NGR 6172 - PHARM EXAM 3 STUDY GUIDE.

NGR 6172 - PHARM EXAM 3 STUDY GUIDE/NGR 6172 - PHARM EXAM 3 STUDY GUIDE. CHAPTER 22 ● HTN first line therapy: diuretics and calcium channel blockers - diuretics: decrease plasma and extracellular fluid volumes. Results = decrease preload, decrease CO, decrease total peripheral resistance. Overall effect: decrease workload of hear and decrease BP. Thiazide is most commonly used - calcium channel blockers: smooth muscle relaxation by blocking binding of calcium to receptors and preventing muscle contraction. Results = decrease peripheral smooth muscle tone, decrease SVR, decrease BP. Amlodipine is most commonly used. - ACE inhibitor for HF and hypertension ● BP regulation - cardiac factors: heart rate and contractibility � beta blockers, calcium channel blockers, centrally acting adrenergic - circulating volume: salt and aldosterone � ACE inhibitors, diuretics