Normal Red Cell
Destruction
1
,Objectives
• Discuss the biochemistry of normal red cell destruction
•Understand the recycling of red cell constituents
•Name the different Types of Red Cell Destructions
•Describe different Mechanisms of red cell destruction
•Removal of old red cell by different organs (Spleen and other organs)
•The role of Macrophages in recognizing old cells
•Process of recycling of hemoglobin (Pathway for haem degradation)
•Formation of bilirubin in splenic macrophage
•Formation of conjugation of bilirubin and bilirubin
•Mechanism of Iron cycle and uptake
•Examples of Red Cell Destructions (Different types of Auto-immune hemolytic Anemia)
2
, Introduction
• RBCs are maintained in the normal
range by equilibrium processes of
production and destruction.
• Approximately 5 million RBC are
destroyed by macrophages every
second as 2 million enter the
circulation every second.
3
https://courses.lumenlearning.com/suny-ap2/chapter/erythrocytes/
Destruction
1
,Objectives
• Discuss the biochemistry of normal red cell destruction
•Understand the recycling of red cell constituents
•Name the different Types of Red Cell Destructions
•Describe different Mechanisms of red cell destruction
•Removal of old red cell by different organs (Spleen and other organs)
•The role of Macrophages in recognizing old cells
•Process of recycling of hemoglobin (Pathway for haem degradation)
•Formation of bilirubin in splenic macrophage
•Formation of conjugation of bilirubin and bilirubin
•Mechanism of Iron cycle and uptake
•Examples of Red Cell Destructions (Different types of Auto-immune hemolytic Anemia)
2
, Introduction
• RBCs are maintained in the normal
range by equilibrium processes of
production and destruction.
• Approximately 5 million RBC are
destroyed by macrophages every
second as 2 million enter the
circulation every second.
3
https://courses.lumenlearning.com/suny-ap2/chapter/erythrocytes/
