AtroPen (atropine):
- Actions/Uses
- Occupies muscarinic receptors
- Atropine blocks the parasympathetic actions of ACh and
induces symptoms of the fight-or-flight response, such as:
*Increased heart rate
*Bronchodilation
*Decreased motility in the gastrointestinal (GI) tract
*Mydriasis
*Decreased secretions from glands
- Atropine may be used to:
*Treat hypermotility diseases of the gastrointestinal (GI)
tract such as irritable bowel syndrome (IBS)
*Suppress secretions during surgical procedures
*Increase the heart rate in patients with bradycardia
*Dilate the pupil during eye examinations
- Atropine therapy is useful for the treatment of:
*Reflexive bradycardia in infants
*Infantile hypertrophic pyloric stenosis
AtroPen (atropine):
,- Adverse Effects
- The side effects of atropine limit its therapeutic usefulness and
are predictable extensions of its autonomic function
- Side effects:
*Dry mouth
*Constipation
*Urinary retention
*Increased heart rate
- Initial CNS excitement may progress to delirium and even
coma
AtroPen (atropine):
- Contraindications
- Glaucoma
*AtroPen (atropine) may increase pressure within the eye
- Obstructive disorders of the gastrointestinal (GI) tract
- Paralytic ileus
- Bladder neck obstruction
- Benign prostatic hyperplasia
- Myasthenia gravis
- Cardiac insufficiency
- Acute hemorrhage
What are therapeutic uses of anticholinergics?
, - GI disorders:
*Decreasing the secretion of gastric acid in peptic ulcer disease
*Slowing intestinal motility
*Reducing the cramping and diarrhea associated with irritable
bowel syndrome (IBS)
- Ophthalmic procedures:
*Anticholinergics may be used to cause mydriasis or cycloplegia
during eye procedures
- Cardiac rhythm abnormalities:
*Accelerating the heart rate in patients experiencing bradycardia
- Anesthesia adjuncts:
*Decreasing excessive respiratory secretions
*Reversing bradycardia caused by general anesthesia
- Asthma/COPD
- Overactive bladder (urge incontinence)
- Parkinson's disease
What is Transderm-Scop (scopolamine) used for?
- Produce sedation
- Prevent motion sickness
What are the different natural catecholamines?