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Which of the following is a hallmark symptom of GERD?
A. Hematemesis
B. Heartburn
C. Constipation
D. Right upper quadrant pain
Correct Answer: B. Heartburn
Rationale: GERD is characterized by acid reflux causing a burning sensation in the chest,
especially after meals or when lying down.
What is the most common cause of small bowel obstruction in adults?
A. Hernia
B. Tumor
C. Adhesions
D. Volvulus
Correct Answer: C. Adhesions
Rationale: Post-surgical adhesions are the leading cause of small bowel obstruction in
developed countries.
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,Which bacterium is most commonly associated with peptic ulcer disease?
A. Escherichia coli
B. Helicobacter pylori
C. Clostridium difficile
D. Streptococcus pyogenes
Correct Answer: B. Helicobacter pylori
Rationale: H. pylori disrupts the mucosal barrier, leading to ulcer formation in the stomach
and duodenum.
Which of the following is a distinguishing feature of Crohn’s disease compared to ulcerative
colitis?
A. Continuous inflammation
B. Involvement of only the colon
C. Transmural inflammation
D. Presence of pseudopolyps
Correct Answer: C. Transmural inflammation
Rationale: Crohn’s disease affects the full thickness of the bowel wall and can occur anywhere
in the GI tract with skip lesions
A patient with liver cirrhosis presents with confusion and asterixis. What is the most likely
cause?
A. Hypoglycemia
B. Hepatic encephalopathy
C. Stroke
D. Hyponatremia
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,Correct Answer: B. Hepatic encephalopathy
Rationale: Accumulation of ammonia due to impaired liver detoxification leads to
neuropsychiatric symptoms like confusion and flapping tremor (asterixis).
Which neurotransmitter is most closely associated with the pathophysiology of depression?
A. Acetylcholine
B. GABA
C. Serotonin
D. Glutamate
Correct Answer: C. Serotonin
Rationale: Serotonin deficiency is a key factor in the development of depressive symptoms
A patient with bipolar I disorder is most likely to experience which of the following during a
manic episode?
A. Hypersomnia
B. Anhedonia
C. Grandiosity
D. Social withdrawal
Correct Answer: C. Grandiosity
Rationale: Manic episodes are characterized by inflated self-esteem, decreased need for
sleep, and impulsive behavior.
Which brain structure is hyperactive in anxiety disorders, contributing to heightened fear
responses?
A. Hippocampus
B. Amygdala
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, C. Thalamus
D. Cerebellum
Correct Answer: B. Amygdala
Rationale: The amygdala is involved in processing fear and is often overactive in anxiety
disorders.
Which of the following is a negative symptom of schizophrenia?
A. Hallucinations
B. Delusions
C. Disorganized speech
D. Flat affect
Correct Answer: D. Flat affect
Rationale: Negative symptoms include diminished emotional expression, social withdrawal,
and lack of motivation.
What is the first-line treatment for generalized anxiety disorder (GAD)?
A. Benzodiazepines
B. SSRIs
C. Beta-blockers
D. Antipsychotics
Correct Answer: B. SSRIs
Rationale: SSRIs are the preferred first-line pharmacologic treatment for GAD due to their
efficacy and safety profile.
Which of the following is the main control center for hormonal regulation?
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