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What are the common causes of anemia? (Select all that apply.)
a. ) Impaired production
b. ) Blood transfusion
c. ) Increased red cell destruction
d. ) Severe bleeding
e. ) Chronic blood loss
a. ) Impaired production
c. ) Increased red cell destruction
d. ) Severe bleeding
e. ) Chronic blood loss
Impaired production of erythrocytes, blood loss (both acute or chronic), increased red cell
destruction, or any combination of these can cause anemia.
Which statement regarding fetal and adult hemoglobin is true?
a. ) Fetal hemoglobin is composed of two α- and two γ-chains.
b. ) Adult hemoglobin is composed of two α- and one γ-chain.
c. ) Adult hemoglobin is HbF and HbA.
d. ) Three of the embryonic hemoglobins are Gower 1, 2, and 3.
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,a. ) Fetal hemoglobin is composed of two α- and two γ-chains.
Fetal hemoglobin is HbF and is composed of two α- and two γ-chains. The adult hemoglobins
are HbA and HbA2 and are composed of two α- and two β-chains. The embryonic
hemoglobins are Gower 1, 2, and Portland.
Which statement regarding anemia is true in children?
a. ) Anemia is the most common cause is sickle cell disease.
b. ) Anemia is the most common blood disorder in children.
c. ) Lethargy and listlessness are common indicators of childhood anemia.
d. ) Iron deficiency anemia is rarely observed in young children.
b. ) Anemia is the most common blood disorder in children.
Of the options available, anemia is the most common blood disorder in children and the most
common cause is iron deficiency. The symptoms of mild anemia—lethargy and listlessness—
are usually not present or are inconsequential in infants and young children who are unable
to describe these symptoms.
Which statement is true regarding iron deficiency anemia?
a. ) Whites are more commonly affected.
b. ) Incidence of anemia is most common in children older than 2 years of age.
c. ) Children are at high risk because of their extremely high need of iron for normal growth.
d. ) Children of homeless women are at decreased risk.
c. ) Children are at high risk because of their extremely high need of iron for normal growth.
Iron deficiency anemia is common in children because of their extremely high need of iron for
normal growth. The incidence is not related to race but is related to socioeconomic factors
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,(i.e., increased prevalence in the children of single homeless women), which influence
nutrition. Iron deficiency anemia is most commonly found in children between the ages of 6
months and 2 years.
Which statement is true regarding iron deficiency?
a. ) Splenomegaly is present in 90% of those affected.
b. ) Pallor may accompany hemoglobin of less than 5 g/dL.
c. ) Tachycardia generally accompanies hemoglobin of 10 g/dL.
d. ) Widening of sutures is an early sign of iron deficiency.
b. ) Pallor may accompany hemoglobin of less than 5 g/dL.
Children with hemoglobin counts of less than 5 g/dL will demonstrate pallor, tachycardia, and
a systolic murmur. Splenomegaly is evident in 10% to 15% of children with iron deficiency
anemia. Mild-to-moderate iron deficiency (hemoglobin 6-10 g/dL) may show some cellular
changes. If the condition is long-standing, the sutures of the skull may widen.
Which statement is true regarding hemolytic disease of the fetus and newborn (HDFN)?
a. ) Fetal erythrocytes easily cross the placental barrier.
b. ) The first Rh-incompatible pregnancy usually has severe complications.
c. ) Anti-Rh antibodies are formed only in the response to transfusion.
d. ) ABO incompatibility HDFN is usually less severe than Rh incompatibility.
d. ) ABO incompatibility HDFN is usually less severe than Rh incompatibility.
The pathophysiologic effects of HDFN are more severe in Rh incompatibility than in ABO
incompatibility. The first Rh-incompatible pregnancy usually occurs with no difficulties. Anti-
Rh antibodies are formed in response to the presence of incompatible (Rh-positive)
erythrocytes in the blood of an Rh-negative mother for many reasons, not just transfusion.
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, Which is the appropriate term for an alloimmune disease in which maternal blood and fetal
blood are antigenically incompatible?
a. ) Hemolytic disease of the fetus and newborn
b. ) Hydrops fetalis
c. ) Icterus neonatorum
d. ) Icterus gravis neonatorum
a. ) Hemolytic disease of the fetus and newborn
Hemolytic disease of the fetus and newborn (HDFN) is an alloimmune disease in which
maternal blood and fetal blood are antigenically incompatible. Hydrops fetalis is the term for
fetuses that do not survive anemia in utero; they are stillborn with gross edema of the entire
body. Icterus neonatorum is neonatal jaundice. Cerebral damage from kernicterus causes
death (icterus gravis neonatorum).
Which statement is true regarding the Coombs test?
a. ) Indirect Coombs test confirms the diagnosis of antibody-mediated hemolytic disease.
b. ) Indirect Coombs test measures antibodies in the mother’s circulation.
c. ) Direct Coombs test indicates whether the fetus is at risk for hemolytic disease.
d. ) Direct Coombs test measures maternal antibody titers.
b. ) Indirect Coombs test measures antibodies in the mother's circulation.
The indirect Coombs test measures antibodies in the mother's circulation and indicates
whether the fetus is at risk for hemolytic disease. The direct Coombs test measures antibody
already bound to the surfaces of fetal erythrocytes and is primarily used to confirm the
diagnosis of antibody-mediated hemolytic disease.
Which statement is true regarding hereditary spherocytosis?
a. ) Hereditary spherocytosis is autosomal recessive trait.
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