INTEGRATIVE APPROACH WITH EXPANDED
TOPICS 1ST EDITION TANSEY, 2026) 25
CHAPTERS UPDATED
,TABLE OF CONTENT
1. Chapter 1 The Chemical Foundations of Biochemistry
2. Chapter 2 Nucleic Acids
3. Chapter 3 Proteins I
4. Chapter 4 Proteins II—Enzymes
5. Chapter 5 Membranes and an Introduction to Signal Transduction
6. Chapter 6 Carbohydrates I
7. Chapter 7 The Common Catabolic Pathway
8. Chapter 8 Carbohydrates II
9. Chapter 9 Lipids I
10.Chapter 10 Lipids II
11.Chapter 11 Amine Metabolism
12.Chapter 12 Metabolism Integration
13.Chapter 13 Nucleotide & Deoxynucleotide Metabolism
14.Chapter 14 DNA Replication, Damage and Repair
15.Chapter 15 RNA Synthesis And Processing
16.Chapter 16 Protein Synthesis
17.Chapter 17 Control Of Gene Expression
18.Chapter 18 Determination of Macromolecular Structure
19.Chapter 19 Allosterism and Receptor-Ligand Interactions
20.Chapter 20 Designer Proteins and Protein Folding
21.Chapter 21 Biomolecule Purification
22.Chapter 22 Bioinformatics and Omics
23.Chapter 23 Signal Transduction
24.Chapter 24 Protein Trafficking
25.Chapter 25 Photosynthesis & Nitrogen Fixation
,CHAPTER 1: THE CHEMICAL FOUNDATIONS OF BIOCHEMISTRY
This chapter explores the fundamental chemical principles underlying
biochemistry, including atomic structure, chemical bonds, thermodynamics, and
molecular interactions. Emphasis is placed on the properties of water, pH and
buffering systems, and the behavior of ions and small molecules. Nurses must
understand these principles to interpret lab results, manage electrolytes, and
apply biochemical knowledge to clinical decision-making.
1. Which subatomic particle has a positive charge?
A. Electron
B. Neutron
C. Proton
D. Positron
- CORRECT ANSWER - : C
Rationale: Protons carry a positive charge; electrons are negative and
neutrons are neutral. Positrons are antimatter counterparts of electrons.
2. Water’s ability to form hydrogen bonds primarily contributes to which
property?
A. High viscosity
B. High heat capacity
C. Low polarity
D. Lack of cohesion
- CORRECT ANSWER - : B
Rationale: Hydrogen bonding in water allows it to absorb and retain heat,
contributing to thermal stability essential for biochemical reactions.
3. Which bond is strongest in stabilizing protein tertiary structure?
A. Hydrogen bond
B. Ionic bond
, C. Covalent bond
D. Van der Waals interactions
- CORRECT ANSWER - : C
Rationale: Covalent bonds, including disulfide bridges, are stronger than
noncovalent interactions and provide significant structural stability.
4. pH measures:
A. Hydrogen ion concentration
B. Hydroxide ion concentration
C. Sodium ion concentration
D. Proton acceptor concentration
- CORRECT ANSWER - : A
Rationale: pH quantifies the hydrogen ion (H⁺) concentration, directly
influencing enzymatic activity and cellular function.
5. Which molecule acts as a universal solvent in biological systems?
A. Ethanol
B. Water
C. Methane
D. Chloroform
- CORRECT ANSWER - : B
Rationale: Water’s polarity and hydrogen bonding allow it to dissolve a
wide range of solutes, critical for biochemical reactions.
6. An ionic bond forms due to:
A. Sharing of electrons
B. Transfer of electrons
C. Hydrogen sharing
D. van der Waals forces
- CORRECT ANSWER - : B