QUESTIONS AND ANSWERS VERIFIED
◉ NRDRI dosing. Answer: begin to work in 1-3 weeks and dosing
starts at 200mg. Max is 450mg
◉ SARIs. Answer: second-line antidepressant
anti-depressant induced insomnia
◉ SARI indications. Answer: depression
antidepressant induced insomnia
◉ SARI side effects. Answer: cardiac (orthostatic hypotension, QT
prolongation, arrhythmias)
sedation
nausea
elongated erections (priapism)
◉ SARI interactions. Answer: excessive sedation with other CNS
depressants
, decrease dosage of SARI when using ketoconazole/ritonavir
◉ SARI monitoring. Answer: BMP
◉ TCAs. Answer: second line for depression
imipramine
◉ TCA mechanism of action. Answer: block reuptake of serotonin
and norepinephrine, but also block histamine and acetylcholine
leading to side effects
◉ TCA indication. Answer: depression
enuresis (in children)
Off-Label
fibromyalgia
neuropathic pain
ADHD
panic disorder
OCD
insomnia