Science Exam Guide: Autism, Rett Syndrome,
ADHD, Conduct and Oppositional Disorders,
Mood Disorders, Bipolar Types, Personality
Disorders, Psychosis, Schizophrenia, Anxiety
Disorders, Substance Use, Withdrawal
Syndromes, Delirium, Dementia,
Neurocognitive Disorders, Psychodynamic
Mechanisms, Defense Mechanisms,
Pharmacology of Antidepressants,
Antipsychotics, Mood Stabilizers, and High-
Yield Clinical Correlations for Step 2 and
USMLE Exams Questions Provided with A+
Graded Rationales Latest Updated 2026
what is autism?
Poor eye contact,
repetitive movements,
lack of verbal skills and bonding,
symptoms since birth
What is Rett's? [Mutations MECP2 on X Chromosome]
only in girls, decreased head growth, lose motor skills, hand wringing, they are normal until 5
months of age.
what is the treatment for autism?
behavioral modification,
use antipsychotic if have aggressive behavior
what is the treatment for Rett's?
behavioral therapy and physiotherapy
What is childhood disintegrative disorder?
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,Kid stops walking/talking (they lose all their milestones)
what is selective mutism?
Kid talks only to certain people
what is separation anxiety disorder?
Factitious complaints to miss school. Fear of separation from home or attachment for >/< 4
weeks. Normal ages 3-4 y/o
what is conduct disorder?
Younger than 18yo
with traits of antisocial disorder, aggressive,
disregard for authority/rules,
no sense of guilt/remorse, harms animals,
illegal activity
"bite is worse than bark"
behavioral therapy and antipsychotic -if aggressive
what is the treatment for conduct disorder?
behavioral therapy and antipsychotic if aggressive
What is oppositional defiant disorder?
Breaking the rules, defiant, noncompliant, resists authority figures (teachers, parents) fine with
peers and siblings. Teach appropriate child management skills.
"bark is worse than bite"
Teach appropriate child management skills
what is the treatment for oppositional defiant disorder?
teach appropriate child management skills
What is Attention Deficit Hyperactivity Disorder?
Over activity,
short attention span,
difficulty in school,
must be identified in two different locations-home and school
what is the treatment for Attention Deficit Hyperactivity Disorder?
First line:
-Methylphenidate [Ritalin] and Dextroamphetamine [Dexedrine, Dextrostat];
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, second line-:
-Atomoxetine [Strattera]-SNRI
how is major depression diagnosed?
need 5 "SIGE CAPS" >2wks
• Sleep disturbances - wake in the early AM or waking up late
• Interest/Libido loss
• Guilt
• Energy loss
• Concentration loss
• Appetite loss
• Psychomotor agitation
• Suicidal ideation (hopelessness)
what is dysthymia?
Low level sadness >2 years,
looks like depression.
Tx: psychotherapy and SSRI
What is cyclothymia?
Dysthymia (long depression) with hypomania for more than 2 years.
Tx: Lithium, Valproic acid
or Carbamazepine and psychotherapy
what is the treatment for dysthymia?
psychotherapy and SSRI
what is the treatment for cyclothymia?
Lithium, valproic acid or carbamazepine
and psychotherapy
what is double depression?
Depression followed by dysthymia
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