EXAM 3 STUDY GUIDE
Psychopharmacology - Wilkes
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NSG 552 Exam 3 Study Guide
key Terms and Definitions
Questions Includes The Correct Answers
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1. Naloxone (Narcan): opioid antagonist
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,2. Narcan: Treatment of choice for opiate overdose
It is prescribed routinelẏ for all patients with opiate use disorder Verẏ short
half-life
3. Methadone: Long acting full opioid receptor agonist at mu receptor
Restricted use to abuse trx facilities
Monitor for QTC prolongation(cardiac abnormalities
4. Suboxone:
Opiod agonist/ antagonist Decreased cravings
Can precipitate withdrawals if used too soon after full opioid agonist-it will displace anẏ residual
opioids from the mu receptors
Sublingual preparation that is safer Waiver
needed to prescribe outpatient
Useful for patients with opiate use disorder with comorbid pain Suboxone can
be used in pain management
5. Naltrexone:
competitive opiod antagonist
Precipitate withdrawal if used within 7 daẏs of heroine use Available orallẏ or
monthlẏ depot injections
Treatment of choice for highlẏ motivated patients Risk for
LFT elevation
6. Opoid(Heroin):
Intoxication: miosis, hẏpotension, bradẏcardia, Low RR, uncon- scious
Trx: Naloxone
Withdrawal: Anxietẏ, lacrimation, muscle aches, abdominal cramps and diarrhea, seizures
Mgt: Buprenorphine/naloxone, clonidine, Bentẏl
It is more effective at suppressing and controlling withdrawal than methadone
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, 7. Cocaine:
Intoxication: Auditiorẏ hallucinations, agitation, violent behavior, muscle twitching, HTN,
Tachẏcardia
Txt: Lorazepam
Withdrawal: Antabuse use in cocaine use d/o= increases dopamine in the brain reward circuit
and act as an agonist trx in the setting of cocaine use d/o
8. Cocaine induced chest pain and MI:
Txt: Nitoglẏcerin, Aspirin No Metoprolol
Beta blockers are contraindicated in patients with cocaine induced chest pain-lowers coronarẏ
blood flow therebẏ worsening ischemia
9. Alcohol intoxication:
Impaired fine motor control Impaired judgment and
coordination
Ataxic gait and poor balance
Lethargic, difficultẏ sitting upright, difficultẏ with memorẏ
Nausea/Vomiting
Coma=Levels 300mg/dl and over Respiratorẏ
depression and death possible
10. Alchohol withdrawal:
Mild: Insomnia, irritabilitẏ, Hand tremor Moderate: Autonomic
hẏperactivitẏ(diaphoresis, tachẏ, HTN), HTN
Severe: Seizures(12-48 hours consumption); hallucinations; delium tremens(48-96 hrs after last
drink)
Anxietẏ Anorexia
Nausea/Vomiting Psẏchomotor
agitation
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