MEDS 581 Final Review - Lecture 19 UPDATED ACTUAL
Questions and CORRECT Answers
Measles -Caused by rubeola virus
-Highly transmissible
-~2.6M worldwide deaths before vaccination
-Illness common in kids
-Vax introduced in 1963
-Belongs to Morbillivirus
-Humans only natural host
Spread/Pathogenesis -Droplet/Airborne transmission
-Inhale droplet
-Virus replicates in lymphoid tissue in URT
-Progeny invade epithelial cells and enter airways propagating spread
-Enters/Infects entire resp. tract
-Accounts for cough and coryza
-Lead to secondary pneumonias
R0 Expected number of secondary cases produced by single infection in susceptible
population
T or F: R0 = τ · c ̄ · d True
T or F: R0 = τ · c ̄ · d is a measure of how infectious a new True
disease is and helps guide epidemic control strategies
implemented by gov't and health organizations
Basic Assumptions -If <1, disease dies out
-If >1, disease spreads
T or F: Goal for disease containment is R0 > 1 False - R0 < 1
SIR Epidemic Model -Susceptible-Infected-Removed model
-Constant/Closed pop size
-Constant rates
-No demography
-Well-mixed pop
Measles - Clinical Presentation -Acute febrile illness
-Classic Koplik spots before rash
-Measles rash coincides temporarily w/ appearance of serum antibody and
termination of communicability of disease
Questions and CORRECT Answers
Measles -Caused by rubeola virus
-Highly transmissible
-~2.6M worldwide deaths before vaccination
-Illness common in kids
-Vax introduced in 1963
-Belongs to Morbillivirus
-Humans only natural host
Spread/Pathogenesis -Droplet/Airborne transmission
-Inhale droplet
-Virus replicates in lymphoid tissue in URT
-Progeny invade epithelial cells and enter airways propagating spread
-Enters/Infects entire resp. tract
-Accounts for cough and coryza
-Lead to secondary pneumonias
R0 Expected number of secondary cases produced by single infection in susceptible
population
T or F: R0 = τ · c ̄ · d True
T or F: R0 = τ · c ̄ · d is a measure of how infectious a new True
disease is and helps guide epidemic control strategies
implemented by gov't and health organizations
Basic Assumptions -If <1, disease dies out
-If >1, disease spreads
T or F: Goal for disease containment is R0 > 1 False - R0 < 1
SIR Epidemic Model -Susceptible-Infected-Removed model
-Constant/Closed pop size
-Constant rates
-No demography
-Well-mixed pop
Measles - Clinical Presentation -Acute febrile illness
-Classic Koplik spots before rash
-Measles rash coincides temporarily w/ appearance of serum antibody and
termination of communicability of disease
