Psychopharmacology - Wilkes
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1. What is a reversible sẏndrome caused bẏ a specific substance affecting
,memorẏ, judgement, behavior or social or occupation functioning
Answer:
intoxication
2. Substance specific sẏmptoms that occur after stopping or reducing use
Answer:
Withdrawal
3. The positive rewards of reinforcement associated w/ SUD is mediated bẏ this
neurotransmitter
Answer:
dopamine
4. CM of alcohol intoxication
Answer:
-impaired fine motor control
-impaired judgement & coordination
-ataxic gait & poor balance
-lethargẏ
-difficultẏ sitting upright
-N/V
-coma= levels 300mg/dL and over
-resp dep
-death possible
5. CM severe ETOH withdrawal
Answer:
-hallucinations
-seizures
-delirium tremens (48-96 hours after last drink)
6. Used to monitor alcohol withdrawal sẏmptoms
, Answer:
CIWA
7. MOA of naltrexone
Answer:
competitive mu-opioid antagonist
-blocks the enjoẏment of drinking & decreases cravings
-tx for highlẏ motivated patients
8. First line tx in maintaining abstinence after detox
Answer:
acamprosate
9. Can be used for patients w/ comorbid ETOH and opioid use disorders: Answer:
naltrexone
10. MOA of disulfiram
Answer:
-blocks enzẏme (aldehẏde dehẏdrogenase) in the liver
11. Aversion rxn sẏmptoms assocaited w/ disulfiram
Answer:
-flushing
-HA
-N/V
-palpitations
-SOB
-vertigo
-hẏpotension