Neuropharmacology - Advanced
Pharm - NURS8024 - Exam Three
In Parkinson's disease the amount of __________ lost directly correlates to severity of
symptoms. - Correct Answers -Dopamine
The goal of treatment for Parkinson's disease is to CURE and REVERSE degeneration.
T / F - Correct Answers -False - Tx focus is on restoring balance
Sinamet (Levodopa & Carbidopa) MOA includes: - Correct Answers -Assist in
conversion of levodopa to dopamine in the basal nigra - Increase in body's production of
dopamine
How does Carbidopa help in Parkinson's disease? - Correct Answers -Carbidopa
enhances availability of levodopa to cross the BBB. Decrease metabolism of levodopa
in the GI system
An NP understand that treatment effectiveness _____________ between the 3rd and
5th year of Parkinson treatment using sinemet. - Correct Answers -Decreases
Important Pt Ed on Levodopa: - Correct Answers -Take on an Empty Stomach
ADE with Levodopa include: - Correct Answers -CNS effects (Visual/Auditory
Hallucinations, AIM, depression, GI effects, Tachy, Acute glaucoma
Amantadine is used to treat? - Correct Answers -MINOR Parkinsons
MOA for Amantadine includes: - Correct Answers -Enhances dopaminergic
neurotransmission, muscarininc blocking
An NP would be cautious in prescribing Amantadine for minor Parkinson's in a patient
with what dx? - Correct Answers -Seizure D/O & CHF
Name two dopamine receptor agonists: - Correct Answers -Ropinirole & Pramipexole
Name the one anticholingeric for EPS / Parkinsons - Correct Answers -Cogentin /
Benzotropine
, ADE of dopamine receptor agonists include: - Correct Answers -GI, Postural HYPO,
Dyskinesias, confusion, delusions, hallucinations, IMPULSIVITY
Ropinirole and Pramipexole CAUSE: - Correct Answers -IMPULSIVITY
Cogentin / Benzotropine is an________________ drug - Correct Answers -
Anticholinergic
MAO-B Inbhitors - Correct Answers -Monamine Oxidase B Inhibitors
When prescribing MAO-B Inhibitors use CAUTION with what two medications? - Correct
Answers -Fluoxetine or Meperidine (Prozac or Demerol)
MAO-B Inhibitors include: - Correct Answers -Selegiline (Eldepryl) & Rasagiline (Azilect)
Use MAO-B Inhibitors _____________ and adjunct with __________. - Correct
Answers -Early ; Levodopa
COMT (Catehcol-O-Methyltransferase Inhibitors) - Correct Answers -Help with uptake of
Levodopa which increases dopamine in CNS
CAUTION when using _______________ & ___________ as both are major enzymes
that metabolize catecholamines. - Correct Answers -MAO-B and COMT
Anticholinergics in Parkinson's disease are prescribed because........ - Correct Answers
-Decrease Tremors
Decrease Rigidity
Decrease Drooling
An experienced NP would know what about medication to treat Alzheimers disease? -
Correct Answers -Drugs are palliative - Provides only modest ST benefits - FATAL
Name the three types of Alzheimers Disease: - Correct Answers -Accumulation of
Senile Plaques (Beta-Amyloid)
Formation of numerous neurofibrillary tangles
Loss of Cortical Neurons - Especially Cholinergic neurons
After PCP consult which medication can be started for EARLY Alzheimers Disease? -
Correct Answers -Donepezil (Aricept or EARLYCEPT), Rivastigmine (Exelon),
Galantamine (Razadyne)
Pharm - NURS8024 - Exam Three
In Parkinson's disease the amount of __________ lost directly correlates to severity of
symptoms. - Correct Answers -Dopamine
The goal of treatment for Parkinson's disease is to CURE and REVERSE degeneration.
T / F - Correct Answers -False - Tx focus is on restoring balance
Sinamet (Levodopa & Carbidopa) MOA includes: - Correct Answers -Assist in
conversion of levodopa to dopamine in the basal nigra - Increase in body's production of
dopamine
How does Carbidopa help in Parkinson's disease? - Correct Answers -Carbidopa
enhances availability of levodopa to cross the BBB. Decrease metabolism of levodopa
in the GI system
An NP understand that treatment effectiveness _____________ between the 3rd and
5th year of Parkinson treatment using sinemet. - Correct Answers -Decreases
Important Pt Ed on Levodopa: - Correct Answers -Take on an Empty Stomach
ADE with Levodopa include: - Correct Answers -CNS effects (Visual/Auditory
Hallucinations, AIM, depression, GI effects, Tachy, Acute glaucoma
Amantadine is used to treat? - Correct Answers -MINOR Parkinsons
MOA for Amantadine includes: - Correct Answers -Enhances dopaminergic
neurotransmission, muscarininc blocking
An NP would be cautious in prescribing Amantadine for minor Parkinson's in a patient
with what dx? - Correct Answers -Seizure D/O & CHF
Name two dopamine receptor agonists: - Correct Answers -Ropinirole & Pramipexole
Name the one anticholingeric for EPS / Parkinsons - Correct Answers -Cogentin /
Benzotropine
, ADE of dopamine receptor agonists include: - Correct Answers -GI, Postural HYPO,
Dyskinesias, confusion, delusions, hallucinations, IMPULSIVITY
Ropinirole and Pramipexole CAUSE: - Correct Answers -IMPULSIVITY
Cogentin / Benzotropine is an________________ drug - Correct Answers -
Anticholinergic
MAO-B Inbhitors - Correct Answers -Monamine Oxidase B Inhibitors
When prescribing MAO-B Inhibitors use CAUTION with what two medications? - Correct
Answers -Fluoxetine or Meperidine (Prozac or Demerol)
MAO-B Inhibitors include: - Correct Answers -Selegiline (Eldepryl) & Rasagiline (Azilect)
Use MAO-B Inhibitors _____________ and adjunct with __________. - Correct
Answers -Early ; Levodopa
COMT (Catehcol-O-Methyltransferase Inhibitors) - Correct Answers -Help with uptake of
Levodopa which increases dopamine in CNS
CAUTION when using _______________ & ___________ as both are major enzymes
that metabolize catecholamines. - Correct Answers -MAO-B and COMT
Anticholinergics in Parkinson's disease are prescribed because........ - Correct Answers
-Decrease Tremors
Decrease Rigidity
Decrease Drooling
An experienced NP would know what about medication to treat Alzheimers disease? -
Correct Answers -Drugs are palliative - Provides only modest ST benefits - FATAL
Name the three types of Alzheimers Disease: - Correct Answers -Accumulation of
Senile Plaques (Beta-Amyloid)
Formation of numerous neurofibrillary tangles
Loss of Cortical Neurons - Especially Cholinergic neurons
After PCP consult which medication can be started for EARLY Alzheimers Disease? -
Correct Answers -Donepezil (Aricept or EARLYCEPT), Rivastigmine (Exelon),
Galantamine (Razadyne)
