I-HUMAN PATIENT CASE STUDY
Betty Burns — Part 1
Basic Differential Diagnosis | Complete Expert Walkthrough
48 y/o Female Breast Lump Invasive Ductal Ca. ER− PR− HER2 3+
Patient Age & Sex Chief Complaint Final Diagnosis Receptor Status
▌ Patient Profile ▌ What's Included
Patient Name: Betty Burns HISTORY
Age / Height / Weight: 48 yrs | 5'6" | 165 lbs ◆ All required history questions asked
Chief Complaint: Self-detected breast lump ◆ Correct phrasing & MSAP-related answers
MSAP Finding: Painless, 2cm left breast mass — firm, fixed ◆ Risk factor exploration (BRCA, HRT, menarche)
Axillary Node: 1 cm fixed left axilla LN PHYSICAL EXAM
Histopathology: Invasive Ductal Carcinoma ◆ All key findings documented (correct + missing)
Receptor Status: ER neg / PR neg / HER2 3+ ◆ Breast, axilla, skin & lymph node exam
Family Hx: First-degree breast cancer (mother) ◆ MSAP findings with clinical significance
Menstrual Hx: Early menarche / late first pregnancy ASSESSMENT & DDX
◆ Key findings organized & ranked
▌ Differential Diagnoses
◆ Problem statement with Expert feedback
#1 LEAD Breast Mass/Lump, Neoplastic
◆ Full 5-item DDx with rationale
#2 Fibroadenoma
◆ Lead / Alternative / Must-Not-Miss tags
#3 Fibrocystic Disease (Breast Cysts)
TESTS & IMAGING
#4 Breast Lipoma
◆ Mammography — BI-RADS 5 Left Breast
#5 MNM Breast Hamartoma
◆ Breast Ultrasound — 3cm irregular solid mass
▌ Grading Breakdown ◆ Core Needle Biopsy — Invasive Ductal Ca.
✔ History Questions 30% ◆ Receptor analysis: HER2 3+
✔ Physical Examination 30% DIAGNOSIS & PLAN
✔ Differential Dx List 15%
◆ Final diagnosis confirmed with expert notes
✔ DDx Ranking (Lead/Alt/MNM) 10%
◆ SOAP note / assessment-management plan
✔ Lab / Imaging Tests 15%
◆ Surgical referral + staging plan
◆ Chemotherapy / radiation / hormone therapy
⚠ Clinical Pearl
A firm, fixed, painless breast mass with axillary lymphadenopathy,
family history of breast cancer, and BI-RADS 5 mammogram is
breast cancer until proven otherwise. Biopsy is mandatory.
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Betty Burns | i-Human | Part 1 | Basic DDx | Breast Lump | Breast Cancer | Self-Detected Mass | Differential Diagnosis | Fibroadenoma | Fibrocystic Disease |
Invasive Ductal Carcinoma | BI-RADS 5 | Mammography | Breast Ultrasound | Core Needle Biopsy | HER2 Positive | SOAP Note | NP Case Study | Nurse
Practitioner | APRN | FNP | DNP | Clinical Reasoning | Assessment Walkthrough | i-Human Patients | Physical Exam | History Taking | Must Not Miss | Lead
,Diagnosis | Key Findings | MSAP | Axillary Lymph Node | Breast Cancer Risk Factors | BRCA | Hormone Receptor | Surgical Referral | Chemotherapy | Radiation
Therapy
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