Ultimate USMLE Step 1 Mega Review:
High-Yield Pathology, Genetics,
Microbiology, Pharmacology, Neuro &
Endocrine – Complete Rapid Recall
Verified Questions Provided with A+
Graded Rationales Latest Updated 2026
Cerebral Vascular Accident
Migraines put you at an increased risk for what?
S2
the sacral attachment that allows for craniosacral motion?
CN III, IV, V1, V2, V3, VI
Cranial nerves in the Cavernous Sinus
Subfalcine Herniation
brain herniation that can cause mental status changes and reappearance of primitive
neurological reflexes
Legionella pneumophila
gram negative rod that stains poorly and is found in water sources
Williams Syndrome
-elfin facies (wide mouth, short nose, long philtrum
-talks excessively
-hyperetensible joints
-deletion in long arm of chrom 7
Haemophilus Influenzae b
-gram negative coccobacilli
-grows on chocolate agar
-encapsulated
Patau Syndrome
1|Page
,-trisomy 13
-defect in fusion of prechordal mesoderm
-micro/holoproencephaly, cleft palate, puched out lesion on skull
-umbilical hernia/omphalocele
-rocker bottom feet
LH and testosterone
hormones secreted by leydig cells
Inhibin B and FSH
hormones secreted by sertoli cells
Glucagonoma
-assoc with pancreatic alpha cells
-hyperglycemia, polyuria, increased thirst, weight loss
-necrolytic migratory erythema (blistering, crusts, scaling around mouth)
-tachycardia
-assoc with MEN1
Alzheimers
-amyloid plaques
-neurofibrillary tangles in cerebral cortex
Tetrology of Fallot
-RVOT obstruction
-Vent septal defect
-Overriding aorta
-concentric RVH
Cavernous hemangioma
most common benign liver tumor
Arterial Claudication
-leg pain with exercise
-assoc with atherosclerosis
-imbalance between blood supply demand
-peripheral artery disease
Phosphodiesteriase inhibitor (e.g. clostazol)
2|Page
,what do you give for arterial claudication?
BCL2
gene assoc with follicular lymphoma
BRAF
gene assoc with hairy cell leukemia and melanoma
MYC; t(8;14)
gene and translocation assoc with Burkitts lymphoma
13 q deletion
gene alteration assoc with CLL
PML/RARA; t(15;17)
gene and translocation assoc with AML
t(9;22)
translocation assoc with CML
CAG
trinucleotide repeat assoc with Huntingtons
CGG
trinucleotide repeat assoc with fragile X
GAA
trinucleotide repeat assoc with Friedrich's Ataxia
CTG
trinucleotide repeat assoc with myotonic dystrophy
MEN 1
-parathyroid adenomas
-pancreatic neuroendocrine tumors
-pituitary adenomas
MEN 2a
3|Page
, -Chromosome 10
-medullary thyroid carcinoma
-pheochromocytoma
-parathyroid adenomas
MEN 2B
-Chromosome 10
-Medullary Thyroid carcinoma
-Pheochromocytoma
MEN 4
-Chromosome 12
-Parathyroid adenoma
-Pituitary adenoma
-Testicular/Ovarian Cancer
-Renal/Adrenal tumor
Epinephrine, Norepinephrine, Dopamine
What secreted from the adrenal medulla?
Androgens
What is secreted from the Zona Reticularis?
Cortisol
What is secreted from the Zona Fasciculata?
Aldosterone
What is secreted from the Zona Glomerulosa?
Korsakoff Syndrome
-chronic thiamine deficiency (alcoholism)
-anterograde and retrograde amnesia
-Confuabulation (making up false memories)
Roseola (HHV-6)
-3 day fever
-macular rash that starts on trunk and can spread to extremities and face
-in children that have had their vaccinations
4|Page
High-Yield Pathology, Genetics,
Microbiology, Pharmacology, Neuro &
Endocrine – Complete Rapid Recall
Verified Questions Provided with A+
Graded Rationales Latest Updated 2026
Cerebral Vascular Accident
Migraines put you at an increased risk for what?
S2
the sacral attachment that allows for craniosacral motion?
CN III, IV, V1, V2, V3, VI
Cranial nerves in the Cavernous Sinus
Subfalcine Herniation
brain herniation that can cause mental status changes and reappearance of primitive
neurological reflexes
Legionella pneumophila
gram negative rod that stains poorly and is found in water sources
Williams Syndrome
-elfin facies (wide mouth, short nose, long philtrum
-talks excessively
-hyperetensible joints
-deletion in long arm of chrom 7
Haemophilus Influenzae b
-gram negative coccobacilli
-grows on chocolate agar
-encapsulated
Patau Syndrome
1|Page
,-trisomy 13
-defect in fusion of prechordal mesoderm
-micro/holoproencephaly, cleft palate, puched out lesion on skull
-umbilical hernia/omphalocele
-rocker bottom feet
LH and testosterone
hormones secreted by leydig cells
Inhibin B and FSH
hormones secreted by sertoli cells
Glucagonoma
-assoc with pancreatic alpha cells
-hyperglycemia, polyuria, increased thirst, weight loss
-necrolytic migratory erythema (blistering, crusts, scaling around mouth)
-tachycardia
-assoc with MEN1
Alzheimers
-amyloid plaques
-neurofibrillary tangles in cerebral cortex
Tetrology of Fallot
-RVOT obstruction
-Vent septal defect
-Overriding aorta
-concentric RVH
Cavernous hemangioma
most common benign liver tumor
Arterial Claudication
-leg pain with exercise
-assoc with atherosclerosis
-imbalance between blood supply demand
-peripheral artery disease
Phosphodiesteriase inhibitor (e.g. clostazol)
2|Page
,what do you give for arterial claudication?
BCL2
gene assoc with follicular lymphoma
BRAF
gene assoc with hairy cell leukemia and melanoma
MYC; t(8;14)
gene and translocation assoc with Burkitts lymphoma
13 q deletion
gene alteration assoc with CLL
PML/RARA; t(15;17)
gene and translocation assoc with AML
t(9;22)
translocation assoc with CML
CAG
trinucleotide repeat assoc with Huntingtons
CGG
trinucleotide repeat assoc with fragile X
GAA
trinucleotide repeat assoc with Friedrich's Ataxia
CTG
trinucleotide repeat assoc with myotonic dystrophy
MEN 1
-parathyroid adenomas
-pancreatic neuroendocrine tumors
-pituitary adenomas
MEN 2a
3|Page
, -Chromosome 10
-medullary thyroid carcinoma
-pheochromocytoma
-parathyroid adenomas
MEN 2B
-Chromosome 10
-Medullary Thyroid carcinoma
-Pheochromocytoma
MEN 4
-Chromosome 12
-Parathyroid adenoma
-Pituitary adenoma
-Testicular/Ovarian Cancer
-Renal/Adrenal tumor
Epinephrine, Norepinephrine, Dopamine
What secreted from the adrenal medulla?
Androgens
What is secreted from the Zona Reticularis?
Cortisol
What is secreted from the Zona Fasciculata?
Aldosterone
What is secreted from the Zona Glomerulosa?
Korsakoff Syndrome
-chronic thiamine deficiency (alcoholism)
-anterograde and retrograde amnesia
-Confuabulation (making up false memories)
Roseola (HHV-6)
-3 day fever
-macular rash that starts on trunk and can spread to extremities and face
-in children that have had their vaccinations
4|Page
