PHARMACOLOOGY, TOXICOLOGY, g g
PHARMACOKINETICS
PHARMACOLOGY,gTOXICOLOGY,gPHARMACOKINETICSg
1. Twogdose-
responsegcurvegresponsegplottedgongthegsameggraphgshowedgsigmoidgcurvesghavinggthegsamegslopegandgh
eight.gTgcurvegisglocatedgtogthegrightgofgthegAgcurve.gWhichgofgthegfollowinggstatementsgis/aregcorrectgre
gardinggcurvesgAgan:g
g
g
g
g
g
g
g
I. AgisgmoregeffectivegthangBg
II. AgisgmoregpotentgthangBg
III. AgandgBghavegthegsamegceilinggdoseg
IV. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgcompetitivegantagonistg
V. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgnon-competitivegantagonistg
g
a. OnlygIgandgIIIgaregcorrectg
b. OnlygII,gIIIgandgIVgaregcorrectg
c. OnlygIIgandgIVgaregcorrectg
d. OnlygIIIgandgVgaregcorrectg
e. OnlygVgisgcorrectg
, 2. Twogdose-
responsegcurvegplottedgongthegsameggraphgshowedgsigmoidgcurvesgAgandgB,gwheregAgisgatgthegleftgofgth
eggraphgwithgthegheightggreatergthangB.gWhichgofgthegfollowinggstatementsgis/aregcorrectgregardinggcurve
sgAgandgB?g
g
g
g
g
g
g
g
I. AgandgBghasgequalgefficacyg
II. AgandgBghavegequalgpotencyg
III. BgisgagpartialgagonistgofgAg
IV. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgcompetitivegantagonistg
V. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgnon-competitivegantagonistg
g
a. OnlygIgandgIIIgaregcorrectg
b. OnlygII,gIIIgandgIVgaregcorrectg
c. OnlygIIgandgIVgaregcorrectg
d. OnlygIIIgandgVgaregcorrectg
e. OnlygVgisgcorrectg
, 3. Thegcumulativegnumbergofgsubjectsgwhogdisplaygagcertaingrersponsegorgeffectgtogagdruggisgplottedgongagg
raphgasgshowngbelow.gTheggraphgongthegleftgrepresentsgbeneficialgeffectgwhilegtheggraphgongthegrightgrep
resentsgtoxicgeffect,gwhatgisgthegtherapeuticgindexgofgthegdrug?g
g
g
g
g
g
g
a.0.5ggggggggggggggggggggggggggb.g1.5gggggggggggggggggggggggggggggc.g2.5ggggggggggggggggggggggggggggggd.4.0ggg
ggggggggggggggggggggggggggge.g5.0g
4. Angadministrationgofgonegdruggleadsgtogagshiftgingthegloggdose-
responsegcurvegofganothergdruggtogthegleftgagrangegingthegmaximalgefficacy,gthisgisgcalledg
a.gAgonismg
b. Partialgagonismg
c. Non-competitivegantagonismg
d. Competitivegantagonismg
e. Potentiationg
5. Thegactiongofgthisgdruggisgdependentgongagcolligativegpropertyg
a. Mannitolg
b. Cocaineg
c. Reserpineg
d. Furosemideg
e. Losartang
6. Whiichgofgthegfollowinggdrugggroupsghavegmechanismsgofgaactiongthatginvolvegbindinggtogenzymesgasgta
rgetgprotiensg
a.gBenzodiazepinesg 3
b.gIgand 6
c.gIIIgonlygd.gIgand 6
e.gI,gII,gand 6
b. Barbituratesg
c. Calciumgchannelgblockersg
d. Non-steroidalganti-inflammatorygagentsg
e. Phenothiazinegantipsychoticsg
, 7. Voltage-gatedgiongchannelsgservegasgsitegofgactionsgforgdrugsgsuchgasg
I. DiltiazemgandgNifedipineg
II. LidocainegandgProcaineg
III. CaptoprilgandgLosartang
a.gIgonlyg
8. DrugsgwithgmechanismgofgactiongthatginvolvesgTubulin-
bindinggleadinggtoglossgofgfunctiongofgthegstructuralgprotiengincludeg
a. Cyclosporineg
b. Neostigmineg
c. Colchicineg
d. Glibenclamideg
e. Metforming
9. WhatgtypegofgprotiengisgprimarilygtargetedgbygDigitalisgglycosidesgwhengtheygexertgtheirgeffectgongtheghe
