM), and
most cancers are caused by a combination genetics and environment or
a combination of several defective genes working, or not working
together.
multiple factors that contribute to disease development Ans✓✓✓an
individual INHERITS one or more gene defects that predisposes them to
the disorder, and then ENVIRONMENTAL or BEHAVIORS triggers
such as diet, exposure to toxins, or sedentary lifestyle contribute to
disease development.
"Two Hit" hypothesis Ans✓✓✓
what happens in most cases when one of a pair's alleles becomes
damaged or mutated: Ans✓✓✓normal corresponding allele can
counteract the effect.
In many diseases both alleles have to be mutated.
components that should be included in a genetic risk assessment:
Ans✓✓✓include a family history with multigenerational patterns of
illness, as well as ethnic, cultural, and social practices.
, Discuss the importance of including ethnicity in a genetic assessment:
Ans✓✓✓certain illness patterns are seen in specific ethnic groups.
Eustress Ans✓✓✓A positive stress that energizes a person and helps a
person reach a goal
physical responses that occur with any type of stress: Ans✓✓✓excites
the nervous, endocrine, and musculoskeletal systems and allows one to
quickly react to an emergent situation.
The heart rate speeds up and myocardial contractile function
strengthens; the bronchioles dilate, allowing more air to enter the lungs.
Chemical mediators provoke stress hormones that are released into the
bloodstream, priming the body to be alert, Concentration becomes more
focused, reaction time is faster, and strength and agility increase.
What happens when the stressful situation ends? Ans✓✓✓Hormonal
signals switch off the stress response and the body returns to normal.
Describe the effects of frequent or long term stressors: Ans✓✓✓can
have a hazardous effect on the body, diminishing immunity and
increasing the risk of autoimmune disease, cancer, heart disease
depression and a variety of other illnesses.
Selye's Stress Response Theory Ans✓✓✓