Ultimate High-Yield Dermatology,
Autoimmune, Infectious, and Systemic
Disease Exam Guide: Primary Biliary
Cirrhosis, Sclerosing Cholangitis,
Autoimmune Hepatitis, Bullous Disorders,
Celiac Disease, Connective Tissue Diseases,
Lupus, Vasculitis, Skin Infections, Fungal and
Viral Dermatoses, Drug Reactions, Pediatric
Exanthems, Tick-Borne Illnesses, Bite and
Sting Reactions, Pharmacologic Treatments,
Immunologic Markers, and Complete High-
Yield Clinical Correlations for USMLE Step 2
and Shelf Exams Questions Provided with A+
Graded Rationales Latest Updated 2026
what is primary biliary cirrhosis?
seen in females, pruritus, xanthomas, anti-mitochondrial antibody
what is primary sclerosing cholangitis?
p-ANCA antibody, bile duct inflammation, onion skinning, IBD
Intra and extra hepatic ducts involved
what is type 1 autoimmune hepaptitis?
seen in young women, anti-smooth muscle Ab
what is type 2 autoimmune hepatitis?
seen in kids, anti-LKM Ab
what is bullous pemphigoid?
anti-hemidesmosome antibody, sub epithelial skin bullae
what is celiac sprue?
1|Page
,anti-gliaden antibody, can't eat wheat/ bread products = steatorrhea, associated with dermatitis
herpetiformis
what antibody is associated with CREST syndrome?
Anti-centromere
what is dermatitis herpetiformis?
Vesicles on anterior thigh, Anti-BMZ Ab, Anti-Endomysial Ab
what is dermatomyositis?
anti-jo-1 myositis with a rash, associated with occult malignancy
what is DM type 1?
polyuria
polydipsia
wt loss
anti-islet cell Ab
Anti-GAD Ab
post infection
DKA
What is drug induced lupus?
Anti-histone Ab, "HIPPPE" drugs cause it:
H- Hydralazine
I- INH
P-Phenytoin
P- Procainamide
P- Penicillamine
E- Ethosuximide
What is gastritis type A?
anti-parietal cell
an atrophic gastritis
adenocarcinoma
what is goodpastures?
Anti-GBM Ab, attacks lung and kidney, can progress to RPGN and death
What is Grave's disease?
2|Page
, Anti-TSHr Ab, hyperthyroid, exopthalmos, pretibial myxedema
What is ITP (immune thrombocytopenic purpura)?
Anti-platelet Ab, Anti-GP2b3a Ab, thrombocytopenia
what is mixed connective tissue disease (MCTD)?
anti-RNP Antibody
What is mononucleosis?
Heterophile antibody positive; teenager with sore throat, lymphadenopathy, splenomegaly,
kissing disease
what is MPGN type 2?
anti-C3 canvertase Ab = C3 nephritic factor
what is paroxysmal hemolysis?
Donath Landsteiner Ab, bleeds when they are cold
what is pemphigus vulgaris?
Anti-desmosome Ab, skin sloughs off when touched, starts in oral mucosa
what is pernicious anemia?
Anti-IF Ab, Vit B12 def => megaloblastic anemia
what is polyarteritis nodosa (inflammation of medium blood vessels? What Hypersensitivity?
p-ANCA Ab, attacks the gut kidneys and nervous system, associated with Hep B
infection, hypertension, skin findings, there is no pulmonary environment Type III
Hypersensitivity
What is Post-Strep GN?
ASO Ab, nephritic w/ complement deposition, after 3 weeks post infection
What is rheumatoid arthritis?
rheumatoid factor present
pain and swelling is worse in the morning,
anti-citrullinated peptide protein antibodies
What is scleroderma?
3|Page
Autoimmune, Infectious, and Systemic
Disease Exam Guide: Primary Biliary
Cirrhosis, Sclerosing Cholangitis,
Autoimmune Hepatitis, Bullous Disorders,
Celiac Disease, Connective Tissue Diseases,
Lupus, Vasculitis, Skin Infections, Fungal and
Viral Dermatoses, Drug Reactions, Pediatric
Exanthems, Tick-Borne Illnesses, Bite and
Sting Reactions, Pharmacologic Treatments,
Immunologic Markers, and Complete High-
Yield Clinical Correlations for USMLE Step 2
and Shelf Exams Questions Provided with A+
Graded Rationales Latest Updated 2026
what is primary biliary cirrhosis?
seen in females, pruritus, xanthomas, anti-mitochondrial antibody
what is primary sclerosing cholangitis?
p-ANCA antibody, bile duct inflammation, onion skinning, IBD
Intra and extra hepatic ducts involved
what is type 1 autoimmune hepaptitis?
seen in young women, anti-smooth muscle Ab
what is type 2 autoimmune hepatitis?
seen in kids, anti-LKM Ab
what is bullous pemphigoid?
anti-hemidesmosome antibody, sub epithelial skin bullae
what is celiac sprue?
1|Page
,anti-gliaden antibody, can't eat wheat/ bread products = steatorrhea, associated with dermatitis
herpetiformis
what antibody is associated with CREST syndrome?
Anti-centromere
what is dermatitis herpetiformis?
Vesicles on anterior thigh, Anti-BMZ Ab, Anti-Endomysial Ab
what is dermatomyositis?
anti-jo-1 myositis with a rash, associated with occult malignancy
what is DM type 1?
polyuria
polydipsia
wt loss
anti-islet cell Ab
Anti-GAD Ab
post infection
DKA
What is drug induced lupus?
Anti-histone Ab, "HIPPPE" drugs cause it:
H- Hydralazine
I- INH
P-Phenytoin
P- Procainamide
P- Penicillamine
E- Ethosuximide
What is gastritis type A?
anti-parietal cell
an atrophic gastritis
adenocarcinoma
what is goodpastures?
Anti-GBM Ab, attacks lung and kidney, can progress to RPGN and death
What is Grave's disease?
2|Page
, Anti-TSHr Ab, hyperthyroid, exopthalmos, pretibial myxedema
What is ITP (immune thrombocytopenic purpura)?
Anti-platelet Ab, Anti-GP2b3a Ab, thrombocytopenia
what is mixed connective tissue disease (MCTD)?
anti-RNP Antibody
What is mononucleosis?
Heterophile antibody positive; teenager with sore throat, lymphadenopathy, splenomegaly,
kissing disease
what is MPGN type 2?
anti-C3 canvertase Ab = C3 nephritic factor
what is paroxysmal hemolysis?
Donath Landsteiner Ab, bleeds when they are cold
what is pemphigus vulgaris?
Anti-desmosome Ab, skin sloughs off when touched, starts in oral mucosa
what is pernicious anemia?
Anti-IF Ab, Vit B12 def => megaloblastic anemia
what is polyarteritis nodosa (inflammation of medium blood vessels? What Hypersensitivity?
p-ANCA Ab, attacks the gut kidneys and nervous system, associated with Hep B
infection, hypertension, skin findings, there is no pulmonary environment Type III
Hypersensitivity
What is Post-Strep GN?
ASO Ab, nephritic w/ complement deposition, after 3 weeks post infection
What is rheumatoid arthritis?
rheumatoid factor present
pain and swelling is worse in the morning,
anti-citrullinated peptide protein antibodies
What is scleroderma?
3|Page