art?ga.gReceptorsg
b. Iongchannelsg
c. Enzymesg
d. Transportersg
e. Structuralgprotiensg
10. Whichgofgthegfollowinggfeaturesgcahracterizegnicotinic,gGABA-A,gandgGlutamategreceptors?g
a. Thaygcontrolgthegmovementsgofgionsgandgoutgofgthegcellg
b. Theirgactiongisgmediatedgbysecondarygmessengersg
c. Theygallghavegexcitatorygeffectgongthegcellgmembraneg
d. Theygareglocatedgongthegcytoplasmg
11. Whichgofgthegfollowinggdrugsgbindgtogreceptorsglocatedgatgthegcellgmembrane?g
a. Thyroidghormoneg
b. Prednisoneg
c. Estrogeng
d. Insuling
e. VitamingDg
12. CyclicgAdenosinegMonophophateg(cAMP)gisggeneratedgasgagsecondarygmessengergbygthegactiongofgthege
nzymegAdenylylgCyclase.gThegsubstrategforgthegsynthesisgofgcAMPgisg
a. AMDg
b. ADPg
c. ATPg
d. GTPg
e. Adenosinegg
13. StimulationgofgBeta-adrenoceptor,gagG-protien-
linkedgreceptorginvolvesgaggenerationgofgagsecondarygmessengergknowngasgg
a. IP3g
b. cGTPg
c. DAGg
d. cAMPg
e. Calciumgionsg
14. WhatgisgthegmechanismgofgactiongofgSildenafil,gagdruggpopularlygknowngasgviagra?g
a. Inhibitsgphosphodiesteraseg(PDE)gleadinggtogincreasegcAMPg
b. InhibitsgPDEgleadinggtogincreasegcGMPg
c. StimulatesgadenylylgcyclasegleadinggtogincreasegcAMPg
d. StimulatesgguanylylgcyclasegleadinggtogincreasegcGMPg
e. InhibitsgphosphodiesterasegleadinggtogincreasegcGMPg
15. DrugsgthatgactivategthegphospholipasegC-inositolgphosphategsystemgsuchgasgalpha-
adrenergicgagonistsglikegphenylephrinegprimarilygcausegangincreasegingthegintracellularglevelsgofgwhichgio
n?g
a. Calciumg
PHARMACOKINETICS
PHARMACOLOGY,gTOXICOLOGY,gPHARMACOKINETICSg
1. Twogdose-
responsegcurvegresponsegplottedgongthegsameggraphgshowedgsigmoidgcurvesghavinggthegsamegslopegandgh
eight.gTgcurvegisglocatedgtogthegrightgofgthegAgcurve.gWhichgofgthegfollowinggstatementsgis/aregcorrectgre
gardinggcurvesgAgan:g
g
g
g
g
g
g
g
I. AgisgmoregeffectivegthangBg
II. AgisgmoregpotentgthangBg
III. AgandgBghavegthegsamegceilinggdoseg
IV. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgcompetitivegantagonistg
V. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgnon-competitivegantagonistg
g
a. OnlygIgandgIIIgaregcorrectg
b. OnlygII,gIIIgandgIVgaregcorrectg
c. OnlygIIgandgIVgaregcorrectg
d. OnlygIIIgandgVgaregcorrectg
e. OnlygVgisgcorrectg
, 2. Twogdose-
responsegcurvegplottedgongthegsameggraphgshowedgsigmoidgcurvesgAgandgB,gwheregAgisgatgthegleftgofgth
eggraphgwithgthegheightggreatergthangB.gWhichgofgthegfollowinggstatementsgis/aregcorrectgregardinggcurve
sgAgandgB?g
g
g
g
g
g
g
g
I. AgandgBghasgequalgefficacyg
II. AgandgBghavegequalgpotencyg
III. BgisgagpartialgagonistgofgAg
IV. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgcompetitivegantagonistg
V. BgisgtheggraphgproducedgwhengAgisggivengwithgitsgnon-competitivegantagonistg
g
a. OnlygIgandgIIIgaregcorrectg
b. OnlygII,gIIIgandgIVgaregcorrectg
c. OnlygIIgandgIVgaregcorrectg
d. OnlygIIIgandgVgaregcorrectg
e. OnlygVgisgcorrectg
, 3. Thegcumulativegnumbergofgsubjectsgwhogdisplaygagcertaingrersponsegorgeffectgtogagdruggisgplottedgongagg
