and Correct Detailed Answers Already
Graded A+
Thalassemia Diagnostic Manifestations - CORRECT ANSWER-▪ Hemoglobin
electrophoresis = diagnostic test
▪ Low MCV, low MCH
▪ Ferritin normal to high
▪ Serum iron normal to high
▪ TIBC normal
Macrocytic-Normochromic Anemias - CORRECT ANSWER-"megaloblastic
anemias"
Large size, normal amount of Hgb
• Structurally abnormal = immature RBCs
• Leads to:
,- defective DNA synthesis
- Vitamin B12 or folate deficiencies
- premature release of RBCs
Types:
- Vitamin B12 Deficiency Anemia
- Pernicious Anemia
- Folate Deficiency Anemia
- Alcohol Induced
Vitamin B12 Deficiency - CORRECT ANSWER-Type of Macrocytic-
Normochromic Anemia
Source comes from diet (animal products ) -- commonly seen in strict vegans
▪ Liver stores up to 3 years' worth - unusual to develop deficiency due to diet
Importance of Vitamin B12 and Folate - CORRECT ANSWER-Vitamin B12:
▪ Keeps nervous system functioning properly
,▪ Necessary in the formation of blood
▪ Involved in metabolism of every cell but especially affecting DNA synthesis and
regulation
Folate:
▪ Essential for RNA and DNA synthesis
Vitamin B12 Deficiency Lab findings - CORRECT ANSWER-↑ MCV
↓Ferritin
↓serum iron
↑ TIBC
↑ MCH
↑RDW (>15)
↓reticulocyte count
** possible pancytopenia if severe **
Folate Deficiency Anemia - CORRECT ANSWER-Type of Macrocytic-
Normochromic Anemia
, Most common cause of deficiency: DIET - alcoholics, anorexics, overcooked food,
diets excluding veg
- Found in plant products and fortified foods; deficient in alcoholics and chronic
malnutrition; associated with neural tube defects in fetus
Folate Deficiency Anemia Manifestations - CORRECT ANSWER-- Severe
cheilosis (scales and fissures of lips and corners of mouth)
- Stomatitis
- Dysphagia
- Ulcerations of mouth and tongue
** No neuro symptoms **
Folate Deficiency Anemia Lab Findings - CORRECT ANSWER-- ↑MCV
- ↓ serum folic acid
- Normal MCH
Blood smear: hyper segmented neutrophils, anisocytosis, poikilocytosis;
megaloblastic RBCs