Comprehensive Nephrology Exam Guide:
Pre-Renal, Intrinsic, Post-Renal AKI,
Urine Sediment Analysis, FENa
Interpretation, ATN, AIN, Nephrotic
Syndrome, Emergent Dialysis
Indications, and Glomerular Disorders
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Rationales Latest Updated 2026
Pre-Renal
What is the nephrologic condition:
Specific Gravity- high
Dipstick blood- negative
Dipstick protein- negative
Urine Sediment- negative, hyaline casts
Vasculitis or Glomerulonephritis
What is the nephrologic condition:
Specific Gravity- normal/high
Dipstick blood- positive
Dipstick protein- positive
Urine Sediment- RBC cases, dysmorphic RBCs
Acute Tubular Necrosis
What is the nephrologic condition:
Specific Gravity- Isosmotic
Dipstick blood- +/-
Dipstick protein- negative
Urine Sediment- Granular casts, RTECs
Acute Interstitial Nephritis
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What is the nephrologic condition:
Specific Gravity- Isosmotic
Dipstick blood- +/-
Dipstick protein- +/-
Urine Sediment- WBC casts, eosinophils
Post-Renal
What is the nephrologic condition:
Specific Gravity- Isosmotic
Dipstick blood- negative
Dipstick protein- negative
Urine Sediment- negative, sometimes WBCs/RBCs
Pre-Renal
Pre, Post, or Intrinsic Renal Disorder?
BUN/Cr: >20
Specific Gravity: ?1.02
Urine Osm: >350
Urine Na: <20
FeNa: <1
Ucreat/Pcreat: >40
Intrinsic
Pre, Post, or Intrinsic Renal Disorder?
BUN/Cr: 10-20
Specific Gravity: 1.010
Urine Osm: 300
Urine Na: >30
FeNa: >2
Ucreat/Pcreat: <20
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Post-Renal
Pre, Post, or Intrinsic Renal Disorder?
BUN/Cr: 10-20
Specific Gravity: >1.010
Urine Osm: <400
Urine Na: <20
FeNa: >3
Ucreat/Pcreat: <20
Pre-Renal AKI
- result of a decrease in renal blood flow and perfusion of the kidney
-most common cause of AKI in outpatient setting
Pre-Renal
______________ AKI etiology:
-hypovolemia- vomiting, diarrhea, diuretics, etc
-decreased cardiac output- MI/CHF
-systemic vasodilation- sepsis, cirrhosis, anesthesia
-atherosclerosis, fibromuscular dysplasia, medications that impair glomerular blood flow
Intrinsic AKI
-result of disease affecting one of the renal parenchymal compartments
-most common cause of inpatient renal failure
-kidneys unable to concentrace urine and reabsorb Na, H2O and urea
Intrinsic
______________ AKI etiology:
-Tubules: sepsis, ischemia, toxins like radiocontrast
-Interstitium: allergic drug rxn, eosinophils
-Glomeruli
-Vascular
Post-Renal AKI
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