raphgasgshowngbelow.gTheggraphgongthegleftgrepresentsgbeneficialgeffectgwhilegtheggraphgongthegrightgrep
resentsgtoxicgeffect,gwhatgisgthegtherapeuticgindexgofgthegdrug?g
g
g
g
g
g
g
a.0.5ggggggggggggggggggggggggggb.g1.5gggggggggggggggggggggggggggggc.g2.5ggggggggggggggggggggggggggggggd.4.0ggg
ggggggggggggggggggggggggggge.g5.0g
4. Angadministrationgofgonegdruggleadsgtogagshiftgingthegloggdose-
responsegcurvegofganothergdruggtogthegleftgagrangegingthegmaximalgefficacy,gthisgisgcalledg
a.gAgonismg
b. Partialgagonismg
c. Non-competitivegantagonismg
d. Competitivegantagonismg
e. Potentiationg
5. Thegactiongofgthisgdruggisgdependentgongagcolligativegpropertyg
a. Mannitolg
b. Cocaineg
c. Reserpineg
d. Furosemideg
e. Losartang
6. Whiichgofgthegfollowinggdrugggroupsghavegmechanismsgofgaactiongthatginvolvegbindinggtogenzymesgasgta
rgetgprotiensg
a.gBenzodiazepinesg 3
b.gIgand 6
c.gIIIgonlygd.gIgand 6
e.gI,gII,gand 6
b. Barbituratesg
c. Calciumgchannelgblockersg
d. Non-steroidalganti-inflammatorygagentsg
e. Phenothiazinegantipsychoticsg
, 7. Voltage-gatedgiongchannelsgservegasgsitegofgactionsgforgdrugsgsuchgasg
I. DiltiazemgandgNifedipineg
II. LidocainegandgProcaineg
III. CaptoprilgandgLosartang
a.gIgonlyg
8. DrugsgwithgmechanismgofgactiongthatginvolvesgTubulin-
bindinggleadinggtoglossgofgfunctiongofgthegstructuralgprotiengincludeg
a. Cyclosporineg
b. Neostigmineg
c. Colchicineg
d. Glibenclamideg
e. Metforming
9. WhatgtypegofgprotiengisgprimarilygtargetedgbygDigitalisgglycosidesgwhengtheygexertgtheirgeffectgongtheghe
art?ga.gReceptorsg
b. Iongchannelsg
c. Enzymesg
d. Transportersg
e. Structuralgprotiensg
10. Whichgofgthegfollowinggfeaturesgcahracterizegnicotinic,gGABA-A,gandgGlutamategreceptors?g
a. Thaygcontrolgthegmovementsgofgionsgandgoutgofgthegcellg
b. Theirgactiongisgmediatedgbysecondarygmessengersg
c. Theygallghavegexcitatorygeffectgongthegcellgmembraneg
d. Theygareglocatedgongthegcytoplasmg
11. Whichgofgthegfollowinggdrugsgbindgtogreceptorsglocatedgatgthegcellgmembrane?g
a. Thyroidghormoneg
b. Prednisoneg
c. Estrogeng
d. Insuling
e. VitamingDg
12. CyclicgAdenosinegMonophophateg(cAMP)gisggeneratedgasgagsecondarygmessengergbygthegactiongofgthege
nzymegAdenylylgCyclase.gThegsubstrategforgthegsynthesisgofgcAMPgisg
a. AMDg
b. ADPg
c. ATPg
d. GTPg
e. Adenosinegg
13. StimulationgofgBeta-adrenoceptor,gagG-protien-
linkedgreceptorginvolvesgaggenerationgofgagsecondarygmessengergknowngasgg
a. IP3g
b. cGTPg
c. DAGg
d. cAMPg
e. Calciumgionsg
14. WhatgisgthegmechanismgofgactiongofgSildenafil,gagdruggpopularlygknowngasgviagra?g
a. Inhibitsgphosphodiesteraseg(PDE)gleadinggtogincreasegcAMPg
b. InhibitsgPDEgleadinggtogincreasegcGMPg
c. StimulatesgadenylylgcyclasegleadinggtogincreasegcAMPg
d. StimulatesgguanylylgcyclasegleadinggtogincreasegcGMPg
e. InhibitsgphosphodiesterasegleadinggtogincreasegcGMPg
15. DrugsgthatgactivategthegphospholipasegC-inositolgphosphategsystemgsuchgasgalpha-
adrenergicgagonistsglikegphenylephrinegprimarilygcausegangincreasegingthegintracellularglevelsgofgwhichgio
n?g
a. Calciumg
